Artery Intima

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Howard N. Hodis - One of the best experts on this subject based on the ideXlab platform.

  • Changes in carotid Artery Intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study
    Menopause, 2019
    Co-Authors: Virginia M Miller, Howard N. Hodis, Brian D. Lahr, Kent R. Bailey, Muthuvel Jayachandran
    Abstract:

    AbstractObjective:Little is known regarding the progression of preclinical atherosclerosis upon cessation of menopausal hormone therapy (MHT). This study evaluated changes in carotid Artery Intima-media thickness (CIMT) in a subgroup of participants during 4 years and 3 years after the Kronos Early

  • carotid Artery Intima media thickness and subclinical atherosclerosis in women with remote histories of preeclampsia results from a rochester epidemiology project based study and meta analysis
    Mayo Clinic Proceedings, 2017
    Co-Authors: Vesna D Garovic, Brian D. Lahr, Kent R. Bailey, Muthuvel Jayachandran, Natasa Milic, Tracey L Weissgerber, Michelle M Mielke, Wendy M White, Howard N. Hodis
    Abstract:

    Abstract Objective To measure carotid Artery Intima-media thickness (CIMT), a marker of subclinical atherosclerosis, in postmenopausal women with and without histories of preeclampsia and to synthesize these results with those from prior studies of CIMT performed 10 or more years after preeclamptic pregnancies. Patients and Methods Forty women (median age, 59 years) with histories of preeclampsia and 40 with histories of normotensive pregnancy (confirmed by medical record review) were selected from women who resided and gave birth in Olmsted County, Minnesota, between January 1, 1976, and December 31, 1982. The participants were identified and recruited in 2014-2015, and CIMT was measured by B-mode ultrasonography. Meta-analysis included CIMT studies that were performed 10 or more years after preeclamptic pregnancies and which were identified through PubMed, EMBASE, and Web of Science. Heterogeneity was assessed using the I 2 statistic. Standardized mean difference was used as a measure of effect size. Results Carotid Artery Intima-media thickness, expressed as a median (interquartile range), was greater in the preeclamptic than in the normotensive group (0.80 mm [0.75-0.85 mm] vs 0.73 mm [0.70-0.78]; P =.004); the odds of having CIMT higher than threshold (0.77 mm) was statistically significant after adjusting for confounding factors (odds ratio, 3.17; 95% CI, 1.10-9.14). A meta-analysis of 10 studies conducted 10 or more years post partum included 813 women with and 2874 without histories of preeclampsia. Carotid Artery Intima-media thickness was greater among women with histories of preeclampsia, with a standardized mean difference of 0.18 and 95% CI of 0.05 to 0.30 mm ( P =.004). Conclusion Among women with histories of preeclampsia, CIMT may identify those with subclinical atherosclerosis, thus offering an opportunity for early intervention.

  • pharmacogenomics of estrogens on changes in carotid Artery Intima medial thickness and coronary arterial calcification kronos early estrogen prevention study
    Physiological Genomics, 2016
    Co-Authors: Virginia M Miller, Howard N. Hodis, Gregory D Jenkins, Joanna M Biernacka, John A Heit, Gordon S Huggins, Matthew J Budoff, Rogerio A Lobo, Hugh S Taylor, Joann E Manson
    Abstract:

    Prior to the initiation of menopausal hormone treatment (MHT), genetic variations in the innate immunity pathway were found to be associated with carotid Artery Intima-medial thickness (CIMT) and c...

  • Birth weight and carotid Artery Intima-media thickness.
    The Journal of Pediatrics, 2012
    Co-Authors: Julia Dratva, Carrie V. Breton, Wendy J. Mack, Howard N. Hodis, Muhammad T. Salam, Elisabeth Zemp, Frank D. Gilliland, Nino Kuenzli, Edward L. Avol
    Abstract:

    Objectives To determine the association between birth weight and carotid Artery Intima-media thickness (CIMT), a measure of atherogenesis, in a population of 11-year-old children. Study design CIMT measured by high-resolution ultrasound, and birth registry data were available for 670 children of the Southern California Children's Health Study. Multivariate regression analyses were performed to investigate the association between birth weight and CIMT, with adjustment for child's health status and lifestyle, pregnancy information, and parental health. Results Mean CIMT was 0.57 mm (SD 0.04). We found a nonlinear association between birth weight and CIMT, with an increase in CIMT of 0.014 mm in the fifth ( P value .01) compared with the third birth weight quintile. These associations were robust in subsample analyses in children considered normal-weight by gestational age or in term-born children. No significant association with CIMT was found for the lowest quintile. Conclusions Greater birth weight was significantly associated with increased CIMT at age 11 years. No evidence for an impact of lower birth weight was found. The predictive value of childhood CIMT on future cardiovascular outcomes is largely unknown, but strong associations between childhood cardiovascular disease risk factors and adult vascular disease suggest that increased CIMT in childhood may be clinically important.

