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Seibei Miyake - One of the best experts on this subject based on the ideXlab platform.
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metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes Research and Clinical Practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P<0.01). Metformin therapy did not alter body weight, blood pressure, HbA1c, and serum lipids relative to the control. Thus, metformin attenuates the progression of CCA-IMT. This anti-atherogenic effect is not mediated through changes in classical cardiovascular risk factors.
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Metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes research and clinical practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P
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correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus
Metabolism-clinical and Experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P <.01). CCA-IMT in stroke patients was still significantly greater than controls after adjustment for age, sex, body mass index, and smoking status (P <.05). A 0.1-mm increase in CCA-IMT was associated with 1.80-fold increase in the odds ratio of stroke in diabetic patients (95%confidence interval [CI], 1.49 to 2.17; P <.01). Four independent factors were found to correlate significantly with CCA-IMT: age, systolic blood pressure, HbA(1c), and high-density lipoprotein (HDL) cholesterol. Thus, thickening of the intima-media of common carotid arteries is associated with ischemic stroke in type 2 diabetic patients. To prevent ischemic stroke, strict control of diabetes, hypertension, and dyslipidemia and monitoring of CCA-IMT may be important.
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Correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P
Kazunari Matsumoto - One of the best experts on this subject based on the ideXlab platform.
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metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes Research and Clinical Practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P<0.01). Metformin therapy did not alter body weight, blood pressure, HbA1c, and serum lipids relative to the control. Thus, metformin attenuates the progression of CCA-IMT. This anti-atherogenic effect is not mediated through changes in classical cardiovascular risk factors.
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Metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes research and clinical practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P
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correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus
Metabolism-clinical and Experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P <.01). CCA-IMT in stroke patients was still significantly greater than controls after adjustment for age, sex, body mass index, and smoking status (P <.05). A 0.1-mm increase in CCA-IMT was associated with 1.80-fold increase in the odds ratio of stroke in diabetic patients (95%confidence interval [CI], 1.49 to 2.17; P <.01). Four independent factors were found to correlate significantly with CCA-IMT: age, systolic blood pressure, HbA(1c), and high-density lipoprotein (HDL) cholesterol. Thus, thickening of the intima-media of common carotid arteries is associated with ischemic stroke in type 2 diabetic patients. To prevent ischemic stroke, strict control of diabetes, hypertension, and dyslipidemia and monitoring of CCA-IMT may be important.
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Correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P
Yasunori Sera - One of the best experts on this subject based on the ideXlab platform.
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metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes Research and Clinical Practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P<0.01). Metformin therapy did not alter body weight, blood pressure, HbA1c, and serum lipids relative to the control. Thus, metformin attenuates the progression of CCA-IMT. This anti-atherogenic effect is not mediated through changes in classical cardiovascular risk factors.
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Metformin attenuates progression of carotid Arterial Wall Thickness in patients with type 2 diabetes
Diabetes research and clinical practice, 2004Co-Authors: Kazunari Matsumoto, Yasunori Sera, Yasuyo Abe, Tan Tominaga, Yukitaka Yeki, Seibei MiyakeAbstract:To investigate the anti-atherogenic effect of metformin, we prospectively evaluated the effect of metformin treatment on common carotid intima-media Thickness (CCA-IMT) in patients with type 2 diabetes. A 2-year open prospective study was performed. Thirty-six patients were treated with metformin (500-750 mg per day). CCA-IMT was measured after 1- and 2-year treatment. Changes in CCA-IMT were compared with control patients. After 2-year metformin therapy, the progression of CCA-IMT was significantly less than 56 control patients (0.02+/-0.08 mm versus 0.07+/-0.08 mm, P
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correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus
Metabolism-clinical and Experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P <.01). CCA-IMT in stroke patients was still significantly greater than controls after adjustment for age, sex, body mass index, and smoking status (P <.05). A 0.1-mm increase in CCA-IMT was associated with 1.80-fold increase in the odds ratio of stroke in diabetic patients (95%confidence interval [CI], 1.49 to 2.17; P <.01). Four independent factors were found to correlate significantly with CCA-IMT: age, systolic blood pressure, HbA(1c), and high-density lipoprotein (HDL) cholesterol. Thus, thickening of the intima-media of common carotid arteries is associated with ischemic stroke in type 2 diabetic patients. To prevent ischemic stroke, strict control of diabetes, hypertension, and dyslipidemia and monitoring of CCA-IMT may be important.
