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Artery Intima

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Howard N. Hodis – 1st expert on this subject based on the ideXlab platform

  • Changes in carotid Artery Intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study
    Menopause, 2019
    Co-Authors: Virginia M Miller, Howard N. Hodis, Brian D. Lahr, Kent R. Bailey, Muthuvel Jayachandran

    Abstract:

    AbstractObjective:Little is known regarding the progression of preclinical atherosclerosis upon cessation of menopausal hormone therapy (MHT). This study evaluated changes in carotid Artery Intima-media thickness (CIMT) in a subgroup of participants during 4 years and 3 years after the Kronos Early

  • carotid Artery Intima media thickness and subclinical atherosclerosis in women with remote histories of preeclampsia results from a rochester epidemiology project based study and meta analysis
    Mayo Clinic Proceedings, 2017
    Co-Authors: Vesna D Garovic, Muthuvel Jayachandran, Brian D. Lahr, Kent R. Bailey, Natasa Milic, Tracey L Weissgerber, Michelle M Mielke, Wendy M White, Howard N. Hodis

    Abstract:

    Abstract Objective To measure carotid Artery Intima-media thickness (CIMT), a marker of subclinical atherosclerosis, in postmenopausal women with and without histories of preeclampsia and to synthesize these results with those from prior studies of CIMT performed 10 or more years after preeclamptic pregnancies. Patients and Methods Forty women (median age, 59 years) with histories of preeclampsia and 40 with histories of normotensive pregnancy (confirmed by medical record review) were selected from women who resided and gave birth in Olmsted County, Minnesota, between January 1, 1976, and December 31, 1982. The participants were identified and recruited in 2014-2015, and CIMT was measured by B-mode ultrasonography. Meta-analysis included CIMT studies that were performed 10 or more years after preeclamptic pregnancies and which were identified through PubMed, EMBASE, and Web of Science. Heterogeneity was assessed using the I 2 statistic. Standardized mean difference was used as a measure of effect size. Results Carotid Artery Intima-media thickness, expressed as a median (interquartile range), was greater in the preeclamptic than in the normotensive group (0.80 mm [0.75-0.85 mm] vs 0.73 mm [0.70-0.78]; P =.004); the odds of having CIMT higher than threshold (0.77 mm) was statistically significant after adjusting for confounding factors (odds ratio, 3.17; 95% CI, 1.10-9.14). A meta-analysis of 10 studies conducted 10 or more years post partum included 813 women with and 2874 without histories of preeclampsia. Carotid Artery Intima-media thickness was greater among women with histories of preeclampsia, with a standardized mean difference of 0.18 and 95% CI of 0.05 to 0.30 mm ( P =.004). Conclusion Among women with histories of preeclampsia, CIMT may identify those with subclinical atherosclerosis, thus offering an opportunity for early intervention.

  • pharmacogenomics of estrogens on changes in carotid Artery Intima medial thickness and coronary arterial calcification kronos early estrogen prevention study
    Physiological Genomics, 2016
    Co-Authors: Virginia M Miller, Howard N. Hodis, Gregory D Jenkins, Joanna M Biernacka, John A Heit, Gordon S Huggins, Matthew J Budoff, Rogerio A Lobo, Hugh S Taylor, Joann E Manson

    Abstract:

    Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid Artery Intima-medial thickness (CIMT) and c…

Joann E Manson – 2nd expert on this subject based on the ideXlab platform

  • pharmacogenomics of estrogens on changes in carotid Artery Intima medial thickness and coronary arterial calcification kronos early estrogen prevention study
    Physiological Genomics, 2016
    Co-Authors: Virginia M Miller, Howard N. Hodis, Gregory D Jenkins, Joanna M Biernacka, John A Heit, Gordon S Huggins, Matthew J Budoff, Rogerio A Lobo, Hugh S Taylor, Joann E Manson

    Abstract:

    Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid Artery Intima-medial thickness (CIMT) and c…

Barry I Freedman – 3rd expert on this subject based on the ideXlab platform

  • heritability of carotid Artery Intima medial thickness in type 2 diabetes
    Stroke, 2002
    Co-Authors: Leslie A Lange, Donald W Bowden, Carl D Langefeld, Lynne E Wagenknecht, Jeffrey J Carr, Stephen S Rich, Ward A Riley, Barry I Freedman

    Abstract:

    Background and Purpose— Carotid Artery Intima-medial thickness (IMT), a marker of subclinical atherosclerosis, is a strong predictor of subsequent cardiovascular morbidity. The role of genetic factors in thickening of the carotid wall remains largely unknown. We hypothesize that in families with multiple members having diabetes, carotid IMT is likely to be associated with both inherited and environmental factors. Methods— To determine the extent of the familial aggregation of carotid IMT in the presence of type 2 diabetes, we studied 252 individuals with type 2 diabetes (mean age 60.6 years) from 122 families. Common carotid Artery IMT was measured by high-resolution B-mode ultrasonography. Other measured factors included lipid levels, body mass index, fasting glucose, hemoglobin A1c, albumin/creatinine ratio, and self-reported medical history. Heritability estimates were obtained by using variance component methodology, as implemented in the SOLAR software package. Tests for association between carotid I…