The Experts below are selected from a list of 396381 Experts worldwide ranked by ideXlab platform
Patrick W. Serruys - One of the best experts on this subject based on the ideXlab platform.
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Left main coronary Artery Disease: pathophysiology, diagnosis, and treatment
Nature Reviews Cardiology, 2018Co-Authors: Carlos Collet, Davide Capodanno, Yoshinobu Onuma, Adrian Banning, Gregg W. Stone, David P. Taggart, Joseph Sabik, Patrick W. SerruysAbstract:In this Review, Serruys and colleagues describe the pathophysiology of unprotected left main coronary Artery Disease, discuss novel diagnostic approaches in light of new imaging techniques, and describe risk stratification models to help in the decision-making process for determining the best revascularization strategy in these patients. The advent of coronary angiography in the 1960s allowed for the risk stratification of patients with stable angina. Patients with unprotected left main coronary Artery Disease have an increased risk of death related to the large amount of myocardium supplied by this vessel. Although coronary angiography remains the preferred imaging modality for the evaluation of left main coronary Artery stenosis, this technique has important limitations. Angiograms of the left main coronary Artery segment can be difficult to interpret, and almost one-third of patients can be misclassified when fractional flow reserve is used as the reference. In patients with clinically significant unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy and has been regarded as the treatment of choice for unprotected left main coronary Artery Disease. Two large-scale clinical trials published in 2016 support the usefulness of catheter-based revascularization in selected patients with unprotected left main coronary Artery Disease. In this Review, we describe the pathophysiology of unprotected left main coronary Artery Disease, discuss diagnostic approaches in light of new noninvasive and invasive imaging techniques, and detail risk stratification models to aid the Heart Team in the decision-making process for determining the best revascularization strategy for these patients. Patients with unprotected left main coronary Artery Disease have an increased risk of death Although coronary angiography remains the preferred diagnostic imaging modality for these patients, adjunctive anatomical and physiological methods are often required to assess the clinical significance of the lesion In patients with unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy The EXCEL and NOBLE trials demonstrated the safety and efficacy of percutaneous coronary intervention compared with CABG surgery in selected patients with unprotected left main coronary Artery Disease Long-term clinical follow-up is required to define the optimal clinical management of patients with unprotected left main coronary Artery Disease
Szechiński J - One of the best experts on this subject based on the ideXlab platform.
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Reactive hyperinsulinemia in coronary Artery Disease. 1
Polskie Archiwum Medycyny Wewnetrznej, 1993Co-Authors: Zajac A, Szechiński JAbstract:Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease. Classical risk factors of coronary Artery Disease as well as glycaemia and insulinemia during the oral glucose tolerance test was investigated. Positive correlation between coronary Artery Disease and classical risk factors as well as reactive insulin level was found with normal reactive glycemia.
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Reactive hyperinsulinemia in coronary Artery Disease. 2. Correlation between reactive hyperinsulinemia and other risk factors of coronary Artery Disease
Polskie Archiwum Medycyny Wewnetrznej, 1993Co-Authors: Zajac A, Szechiński JAbstract:Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease as well as glycaemia and insulinaemia were studied during the oral glucose tolerance test. The results show positive correlation between hyperinsulinemia and some classical risk factors of coronary Artery Disease.
Carlos Collet - One of the best experts on this subject based on the ideXlab platform.
