The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Hui Zhang - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of sulfonyl substituted trans 2 3 dihydrofuran derivatives via reaction of Arsonium ylides with α β unsaturated ketones
Chemical Research in Chinese Universities, 2014Co-Authors: Xiaohong Zhou, Hui Zhang, Jie Chen, Hongmei Deng, Min Shao, Mark C McmillsAbstract:Trans-2,3-dihydrofuran derivatives 3 or 4 substituted with a sulfonyl group were prepared with high chemoselectivity and good yields by [1+4]-addition reaction of α,β-unsaturated ketones 1 with Arsonium bromide 2 in CH2Cl2 in the presence of potassium carbonate at room temperature. The structures of the products were characterized by IR, MS, 1H NMR, elemental analysis and single crystal X-ray diffraction analysis. A mechanism for the formation of products was also proposed.
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an efficient and highly stereoselective synthesis of novel trifluoromethylated trans dihydrofuro 2 3 c pyrazoles using Arsonium ylides
Tetrahedron, 2012Co-Authors: Jiaping Zhang, Jie Chen, Hongmei Deng, Min Shao, Shuxin Yang, Kai Zhang, Hui ZhangAbstract:Abstract An efficient approach of highly stereoselective synthesis of novel trifluoromethylated trans-4,5-dihydrofuro[2,3-c]pyrazoles has been described. Arsonium bromides 1 reacted smoothly with the electron-deficient alkenes (Z)-4-aryl-1-phenyl-3-(trifluoromethyl)-1H-pyrozol-5(4H)-ones 2 to give products trans-dihydrofuro[2,3-c]pyrazoles 3 with high stereoselectivity and in good to excellent yields, using CH2Cl2 as solvent and K2CO3 as base.
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A Convenient Synthesis of Fluorine‐Containing trans‐1,2‐Cyclopropane Derivatives from Semistabilized Arsonium Ylides
Chinese Journal of Chemistry, 2011Co-Authors: Kaicheng Wu, Yali Chen, Hui Zhang, Xuyan Ma, Jie ChenAbstract:The fluorine-containing trans-1,2-cyclopropane derivatives 4ba–4dd were synthesized from the fluorine-containing electron-deficient alkenes 3a–3d with semistabilized Arsonium ylides 2b–2d, in biphasic system of dichloromethane-50% aqueous sodium hydroxide, generated in situ from the corresponding Arsonium salts 1b–1d at room temperature in good yields with high stereoselectivity. The structure of fluorine-containing trans-1,2-cyclopropane derivatives were also studied.
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a convenient synthesis of fluorine containing trans 1 2 cyclopropane derivatives from semistabilized Arsonium ylides
Chinese Journal of Chemistry, 2011Co-Authors: Kaicheng Wu, Yali Chen, Hui Zhang, Jie ChenAbstract:The fluorine-containing trans-1,2-cyclopropane derivatives 4ba–4dd were synthesized from the fluorine-containing electron-deficient alkenes 3a–3d with semistabilized Arsonium ylides 2b–2d, in biphasic system of dichloromethane-50% aqueous sodium hydroxide, generated in situ from the corresponding Arsonium salts 1b–1d at room temperature in good yields with high stereoselectivity. The structure of fluorine-containing trans-1,2-cyclopropane derivatives were also studied.
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
ChemInform, 2011Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:The reaction tolerates a wide range of functional groups at the Arsonium ylides and a variety of aromatic and furanyl substituents at the α,β-unsaturated ketones and proceeds with complete stereoselectivity.
Min Shao - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of sulfonyl substituted trans 2 3 dihydrofuran derivatives via reaction of Arsonium ylides with α β unsaturated ketones
Chemical Research in Chinese Universities, 2014Co-Authors: Xiaohong Zhou, Hui Zhang, Jie Chen, Hongmei Deng, Min Shao, Mark C McmillsAbstract:Trans-2,3-dihydrofuran derivatives 3 or 4 substituted with a sulfonyl group were prepared with high chemoselectivity and good yields by [1+4]-addition reaction of α,β-unsaturated ketones 1 with Arsonium bromide 2 in CH2Cl2 in the presence of potassium carbonate at room temperature. The structures of the products were characterized by IR, MS, 1H NMR, elemental analysis and single crystal X-ray diffraction analysis. A mechanism for the formation of products was also proposed.
