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Patrick W. Serruys – One of the best experts on this subject based on the ideXlab platform.

  • Left main coronary Artery Disease: pathophysiology, diagnosis, and treatment
    Nature Reviews Cardiology, 2018
    Co-Authors: Carlos Collet, Davide Capodanno, Yoshinobu Onuma, Adrian Banning, Gregg W. Stone, David P. Taggart, Joseph Sabik, Patrick W. Serruys

    Abstract:

    In this Review, Serruys and colleagues describe the pathophysiology of unprotected left main coronary Artery Disease, discuss novel diagnostic approaches in light of new imaging techniques, and describe risk stratification models to help in the decision-making process for determining the best revascularization strategy in these patients. The advent of coronary angiography in the 1960s allowed for the risk stratification of patients with stable angina. Patients with unprotected left main coronary Artery Disease have an increased risk of death related to the large amount of myocardium supplied by this vessel. Although coronary angiography remains the preferred imaging modality for the evaluation of left main coronary Artery stenosis, this technique has important limitations. Angiograms of the left main coronary Artery segment can be difficult to interpret, and almost one-third of patients can be misclassified when fractional flow reserve is used as the reference. In patients with clinically significant unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy and has been regarded as the treatment of choice for unprotected left main coronary Artery Disease. Two large-scale clinical trials published in 2016 support the usefulness of catheter-based revascularization in selected patients with unprotected left main coronary Artery Disease. In this Review, we describe the pathophysiology of unprotected left main coronary Artery Disease, discuss diagnostic approaches in light of new noninvasive and invasive imaging techniques, and detail risk stratification models to aid the Heart Team in the decision-making process for determining the best revascularization strategy for these patients. Patients with unprotected left main coronary Artery Disease have an increased risk of death Although coronary angiography remains the preferred diagnostic imaging modality for these patients, adjunctive anatomical and physiological methods are often required to assess the clinical significance of the lesion In patients with unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy The EXCEL and NOBLE trials demonstrated the safety and efficacy of percutaneous coronary intervention compared with CABG surgery in selected patients with unprotected left main coronary Artery Disease Long-term clinical follow-up is required to define the optimal clinical management of patients with unprotected left main coronary Artery Disease

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Szechiński J – One of the best experts on this subject based on the ideXlab platform.

  • Reactive hyperinsulinemia in coronary Artery Disease. 1
    Polskie Archiwum Medycyny Wewnetrznej, 1993
    Co-Authors: Zajac A, Szechiński J

    Abstract:

    Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease. Classical risk factors of coronary Artery Disease as well as glycaemia and insulinemia during the oral glucose tolerance test was investigated. Positive correlation between coronary Artery Disease and classical risk factors as well as reactive insulin level was found with normal reactive glycemia.

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  • Reactive hyperinsulinemia in coronary Artery Disease. 2. Correlation between reactive hyperinsulinemia and other risk factors of coronary Artery Disease
    Polskie Archiwum Medycyny Wewnetrznej, 1993
    Co-Authors: Zajac A, Szechiński J

    Abstract:

    Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease as well as glycaemia and insulinaemia were studied during the oral glucose tolerance test. The results show positive correlation between hyperinsulinemia and some classical risk factors of coronary Artery Disease.

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Carlos Collet – One of the best experts on this subject based on the ideXlab platform.

  • Left main coronary Artery Disease: pathophysiology, diagnosis, and treatment
    Nature Reviews Cardiology, 2018
    Co-Authors: Carlos Collet, Davide Capodanno, Yoshinobu Onuma, Adrian Banning, Gregg W. Stone, David P. Taggart, Joseph Sabik, Patrick W. Serruys

    Abstract:

    In this Review, Serruys and colleagues describe the pathophysiology of unprotected left main coronary Artery Disease, discuss novel diagnostic approaches in light of new imaging techniques, and describe risk stratification models to help in the decision-making process for determining the best revascularization strategy in these patients. The advent of coronary angiography in the 1960s allowed for the risk stratification of patients with stable angina. Patients with unprotected left main coronary Artery Disease have an increased risk of death related to the large amount of myocardium supplied by this vessel. Although coronary angiography remains the preferred imaging modality for the evaluation of left main coronary Artery stenosis, this technique has important limitations. Angiograms of the left main coronary Artery segment can be difficult to interpret, and almost one-third of patients can be misclassified when fractional flow reserve is used as the reference. In patients with clinically significant unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy and has been regarded as the treatment of choice for unprotected left main coronary Artery Disease. Two large-scale clinical trials published in 2016 support the usefulness of catheter-based revascularization in selected patients with unprotected left main coronary Artery Disease. In this Review, we describe the pathophysiology of unprotected left main coronary Artery Disease, discuss diagnostic approaches in light of new noninvasive and invasive imaging techniques, and detail risk stratification models to aid the Heart Team in the decision-making process for determining the best revascularization strategy for these patients. Patients with unprotected left main coronary Artery Disease have an increased risk of death Although coronary angiography remains the preferred diagnostic imaging modality for these patients, adjunctive anatomical and physiological methods are often required to assess the clinical significance of the lesion In patients with unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy The EXCEL and NOBLE trials demonstrated the safety and efficacy of percutaneous coronary intervention compared with CABG surgery in selected patients with unprotected left main coronary Artery Disease Long-term clinical follow-up is required to define the optimal clinical management of patients with unprotected left main coronary Artery Disease

    Free Register to Access Article