  • childhood air pollutant exposure and carotid Artery Intima media thickness in young adults
    Circulation, 2012
    Co-Authors: Carrie V. Breton, Xinhui Wang, Wendy J. Mack, Kiros Berhane, Milena Lopez, Talat Islam, Mei Feng, Fred Lurmann, Rob Mcconnell, Howard N. Hodis
    Abstract:

    Background—Exposure to ambient air pollutants increases risk for cardiovascular health outcomes in adults. The contribution of childhood air pollutant exposure to cardiovascular health has not been thoroughly evaluated. Methods and Results—The Testing Responses on Youth study consists of 861 college students recruited from the University of Southern California in 2007 to 2009. Participants attended 1 study visit during which blood pressure, heart rate, and carotid Artery Intima-media thickness (CIMT) were assessed. Self-administered questionnaires collected information about health and sociodemographic characteristics, and a 12-hour fasting blood sample was drawn for lipid and biomarker analyses. Residential addresses were geocoded and used to assign cumulative air pollutant exposure estimates based on data derived from the U.S. Environmental Protection Agency's Air Quality System database. The associations between CIMT and air pollutants were assessed using linear regression analysis. Mean CIMT was 603 μ...

Joann E Manson - One of the best experts on this subject based on the ideXlab platform.

Barry I Freedman - One of the best experts on this subject based on the ideXlab platform.

  • heritability of carotid Artery Intima medial thickness in type 2 diabetes
    Stroke, 2002
    Co-Authors: Leslie A Lange, Donald W Bowden, Carl D Langefeld, Lynne E Wagenknecht, Jeffrey J Carr, Stephen S Rich, Ward A Riley, Barry I Freedman
    Abstract:

    Background and Purpose— Carotid Artery Intima-medial thickness (IMT), a marker of subclinical atherosclerosis, is a strong predictor of subsequent cardiovascular morbidity. The role of genetic factors in thickening of the carotid wall remains largely unknown. We hypothesize that in families with multiple members having diabetes, carotid IMT is likely to be associated with both inherited and environmental factors. Methods— To determine the extent of the familial aggregation of carotid IMT in the presence of type 2 diabetes, we studied 252 individuals with type 2 diabetes (mean age 60.6 years) from 122 families. Common carotid Artery IMT was measured by high-resolution B-mode ultrasonography. Other measured factors included lipid levels, body mass index, fasting glucose, hemoglobin A1c, albumin/creatinine ratio, and self-reported medical history. Heritability estimates were obtained by using variance component methodology, as implemented in the SOLAR software package. Tests for association between carotid I...

Frank B Hu - One of the best experts on this subject based on the ideXlab platform.

  • carotid Artery Intima media thickness carotid plaque and coronary heart disease and stroke in chinese
    PLOS ONE, 2008
    Co-Authors: Kuoliong Chien, Tachen Su, Jiannshing Jeng, Weitien Chang, Mingfong Chen, Frank B Hu
    Abstract:

    Background Our aim was to prospectively investigate the association between carotid Artery Intima-media thickness (IMT) as well as carotid plaque and incidence of coronary heart disease (CHD) and stroke in Chinese, among whom data are limited. Methods and Findings We conducted a community-based cohort study composed of 2190 participants free of cardiovascular disease at baseline in one community. During a median 10.5-year follow up, we documented 68 new cases of coronary heart disease and 94 cases of stroke. The multivariate relative risks (RRs) associated with a change of 1 standard deviation of maximal common carotid IMT were 1.38 (95% confidence interval [CI], 1.12–1.70) for CHD and 1.47 (95% CI, 1.28–1.69) for stroke. The corresponding RRs with internal carotid IMT were 1.47 (95% CI, 1.21–1.79) for CHD and 1.52 (95% CI, 1.31–1.76) for stroke. Carotid plaque measured by the degree of diameter stenosis was also significantly associated with increased risk of CHD (p for trend<0.0001) and stroke (p for trend<0.0001). However, these associations were largely attenuated when adjusting for IMT measurements. Conclusions This prospective study indicates a significant association between carotid IMT and incidence of CHD and stroke in Chinese adults. These measurements may be useful for cardiovascular risk assessment and stratification in Chinese.

Virginia M Miller - One of the best experts on this subject based on the ideXlab platform.

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