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an efficient and highly stereoselective synthesis of novel trifluoromethylated trans dihydrofuro 2 3 c pyrazoles using Arsonium ylides
Tetrahedron, 2012Co-Authors: Jiaping Zhang, Jie Chen, Hongmei Deng, Min Shao, Shuxin Yang, Kai Zhang, Hui ZhangAbstract:Abstract An efficient approach of highly stereoselective synthesis of novel trifluoromethylated trans-4,5-dihydrofuro[2,3-c]pyrazoles has been described. Arsonium bromides 1 reacted smoothly with the electron-deficient alkenes (Z)-4-aryl-1-phenyl-3-(trifluoromethyl)-1H-pyrozol-5(4H)-ones 2 to give products trans-dihydrofuro[2,3-c]pyrazoles 3 with high stereoselectivity and in good to excellent yields, using CH2Cl2 as solvent and K2CO3 as base.
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
ChemInform, 2011Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:The reaction tolerates a wide range of functional groups at the Arsonium ylides and a variety of aromatic and furanyl substituents at the α,β-unsaturated ketones and proceeds with complete stereoselectivity.
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stereoselective synthesis of cyclopropyl indolyl ketones with indolylidene and Arsonium ylide
Journal of Heterocyclic Chemistry, 2010Co-Authors: Dong Zhou, Jie Chen, Hongmei Deng, Min ShaoAbstract:An efficient approach for stereoselective synthesis of cyclopropyl indolyl ketone from olefin and Arsonium ylied was achieved. Its advantages are of mild condition, high yield, and good stereoselectivity. In addition, the one-pot cycloproparation of olefins with bromides and triphenylarsine was studied. J. Heterocyclic Chem., (2010).
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
Tetrahedron, 2010Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:Abstract The reactions of Arsonium bromides with ( E )-α-trifluoromethylsulfonyl-α,β-unsaturated ketones in the presence of Cs 2 CO 3 or K 2 CO 3 proceeded smoothly under refluxing condition in dichloromethane (DCM) to give the corresponding trifluoromethylated trans -2,3-dihydrofurans in good to excellent yields with high stereoselectivity.
Jie Chen - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of sulfonyl substituted trans 2 3 dihydrofuran derivatives via reaction of Arsonium ylides with α β unsaturated ketones
Chemical Research in Chinese Universities, 2014Co-Authors: Xiaohong Zhou, Hui Zhang, Jie Chen, Hongmei Deng, Min Shao, Mark C McmillsAbstract:Trans-2,3-dihydrofuran derivatives 3 or 4 substituted with a sulfonyl group were prepared with high chemoselectivity and good yields by [1+4]-addition reaction of α,β-unsaturated ketones 1 with Arsonium bromide 2 in CH2Cl2 in the presence of potassium carbonate at room temperature. The structures of the products were characterized by IR, MS, 1H NMR, elemental analysis and single crystal X-ray diffraction analysis. A mechanism for the formation of products was also proposed.
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an efficient and highly stereoselective synthesis of novel trifluoromethylated trans dihydrofuro 2 3 c pyrazoles using Arsonium ylides
Tetrahedron, 2012Co-Authors: Jiaping Zhang, Jie Chen, Hongmei Deng, Min Shao, Shuxin Yang, Kai Zhang, Hui ZhangAbstract:Abstract An efficient approach of highly stereoselective synthesis of novel trifluoromethylated trans-4,5-dihydrofuro[2,3-c]pyrazoles has been described. Arsonium bromides 1 reacted smoothly with the electron-deficient alkenes (Z)-4-aryl-1-phenyl-3-(trifluoromethyl)-1H-pyrozol-5(4H)-ones 2 to give products trans-dihydrofuro[2,3-c]pyrazoles 3 with high stereoselectivity and in good to excellent yields, using CH2Cl2 as solvent and K2CO3 as base.