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Left main coronary Artery Disease: pathophysiology, diagnosis, and treatment
Nature Reviews Cardiology, 2018Co-Authors: Carlos Collet, Davide Capodanno, Yoshinobu Onuma, Adrian Banning, Gregg W. Stone, David P. Taggart, Joseph Sabik, Patrick W. SerruysAbstract:In this Review, Serruys and colleagues describe the pathophysiology of unprotected left main coronary Artery Disease, discuss novel diagnostic approaches in light of new imaging techniques, and describe risk stratification models to help in the decision-making process for determining the best revascularization strategy in these patients. The advent of coronary angiography in the 1960s allowed for the risk stratification of patients with stable angina. Patients with unprotected left main coronary Artery Disease have an increased risk of death related to the large amount of myocardium supplied by this vessel. Although coronary angiography remains the preferred imaging modality for the evaluation of left main coronary Artery stenosis, this technique has important limitations. Angiograms of the left main coronary Artery segment can be difficult to interpret, and almost one-third of patients can be misclassified when fractional flow reserve is used as the reference. In patients with clinically significant unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy and has been regarded as the treatment of choice for unprotected left main coronary Artery Disease. Two large-scale clinical trials published in 2016 support the usefulness of catheter-based revascularization in selected patients with unprotected left main coronary Artery Disease. In this Review, we describe the pathophysiology of unprotected left main coronary Artery Disease, discuss diagnostic approaches in light of new noninvasive and invasive imaging techniques, and detail risk stratification models to aid the Heart Team in the decision-making process for determining the best revascularization strategy for these patients. Patients with unprotected left main coronary Artery Disease have an increased risk of death Although coronary angiography remains the preferred diagnostic imaging modality for these patients, adjunctive anatomical and physiological methods are often required to assess the clinical significance of the lesion In patients with unprotected left main coronary Artery Disease, surgical revascularization was shown to improve survival compared with medical therapy The EXCEL and NOBLE trials demonstrated the safety and efficacy of percutaneous coronary intervention compared with CABG surgery in selected patients with unprotected left main coronary Artery Disease Long-term clinical follow-up is required to define the optimal clinical management of patients with unprotected left main coronary Artery Disease
Heinz Drexel - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of type 2 diabetes is higher in peripheral Artery Disease than in coronary Artery Disease patients.
Diabetes & vascular disease research, 2015Co-Authors: Günther Silbernagel, Philipp Rein, Christoph H. Saely, Rolf P. Engelberger, Torsten Willenberg, Nils Kucher, Iris Baumgartner, Heinz DrexelAbstract:Type 2 diabetes mellitus and pre-diabetes are risk factors for atherosclerosis and are highly prevalent in patients with coronary Artery Disease. However, the prevalence of impaired glucose metabolism in patients with peripheral Artery Disease is not as well elucidated. We aimed at comparing prevalence rates of type 2 diabetes mellitus and pre-diabetes, which were diagnosed according to the current American Diabetes Association criteria, among 364 patients with peripheral Artery Disease, 529 patients with coronary Artery Disease and 383 controls. The prevalence of type 2 diabetes mellitus in peripheral Artery Disease patients was 49.7%. It was significantly higher in these patients than in coronary Artery Disease patients (34.4%; p < 0.001) and controls (21.4%; p < 0.001). Adjusted for sex, age and body mass index, odds ratios for type 2 diabetes mellitus were 2.0 (95% confidence interval 1.5–2.6) comparing the peripheral Artery Disease group with the coronary Artery Disease group (p < 0.001) and 4.0 (2.8–5.8) comparing the peripheral Artery Disease group with controls (p < 0.001). The prevalence of pre-diabetes among non-diabetic subjects was high in all three study groups (64.5% in peripheral Artery Disease patients, 63.4% in coronary Artery Disease patients and 61.8% in controls), without significant between-group differences. In conclusion, the prevalence of type 2 diabetes mellitus is even higher in peripheral Artery Disease patients than in coronary Artery Disease patients. This observation underlines the need to consider impaired glucose regulation in the management of peripheral Artery Disease.
Zajac A - One of the best experts on this subject based on the ideXlab platform.
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Reactive hyperinsulinemia in coronary Artery Disease. 1
Polskie Archiwum Medycyny Wewnetrznej, 1993Co-Authors: Zajac A, Szechiński JAbstract:Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease. Classical risk factors of coronary Artery Disease as well as glycaemia and insulinemia during the oral glucose tolerance test was investigated. Positive correlation between coronary Artery Disease and classical risk factors as well as reactive insulin level was found with normal reactive glycemia.
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Reactive hyperinsulinemia in coronary Artery Disease. 2. Correlation between reactive hyperinsulinemia and other risk factors of coronary Artery Disease
Polskie Archiwum Medycyny Wewnetrznej, 1993Co-Authors: Zajac A, Szechiński JAbstract:Two groups of patients were studied: group with stable coronary Artery Disease and group without the coronary Artery Disease as well as glycaemia and insulinaemia were studied during the oral glucose tolerance test. The results show positive correlation between hyperinsulinemia and some classical risk factors of coronary Artery Disease.
