The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform
Angel De Lera - One of the best experts on this subject based on the ideXlab platform.
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Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem, 2009Co-Authors: Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Angel De LeraAbstract:A collection of Arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran Arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
Efrén Pérez Santín - One of the best experts on this subject based on the ideXlab platform.
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Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem, 2009Co-Authors: Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Angel De LeraAbstract:A collection of Arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran Arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
Pascale Mauvais - One of the best experts on this subject based on the ideXlab platform.
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Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem, 2009Co-Authors: Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Angel De LeraAbstract:A collection of Arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran Arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
Pascal Collette - One of the best experts on this subject based on the ideXlab platform.
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Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem, 2009Co-Authors: Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Angel De LeraAbstract:A collection of Arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran Arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.
Johannes Voegel - One of the best experts on this subject based on the ideXlab platform.
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Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem, 2009Co-Authors: Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Angel De LeraAbstract:A collection of Arotinoids with a central benzofuran or naphthofuran ring structure was efficiently synthesized by a three-step process that comprises a Sonogashira coupling, an iodine-induced 5-endo-dig cyclization of the o-methoxyphenyl- or naphthyl-ethynyl benzoates, and finally a Suzuki/Sonogashira coupling of the corresponding 3-iodobenzo- or naphthofurans. Most of these 3-substituted naphthofuran Arotinoids (but not the 5,7-di-tert-butylbenzofurans with the same substitution pattern at the C2 and C3 positions) are potent agonists of the retinoic acid receptor (RAR) subtypes, with activities in the nanomolar range.