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A Convenient Synthesis of Fluorine‐Containing trans‐1,2‐Cyclopropane Derivatives from Semistabilized Arsonium Ylides
Chinese Journal of Chemistry, 2011Co-Authors: Kaicheng Wu, Yali Chen, Hui Zhang, Xuyan Ma, Jie ChenAbstract:The fluorine-containing trans-1,2-cyclopropane derivatives 4ba–4dd were synthesized from the fluorine-containing electron-deficient alkenes 3a–3d with semistabilized Arsonium ylides 2b–2d, in biphasic system of dichloromethane-50% aqueous sodium hydroxide, generated in situ from the corresponding Arsonium salts 1b–1d at room temperature in good yields with high stereoselectivity. The structure of fluorine-containing trans-1,2-cyclopropane derivatives were also studied.
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a convenient synthesis of fluorine containing trans 1 2 cyclopropane derivatives from semistabilized Arsonium ylides
Chinese Journal of Chemistry, 2011Co-Authors: Kaicheng Wu, Yali Chen, Hui Zhang, Jie ChenAbstract:The fluorine-containing trans-1,2-cyclopropane derivatives 4ba–4dd were synthesized from the fluorine-containing electron-deficient alkenes 3a–3d with semistabilized Arsonium ylides 2b–2d, in biphasic system of dichloromethane-50% aqueous sodium hydroxide, generated in situ from the corresponding Arsonium salts 1b–1d at room temperature in good yields with high stereoselectivity. The structure of fluorine-containing trans-1,2-cyclopropane derivatives were also studied.
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
ChemInform, 2011Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:The reaction tolerates a wide range of functional groups at the Arsonium ylides and a variety of aromatic and furanyl substituents at the α,β-unsaturated ketones and proceeds with complete stereoselectivity.
Hongmei Deng - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of sulfonyl substituted trans 2 3 dihydrofuran derivatives via reaction of Arsonium ylides with α β unsaturated ketones
Chemical Research in Chinese Universities, 2014Co-Authors: Xiaohong Zhou, Hui Zhang, Jie Chen, Hongmei Deng, Min Shao, Mark C McmillsAbstract:Trans-2,3-dihydrofuran derivatives 3 or 4 substituted with a sulfonyl group were prepared with high chemoselectivity and good yields by [1+4]-addition reaction of α,β-unsaturated ketones 1 with Arsonium bromide 2 in CH2Cl2 in the presence of potassium carbonate at room temperature. The structures of the products were characterized by IR, MS, 1H NMR, elemental analysis and single crystal X-ray diffraction analysis. A mechanism for the formation of products was also proposed.
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an efficient and highly stereoselective synthesis of novel trifluoromethylated trans dihydrofuro 2 3 c pyrazoles using Arsonium ylides
Tetrahedron, 2012Co-Authors: Jiaping Zhang, Jie Chen, Hongmei Deng, Min Shao, Shuxin Yang, Kai Zhang, Hui ZhangAbstract:Abstract An efficient approach of highly stereoselective synthesis of novel trifluoromethylated trans-4,5-dihydrofuro[2,3-c]pyrazoles has been described. Arsonium bromides 1 reacted smoothly with the electron-deficient alkenes (Z)-4-aryl-1-phenyl-3-(trifluoromethyl)-1H-pyrozol-5(4H)-ones 2 to give products trans-dihydrofuro[2,3-c]pyrazoles 3 with high stereoselectivity and in good to excellent yields, using CH2Cl2 as solvent and K2CO3 as base.
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
ChemInform, 2011Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:The reaction tolerates a wide range of functional groups at the Arsonium ylides and a variety of aromatic and furanyl substituents at the α,β-unsaturated ketones and proceeds with complete stereoselectivity.
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stereoselective synthesis of cyclopropyl indolyl ketones with indolylidene and Arsonium ylide
Journal of Heterocyclic Chemistry, 2010Co-Authors: Dong Zhou, Jie Chen, Hongmei Deng, Min ShaoAbstract:An efficient approach for stereoselective synthesis of cyclopropyl indolyl ketone from olefin and Arsonium ylied was achieved. Its advantages are of mild condition, high yield, and good stereoselectivity. In addition, the one-pot cycloproparation of olefins with bromides and triphenylarsine was studied. J. Heterocyclic Chem., (2010).