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Correlation between common carotid Arterial Wall Thickness and ischemic stroke in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental, 2002Co-Authors: Kazunari Matsumoto, Yasunori Sera, Hideki Nakamura, Yukitaka Ueki, Seibei MiyakeAbstract:If a strong association between intima-media Thickness of the common carotid artery (CCA-IMT) and ischemic stroke can be determined in diabetic subjects, it may be a useful predictor to help identify patients at high risk of ischemic stroke. To investigate the relative contribution of CCA-IMT to ischemic stroke in patients with type 2 diabetes, we measured CCA-IMT and other conventional risk factors in 438 Japanese patients with type 2 diabetes, including 45 with ischemic stroke and 393 controls. Stroke patients were characteristically and significantly older with higher body mass index, longer duration of diabetes, likely to be smokers, higher blood pressure, and higher total cholesterol compared with the controls. CCA-IMT in stroke patients (1.23 +/- 0.04 mm) was significantly greater than in control patients (0.95 +/- 0.01 mm, P
Tetsuo Shoji - One of the best experts on this subject based on the ideXlab platform.
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Association between Plasma Angiopoietin-Like Protein 3 and Arterial Wall Thickness in Healthy Subjects
Journal of vascular research, 2006Co-Authors: Sawako Hatsuda, Hidenori Koyama, Shinya Fukumoto, Masanori Emoto, Tetsuo Shoji, Kayo Shinohara, Eiji Kimoto, Katsuhito Mori, Yoshiki NishizawaAbstract:Background: Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental mo
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Arterial Wall stiffness is associated with peripheral circulation in patients with type 2 diabetes
Atherosclerosis, 2003Co-Authors: Akane Kizu, Miyoko Komatsu, Takaaki Maeno, Hidenori Koyama, Shinya Fukumoto, Masanori Emoto, Masaaki Inaba, Tetsuo Shoji, Shinji Tanaka, Atsushi ShioiAbstract:Abstract The prevalence of peripheral vascular disease (PVD) in diabetic patients is manyfold higher than that of age- and sex-matched nondiabetic subjects. This study was designed to evaluate the relationship between quantitatively determined peripheral circulation in the lower extremities and Arterial Wall Thickness or stiffness in 68 patients with type 2 diabetes. Peripheral circulation during treadmill-exercise was monitored by transcutaneous oxygen tension (TcPO 2 ) and was expressed as percentage of post-exercise TcPO 2 adjusted by that of pre-exercise (TcPO 2 index). Arterial Wall Thickness (intima-media Thickness; IMT) and stiffness (stiffness β) were measured by ultrasonography. TcPO 2 index was negatively ( r =−0.350, P =0.0007) correlated with stiffness β, not with IMT, of the femoral artery. In patients without insulin therapy ( n =52), both fasting plasma insulin concentration ( r =−0.323, P =0.0023) and HOMA IR, an insulin resistance index, ( r =−0.281, P =0.0084) were negatively correlated with TcPO 2 index. Multiple regression analyses showed that association of stiffness β of the femoral artery or HOMA IR with the TcPO 2 index was independent of other factors including age, smoking index, ankle brachial pressure index and IMT of femoral artery. Thus, Arterial Wall stiffness of femoral artery appears to be a major determinant of peripheral circulation in patients with type 2 diabetes.
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Arterial Wall Thickness is associated with insulin resistance in type 2 diabetic patients.
Journal of atherosclerosis and thrombosis, 2003Co-Authors: Shigehiko Fujiwara, Miyoko Komatsu, Hidenori Koyama, Masanori Emoto, Masaaki Inaba, Tetsuo Shoji, Koka Motoyama, Tomoaki Morioka, Yoshiki NishizawaAbstract:The aim of the present study was to investigate the independent association of the intimal-medial Thickness of carotid and femoral arteries (CA-IMT and FA-IMT), a marker of atheroscelosis, with insulin resistance in type 2 diabetic patients. We evaluated CA-IMT and FA-IMT by high-resolution ultrasonography and insulin resistance determined by euglycemic hyperinsulinemic clamp in 119 type 2 diabetic subjects, 71 males and 48 females (age, 54 +/- 12 (SD) years). In simple regression analyses, CA-IMT and FA-IMT were significantly inversely correlated with insulin sensitivity index (CA-IMT, r = -0.225, p = 0.010; FA-IMT, r = -0.186, p = 0.043, respectively). Multiple regression analysis was performed with the logarithm of CA-IMT or FA-IMT as a dependent variable and insulin sensitivity index as an independent variable along with known clinical risk factors. Insulin sensitivity index exhibited a significant independent contribution to log (CA-IMT) (beta = -0.204, p = 0.033) and to log (FA-IMT) (beta = -0.237, p = 0.010) in these models (CA-IMT, R(2) = 0.347, p < 0.0001; FA-IMT, R(2) = 0.398, p < 0.0001, respectively). In conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes.
