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Yongting Wang - One of the best experts on this subject based on the ideXlab platform.
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optimizing suture middle cerebral Artery occlusion model in c57bl 6 mice circumvents posterior communicating Artery Dysplasia
Journal of Neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
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Optimizing suture middle cerebral Artery occlusion model in C57BL/6 mice circumvents posterior communicating Artery Dysplasia.
Journal of neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
Pierrefrancois Plouin - One of the best experts on this subject based on the ideXlab platform.
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high prevalence of multiple arterial bed lesions in patients with fibromuscular Dysplasia the arcadia registry assessment of renal and cervical Artery Dysplasia
Hypertension, 2017Co-Authors: Pierrefrancois Plouin, Jeanphilippe Baguet, Frederic Thony, Olivier Ormezzano, Arshid Azarine, Francois Silhol, C Oppenheim, Beatrice Bouhanick, Louis Boyer, Alexandre PersuAbstract:Fibromuscular Dysplasia (FMD) commonly affects the renal and cervical arteries but has been described to affect other vascular beds as well. The prevalence of and clinical characteristics associated with multisite FMD (string-of-beds or focal stenoses affecting at least 2 vascular beds) are not known. In the prospective ARCADIA registry (Assessment of Renal and Cervical Artery Dysplasia), symptomatic patients with renal Artery (RA) FMD underwent tomographic- or magnetic resonance-angiography from the aortic arch to the intracranial arteries and those with cervical FMD from the diaphragm to the pelvis. Of 469 patients (84.0% women), 225 (48.0%) had multisite FMD. In addition, 86 of 244 patients with single-site disease had dissections or aneurisms affecting other vascular beds, totaling 311 patients (66.3%) with lesions in >1 vascular bed. Among patients with a cerebrovascular presentation, the prevalence of RA lesions was higher in patients with than in those without hypertension (odds ratio, 3.4; 95% confidence interval, 1.99–6.15). Among patients with a renal presentation, the prevalence of cervical lesions was higher in patients with bilateral than in those with unilateral RA lesions (odds ratio, 1.9; 95% confidence interval, 0.99–3.57). In conclusion, FMD is a systemic arterial disease. At least 2 vascular beds were affected by dysplastic stenoses in 48.0% of cases and by dysplastic stenoses, aneurysms, and dissections in 66.1% of cases. RA imaging should be proposed to hypertensive patients with a cerebrovascular presentation. Cervical Artery imaging should be considered in patients with a renal presentation and bilateral RA lesions. Clinical Trial Registration— URL: www.Clinicaltrials.gov. Unique identifier: NCT02884141.
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Revisiting Fibromuscular Dysplasia: Rationale of the European Fibromuscular Dysplasia Initiative.
Hypertension (Dallas Tex. : 1979), 2016Co-Authors: Alexandre Persu, Pierrefrancois Plouin, Patricia Van Der Niepen, Emmanuel Touzé, Sofie Gevaert, E. Berra, Pamela Mace, Xavier JeunemaitreAbstract:Fibromuscular Dysplasia (FMD) has been defined as an idiopathic, segmental, nonatherosclerotic, and noninflammatory disease of the musculature of arterial walls, leading to stenosis of small- and medium-sized arteries.1,2 Furthermore, to confirm the diagnosis of FMD, arterial diseases of monogenic origin, inflammatory arterial diseases, and the use of arterial vasoconstrictors have to be excluded. Renal FMD may lead to renovascular hypertension, less frequently renal Artery dissection, renal infarction, and aneurysm rupture.1 Cervico-cephalic FMD can result in ischemic or hemorrhagic stroke, cervical Artery dissection, and may be also associated with intracerebral aneurysms and risk of subarachnoid hemorrhage.3 In some patients, the diagnosis of FMD can lead to invasive procedures, such as percutaneous angioplasty, reconstructive surgery, or intracranial aneurysm clipping. Thus, both the disease and its treatment can lead to significant morbidity and mortality.1 The French4–6 and the US7–10 registries have led to a reappraisal of the frequency, demographic