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highly stereoselective synthesis of trans 4 trifluoromethylsulfonyl 2 3 dihydrofurans from Arsonium ylides and e α trifluoromethylsulfonyl α β unsaturated ketones
Tetrahedron, 2010Co-Authors: Zhenqi Chen, Jie Chen, Hongmei Deng, Min Shao, Jiaping Zhang, Hui ZhangAbstract:Abstract The reactions of Arsonium bromides with ( E )-α-trifluoromethylsulfonyl-α,β-unsaturated ketones in the presence of Cs 2 CO 3 or K 2 CO 3 proceeded smoothly under refluxing condition in dichloromethane (DCM) to give the corresponding trifluoromethylated trans -2,3-dihydrofurans in good to excellent yields with high stereoselectivity.
Xian Huang - One of the best experts on this subject based on the ideXlab platform.
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α hypervalent iodine functionalized phosphonium and Arsonium ylides and their tandem reaction as umpolung reagents
Journal of Organic Chemistry, 2002Co-Authors: Zhi-zhen Huang, Xiao-chun Yu, Xian HuangAbstract:α-Hypervalent iodine functionalized phosphonium and Arsonium ylides 2 can be used as umpolung ylides to react with nucleophiles to give α-heteroatom substituted ylides 4 in good yields. The nucleophilic substitution−Wittig tandem reaction of 2 can occur smoothly to provide an efficient method for the synthesis of (Z)-α-halo-α,β-unsaturated enoates or enones 6, stereoselectively.
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tandem reaction of α hypervalent iodo functionalized phosphonium and Arsonium ylides as umpolung reagents
Tetrahedron Letters, 2002Co-Authors: Zhi-zhen Huang, Xiao-chun Yu, Xian HuangAbstract:α-Hypervalent iodo functionalized phosphonium and Arsonium ylides 2 can be used as umpolung ylides to react with nucleophiles to give α-heteroatom substituted ylides 4 in good yields. A tandem sequence of nucleophilic substitution then Wittig reaction occurs smoothly to form (Z)-α-halo-α,β-unsaturated esters 6, stereoselectively, in moderate to excellent yields.
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Synthesis of α-Phenylthioacylmethylene Triphenylarsoranes and their Wittig-type Reactions
Journal of Chemical Research-s, 1999Co-Authors: Guisheng Deng, Zhi-zhen Huang, Xiao-chun Yu, Xian HuangAbstract:α-Phenylthio acylmethylene triphenylarsoranes, the first stable α-thiyl Arsonium ylides, are prepared by phenylsulfenylation–transylidation reaction of the corresponding acylmethylene triphenylarsoranes with phenylsulfenyl chloride; Wittig reactions are carried out under mild reaction conditions on the Arsonium ylides to provide α-phenylthio-α,β-unsaturated ketones.
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a new synthesis of vinyl halides via α halo substituted semistabilized Arsonium ylide
Synthetic Communications, 1998Co-Authors: Zhi-zhen Huang, Xian HuangAbstract:Abstract As the first example 4 of the Wittig reaction of α-halo substituted semistabilized Arsonium ylide, we utilized this reaction to synthesize vinyl iodides 5.
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asymmetric wittig reaction of chiral Arsonium ylides i asymmetric olefination of 4 substituted cyclohexanones
Tetrahedron-asymmetry, 1997Co-Authors: Jinlong Wu, Xian HuangAbstract:Abstract Asymmetric Wittig-type olefination of 4-substituted cyclohexanones with chiral ligand-modified stable Arsonium ylides has been examined. The 8-phenylmenthol-derived chiral Arsonium ylide of 4 reacted with prochiral ketones 9a-d at −15°C to give the 4-substituted cyclohexylideneacetates 11a-d in 58–69% yield and in up to 80% diastereomeric excess (de).