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Effect of polymorphism of apolipoprotein E and angiotensin-converting enzyme genes on Arterial Wall Thickness
Diabetes, 1997Co-Authors: Kyoko Kogawa, Tetsuo Shoji, Yoshiki Nishizawa, Masayuki Hosoi, Takahiko Kawagishi, Kiyoshi Maekawa, Yasuhisa Okuno, Hirotoshi MoriiAbstract:We examined the association between the polymorphism of the apolipoprotein E (apoE) and the ACE genes and the intima-media Thickness (IMT) of the carotid and femoral arteries measured using ultrasonography. The values of IMT of each artery were significantly higher in NIDDM patients (n = 356) than in control subjects (n = 235). The E4 allele or the D allele did not affect clinical characteristics, including age, fasting plasma glucose, total cholesterol, HDL cholesterol, LDL cholesterol, or blood pressure, in NIDDM or control subjects. No difference in the carotid IMT value was noted among the apoE genotypes in control or diabetic subjects. The carotid IMT was significantly higher in diabetic patients with the DD genotype (1.200 ± 0.586 mm) than in those with the II genotypes (0.990 ± 0.364 mm). Neither the E4 allele nor the D allele affected the femoral IMT in control or diabetic subjects. Multiple regression analysis demonstrated that the carotid IMT of NIDDM patients was associated with age, the D allele, and LDL cholesterol but not with the E4 allele, whereas that of control subjects was associated with age, sex, systolic blood pressure, LDL cholesterol, and HDL cholesterol, inversely. These results suggested that the E4 allele was not associated with the carotid or femoral IMTs, but that the D allele was statistically associated with carotid IMT in NIDDM patients but not control subjects. However, since the association was weak (2.3% explanatory power), its biological significance remains to be determined.
Daniel J. Green - One of the best experts on this subject based on the ideXlab platform.
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corrigendum to local and systemic effects of leg cycling training on Arterial Wall Thickness in healthy humans atherosclerosis 229 2 2013 282 286
Atherosclerosis, 2014Co-Authors: Dick H. J. Thijssen, Ellen A. Dawson, Inge C.l. Van Den Munckhof, Gurpreet K. Birk, Daniel J. Green, Timothy N CableAbstract:Corrigendum to “Local and systemic effects of leg cycling training on Arterial Wall Thickness in healthy humans” [Atherosclerosis 229 (2) (2013) 282e286] Dick H.J. Thijssen *, Ellen A. Dawson , Inge C.L. van den Munckhof , Gurpreet K. Birk , N. Timothy Cable , Daniel J. Green a,c Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, United Kingdom Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands c School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia 6009, Australia
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Corrigendum to “Local and systemic effects of leg cycling training on Arterial Wall Thickness in healthy humans” [Atherosclerosis 229 (2) (2013) 282–286]
Atherosclerosis, 2014Co-Authors: Dick H. J. Thijssen, Ellen A. Dawson, Inge C.l. Van Den Munckhof, Gurpreet K. Birk, N. Timothy Cable, Daniel J. GreenAbstract:Corrigendum to “Local and systemic effects of leg cycling training on Arterial Wall Thickness in healthy humans” [Atherosclerosis 229 (2) (2013) 282e286] Dick H.J. Thijssen *, Ellen A. Dawson , Inge C.L. van den Munckhof , Gurpreet K. Birk , N. Timothy Cable , Daniel J. Green a,c Research Institute for Sport and Exercise Science, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, United Kingdom Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands c School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia 6009, Australia
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local and systemic effects of leg cycling training on Arterial Wall Thickness in healthy humans