characteristics, classification, pathophysiology, and management of FMD. The face of the disease is evolving from a rare disease of renal arteries accounting for a minority of cases of secondary hypertension in young women to a "systemic" vascular disease affecting renal and also cervico-cephalic, coronary, and iliac arteries1,11 (Table 1). In various cohorts, despite incomplete exploration, mostly driven by symptoms and clinical complaints, FMD of ≥2 vascular beds was consistently found in >30% of cases.1,7,12,13 The French ARCADIA (Assessment of Renal and Cervical Artery Dysplasia) registry, which required a standardized vascular work-up in all patients, will soon provide a more precise estimate of the frequency of diffuse FMD. Besides female sex and repeated mechanical trauma because of increased kidney mobility,14 recent works suggest a contribution of smoking6 in progression of the …
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Diagnosis and treatment of renal Artery stenosis
Nature Reviews Nephrology, 2010Co-Authors: Pierrefrancois PlouinAbstract:Atherosclerotic renovascular disease is a cardiovascular condition that is associated with renal Artery stenosis (RAS); treatment with statins and renin–angiotensin antagonists can provide cardiovascular protection Renal impairment associated with atherosclerotic RAS is both a marker and a risk factor for cardiovascular disease Patients with atherosclerotic RAS and a stable condition should be treated first with medication Renal Artery stenting is not recommended for most patients with atherosclerotic RAS, but it might be beneficial for those with refractory hypertension or rapidly progressing renal or cardiac dysfunction Patients with fibromuscular Dysplasia of the renal Artery usually have renovascular hypertension without renal failure or associated vascular disease A reduction in the diameter of the renal arteries can lead to hypertension, renal dysfunction and/or pulmonary edema. About 90% of patients with renal Artery stenosis have atherosclerosis, and 10% have fibromuscular Dysplasia. Atherosclerotic renal Artery stenosis is a common condition that typically occurs in patients at high risk of cardiovascular disease with coexistent vascular disease at nonrenal sites. Patients who undergo revascularization to treat hypertension associated with atherosclerotic stenosis need to continue medication with statins, antiplatelet agents and renin–angiotensin antagonists after the procedure to prevent renal and cardiovascular events. Two recent trials compared renal outcomes in patients with atherosclerotic stenosis who were treated with antihypertensive medication plus stenting with those in patients who were treated with medication alone. Available results favor a conservative approach (medication only) for most patients with atherosclerotic renal Artery stenosis. These results, however, concern patients with stable clinical conditions and, in many cases, only moderate renal Artery lesions. Blood pressure outcome after angioplasty is more favorable in patients with fibromuscular renal Artery disease, who usually do not have renal failure, than in those with atherosclerosis. Narrowing of the renal Artery reduces renal perfusion and can lead to hypertension, renal dysfunction and/or pulmonary edema. In this Review, Plouin and Bax discuss the diagnosis and management of the two most common types of renal Artery stenosis: atherosclerotic renal Artery stenosis and fibromuscular renal Artery Dysplasia. The authors also describe recent data from randomized, controlled trials of patients with atherosclerotic renal Artery stenosis.
Falei Yuan - One of the best experts on this subject based on the ideXlab platform.
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optimizing suture middle cerebral Artery occlusion model in c57bl 6 mice circumvents posterior communicating Artery Dysplasia
Journal of Neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
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Optimizing suture middle cerebral Artery occlusion model in C57BL/6 mice circumvents posterior communicating Artery Dysplasia.
Journal of neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
Alexandre Persu - One of the best experts on this subject based on the ideXlab platform.
