The Experts below are selected from a list of 5748 Experts worldwide ranked by ideXlab platform
Maireanne Gougerotpocidalo - One of the best experts on this subject based on the ideXlab platform.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
Pham Mychan Dang - One of the best experts on this subject based on the ideXlab platform.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
Jamel Elbenna - One of the best experts on this subject based on the ideXlab platform.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
Carolina Jancic - One of the best experts on this subject based on the ideXlab platform.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
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rab27a regulates phagosomal ph and nadph oxidase recruitment to dendritic cell phagosomes
Nature Cell Biology, 2007Co-Authors: Carolina Jancic, Steve Pascolo, Ariel Savina, Tanya Tolmachova, Pham Mychan Dang, Jamel Elbenna, Christina Wasmeier, Maireanne GougerotpocidaloAbstract:To prevent excessive degradation of internalized antigens, which could destroy the peptides recognized by T lymphocytes, dendritic cells have developed several strategies that limit proteolytic activity in phagosomes. The recruitment of the NADPH oxidase NOX2 prevents acidification of phagosomes, limiting antigen degradation. Here, we show that dendritic cells derived from Rab27a-deficient ashen mice show increased phagosome acidification and antigen degradation, causing a defect in antigen cross-presentation. Enhanced acidification results from a delay in the recruitment to phagosomes of a subset of lysosome-related organelles containing the membrane subunits of NOX2. The Rab27a-dependent recruitment of these “inhibitory lysosome-related organelles” to phagosomes continuously limits acidification and degradation of ingested particles in dendritic cells, thus promoting antigen cross-presentation.
Shuli Niu - One of the best experts on this subject based on the ideXlab platform.
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Global soil acidification impacts on belowground processes
Environmental Research Letters, 2019Co-Authors: Cheng Meng, Dashuan Tian, Hui Zeng, Shuli NiuAbstract:With continuous nitrogen (N) enrichment and sulfur (S) deposition, soil acidification has accelerated and become a global environmental issue. However, a full understanding of the general pattern of ecosystem belowground processes in response to soil acidification due to the impacting factors remains elusive. We conducted a meta-analysis of soil acidification impacts on belowground functions using 304 observations from 49 independent studies, mainly including soil cations, soil nutrient, respiration, root and microbial biomass. Our results show that acid addition significantly reduced soil pH by 0.24 on average, with less pH decrease in forest than non-forest ecosystems. The response ratio of soil pH was positively correlated with site precipitation and temperature, but negatively with initial soil pH. Soil base cations (Ca2+, Mg2+, Na+) decreased while non-base cations (Al3+, Fe3+) increased with soil acidification. Soil respiration, fine root biomass, microbial biomass carbon and nitrogen were significantly reduced by 14.7%, 19.1%, 9.6% and 12.1%, respectively, under acid addition. These indicate that soil carbon processes are sensitive to soil acidification. Overall, our meta-analysis suggests a strong negative impact of soil acidification on belowground functions, with the potential to suppress soil carbon emission. It also arouses our attention to the toxic effects of soil ions on terrestrial ecosystems.
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a global analysis of soil acidification caused by nitrogen addition
Environmental Research Letters, 2015Co-Authors: Dashuan Tian, Shuli NiuAbstract:Nitrogen (N) deposition-induced soil acidification has become a global problem. However, the response patterns of soil acidification to N addition and the underlying mechanisms remain far from clear. Here, we conducted a meta-analysis of 106 studies to reveal global patterns of soil acidification in responses to N addition. We found that N addition significantly reduced soil pH by 0.26 on average globally. However, the responses of soil pH varied with ecosystem types, N addition rate, N fertilization forms, and experimental durations. Soil pH decreased most in grassland, whereas boreal forest was not observed a decrease to N addition in soil acidification. Soil pH decreased linearly with N addition rates. Addition of urea and NH4NO3 contributed more to soil acidification than NH4-form fertilizer. When experimental duration was longer than 20 years, N addition effects on soil acidification diminished. Environmental factors such as initial soil pH, soil carbon and nitrogen content, precipitation, and temperature all influenced the responses of soil pH. Base cations of Ca2+, Mg2+ and K+ were critical important in buffering against N-induced soil acidification at the early stage. However, N addition has shifted global soils into the Al3+ buffering phase. Overall, this study indicates that acidification in global soils is very sensitive to N deposition, which is greatly modified by biotic and abiotic factors. Global soils are now at a buffering transition from base cations (Ca2+, Mg2+ and K+) to non-base cations (Mn2+ and Al3+). This calls our attention to care about the limitation of base cations and the toxic impact of non-base cations for terrestrial ecosystems with N deposition.