Atherosclerosis, 2013Co-Authors: Dick H. J. Thijssen, Ellen A. Dawson, Gurpreet K. Birk, Daniel J. Green, Timothy N Cable, Inge C L Van Den MunckhofAbstract:Abstract Exercise training is associated with direct effects on conduit artery function and structure. Cross-sectional studies suggest the presence of systemic changes in Wall Thickness as a result of exercise in healthy subjects, but no previous study has examined this question in humans undertaking exercise training. Objective To examine the change in superficial femoral (SFA, i.e. local effect) and carotid (CA, i.e. systemic effect) artery Wall Thickness across 8 weeks of lower limb cycle training in healthy young men. Methods Fourteen healthy young male subjects were assigned to an 8-week training study of cycling exercise ( n = 9) or a control period ( n = 5). Before, during (2, 4 and 6 weeks) and after training, SFA and CA Wall Thickness was examined using automated edge-detection of high resolution ultrasound images. We also measured resting diameter and calculated the Wall:lumen(W:L)-ratio. Results Exercise training did not alter CA or SFA baseline diameter ( P = 0.14), but was associated with gradual, consistent and significant decreases in Wall Thickness and W:L-ratio in both the CA and SFA ( P P = 0.29 and 0.12, respectively). No changes in artery diameter, Wall Thickness or W:L-ratio were apparent in controls (0.82, 0.38 and 0.52, respectively). Conclusion We found that cycle exercise training in healthy young individuals is associated with modest, but significant, decreases in Wall Thickness in the superficial femoral and carotid arteries. These findings suggest that exercise training causes systemic adaptation of the Arterial Wall in healthy young subjects.
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Impact of age and sex on carotid and peripheral Arterial Wall Thickness in humans.
Acta physiologica (Oxford England), 2012Co-Authors: I. Van Den Munckhof, Daniel J. Green, Nigel Timothy Cable, Ralph R. Scholten, Maria T. E. Hopman, Dick H. J. ThijssenAbstract:BACKGROUND: Although previous studies have reported age-related Wall thickening in carotid arteries, it is not clear whether this is a systemic phenomenon which is also apparent in peripheral conduit arteries or whether conduit Wall Thickness (WT) changes occur to a similar degree in men and women. AIM: To determine whether sex modifies the impact of ageing on WT or Wall-to-lumen ratio (W:L) in atherosclerosis-prone (i.e. carotid artery, femoral, superficial femoral, popliteal artery) and atherosclerosis-resistant (i.e. brachial artery) conduit arteries. METHODS: We included 30 young (23 +/- 2 year; 15M : 15F) and 31 older (70 +/- 5 year; 18M : 13F) healthy subjects. High-resolution ultrasound was used to measure diameter, WT and Wall-to-lumen ratio (W/L) in all arteries. RESULTS: Older subjects had increased WT and W/L in the carotid, femoral, superficial femoral, popliteal and brachial arteries (all P < 0.05). Compared with women, men demonstrated larger diameter and WT (both P < 0.01) across all arteries. Sex did not impact upon age-related changes in WT or W/L (P = 0.39 and 0.43 respectively). CONCLUSION: Our data suggest that age-related Wall thickening, evident in the carotid artery, is also apparent in the arteries of the upper and lower limbs. The impact of age on Wall thickening did not differ between men and women. These data support the presence of systemic increases in WT and W/L with age in apparently healthy humans, independent of sex.
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Impact of exercise training on Arterial Wall Thickness in humans
Clinical science (London England : 1979), 2011Co-Authors: Dick H. J. Thijssen, Nigel Timothy Cable, Daniel J. GreenAbstract:Thickening of the carotid artery Wall has been adopted as a surrogate marker of pre-clinical atherosclerosis, which is strongly related to increased cardiovascular risk. The cardioprotective effects of exercise training, including direct effects on vascular function and lumen dimension, have been consistently reported in asymptomatic subjects and those with cardiovascular risk factors and diseases. In the present review, we summarize evidence pertaining to the impact of exercise and physical activity on Arterial Wall remodelling of the carotid artery and peripheral arteries in the upper and lower limbs. We consider the potential role of exercise intensity, duration and modality in the context of putative mechanisms involved in Wall remodelling, including haemodynamic forces. Finally, we discuss the impact of exercise training in terms of primary prevention of Wall thickening in healthy subjects and remodelling of arteries in subjects with existing cardiovascular disease and risk factors.