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high prevalence of multiple arterial bed lesions in patients with fibromuscular Dysplasia the arcadia registry assessment of renal and cervical Artery Dysplasia
Hypertension, 2017Co-Authors: Pierrefrancois Plouin, Jeanphilippe Baguet, Frederic Thony, Olivier Ormezzano, Arshid Azarine, Francois Silhol, C Oppenheim, Beatrice Bouhanick, Louis Boyer, Alexandre PersuAbstract:Fibromuscular Dysplasia (FMD) commonly affects the renal and cervical arteries but has been described to affect other vascular beds as well. The prevalence of and clinical characteristics associated with multisite FMD (string-of-beds or focal stenoses affecting at least 2 vascular beds) are not known. In the prospective ARCADIA registry (Assessment of Renal and Cervical Artery Dysplasia), symptomatic patients with renal Artery (RA) FMD underwent tomographic- or magnetic resonance-angiography from the aortic arch to the intracranial arteries and those with cervical FMD from the diaphragm to the pelvis. Of 469 patients (84.0% women), 225 (48.0%) had multisite FMD. In addition, 86 of 244 patients with single-site disease had dissections or aneurisms affecting other vascular beds, totaling 311 patients (66.3%) with lesions in >1 vascular bed. Among patients with a cerebrovascular presentation, the prevalence of RA lesions was higher in patients with than in those without hypertension (odds ratio, 3.4; 95% confidence interval, 1.99–6.15). Among patients with a renal presentation, the prevalence of cervical lesions was higher in patients with bilateral than in those with unilateral RA lesions (odds ratio, 1.9; 95% confidence interval, 0.99–3.57). In conclusion, FMD is a systemic arterial disease. At least 2 vascular beds were affected by dysplastic stenoses in 48.0% of cases and by dysplastic stenoses, aneurysms, and dissections in 66.1% of cases. RA imaging should be proposed to hypertensive patients with a cerebrovascular presentation. Cervical Artery imaging should be considered in patients with a renal presentation and bilateral RA lesions. Clinical Trial Registration— URL: www.Clinicaltrials.gov. Unique identifier: NCT02884141.
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Revisiting Fibromuscular Dysplasia: Rationale of the European Fibromuscular Dysplasia Initiative.
Hypertension (Dallas Tex. : 1979), 2016Co-Authors: Alexandre Persu, Pierrefrancois Plouin, Patricia Van Der Niepen, Emmanuel Touzé, Sofie Gevaert, E. Berra, Pamela Mace, Xavier JeunemaitreAbstract:Fibromuscular Dysplasia (FMD) has been defined as an idiopathic, segmental, nonatherosclerotic, and noninflammatory disease of the musculature of arterial walls, leading to stenosis of small- and medium-sized arteries.1,2 Furthermore, to confirm the diagnosis of FMD, arterial diseases of monogenic origin, inflammatory arterial diseases, and the use of arterial vasoconstrictors have to be excluded. Renal FMD may lead to renovascular hypertension, less frequently renal Artery dissection, renal infarction, and aneurysm rupture.1 Cervico-cephalic FMD can result in ischemic or hemorrhagic stroke, cervical Artery dissection, and may be also associated with intracerebral aneurysms and risk of subarachnoid hemorrhage.3 In some patients, the diagnosis of FMD can lead to invasive procedures, such as percutaneous angioplasty, reconstructive surgery, or intracranial aneurysm clipping. Thus, both the disease and its treatment can lead to significant morbidity and mortality.1 The French4–6 and the US7–10 registries have led to a reappraisal of the frequency, demographic characteristics, classification, pathophysiology, and management of FMD. The face of the disease is evolving from a rare disease of renal arteries accounting for a minority of cases of secondary hypertension in young women to a "systemic" vascular disease affecting renal and also cervico-cephalic, coronary, and iliac arteries1,11 (Table 1). In various cohorts, despite incomplete exploration, mostly driven by symptoms and clinical complaints, FMD of ≥2 vascular beds was consistently found in >30% of cases.1,7,12,13 The French ARCADIA (Assessment of Renal and Cervical Artery Dysplasia) registry, which required a standardized vascular work-up in all patients, will soon provide a more precise estimate of the frequency of diffuse FMD. Besides female sex and repeated mechanical trauma because of increased kidney mobility,14 recent works suggest a contribution of smoking6 in progression of the …
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Renal fibromuscular Dysplasia and cerebral aneurysm in a hypertensive patient with a familial history of cerebral vascular complications
Presse medicale (Paris France : 1983), 1997Co-Authors: Alexandre Persu, Yves Pirson, Christine Dubois, De Plaen JfAbstract:BACKGROUND The possibility of an association between two vascular anomalies, renal Artery Dysplasia and cerebral Artery aneurysm, merits recognition. CASE REPORT We report the case of a 63 year old woman who was found to have fibromuscular Dysplasia affecting the right renal Artery while being investigated for systemic hypertension. Given a family history of cerebrovascular accident occurring before the age of 50, a cerebral angiogram was performed which demonstrated a saccular aneurysm of the middle cerebral Artery measuring 6 mm in diameter. DISCUSSION The association of these two anomalies could result from a familial arterial fibromuscular Dysplasia. There are practical implications, notably the risk of aneurysm rupture and the role of hypertension.
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Fibromuscular Dysplasia of the renal Artery and cerebral aneurysm in a hypertensive patient with a familial history of stroke
Presse Medicale, 1997Co-Authors: Alexandre Persu, Yves Pirson, Christine Dubois, Jf. DeplaenAbstract:BACKGROUND: The possibility of an association between two vascular anomalies, renal Artery Dysplasia and cerebral Artery aneurysm, merits recognition. CASE REPORT: We report the case of a 63 year old woman who was found to have fibromuscular Dysplasia affecting the right renal Artery while being investigated for systemic hypertension. Given a family history of cerebrovascular accident occuring before the age of 50, a cerebral angiogram was performed which demonstrated a saccular aneurysm of the middle cerebral Artery measuring 6 mm in diameter. DISCUSSION: The association of these two anomalies could result from a familial arterial fibromuscular Dysplasia. There are practical implications, notably the risk of aneurysm rupture and the role of hypertension.
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Dysplasie fibromusculaire rénale et anévrisme cérébral chez une patiente hypertendue avec histoire familiale d'accidents vasculaires cérébraux.
Presse Medicale, 1997Co-Authors: Alexandre Persu, Yves Pirson, Christine Dubois, Jean-françois De PlaenAbstract:BACKGROUND: The possibility of an association between two vascular anomalies, renal Artery Dysplasia and cerebral Artery aneurysm, merits recognition. CASE REPORT: We report the case of a 63 year old woman who was found to have fibromuscular Dysplasia affecting the right renal Artery while being investigated for systemic hypertension. Given a family history of cerebrovascular accident occurring before the age of 50, a cerebral angiogram was performed which demonstrated a saccular aneurysm of the middle cerebral Artery measuring 6 mm in diameter. DISCUSSION: The association of these two anomalies could result from a familial arterial fibromuscular Dysplasia. There are practical implications, notably the risk of aneurysm rupture and the role of hypertension.
Yaohui Tang - One of the best experts on this subject based on the ideXlab platform.
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optimizing suture middle cerebral Artery occlusion model in c57bl 6 mice circumvents posterior communicating Artery Dysplasia
Journal of Neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
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Optimizing suture middle cerebral Artery occlusion model in C57BL/6 mice circumvents posterior communicating Artery Dysplasia.
Journal of neurotrauma, 2012Co-Authors: Falei Yuan, Yaohui Tang, Xiaojie Lin, Yongjing Guan, Tiqiao Xiao, Jun Chen, Zhijun Zhang, Guoyuan Yang, Yongting WangAbstract:Abstract The suture middle cerebral Artery occlusion (MCAO) model is used worldwide in both academia and industry. However, the variable occurrence of Dysplasia in posterior communicating arteries (PcomAs) induces high mortality and instability in permanent MCAO models, limiting the model's application to transient focal ischemia. In particular, high mortality in intraluminal suture MCAO models is associated with the Dysplasia of PcomAs in C57BL/6 mice. Optimization of silicone coating length is critical for reducing mortality and generating stable infarct in this model. The aim of our study is to reduce mortality and improve the reproducibility of the intraluminal suture MCAO model in C57BL/6 mice, which have high variation in PcomA Dysplasia. Adult male C57BL/6 mice (n=38) underwent MCAO using sutures with various diameters and silicone coating lengths. The occlusion of cerebral vessels was examined by synchrotron radiation live angiography. The morphology of PcomAs was examined under a microscope after...
