Artery Lesion

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Yoshinobu Onuma - One of the best experts on this subject based on the ideXlab platform.

Ricardo A Costa - One of the best experts on this subject based on the ideXlab platform.

Gurpreet Singh Wander - One of the best experts on this subject based on the ideXlab platform.

Masahiko Shibuya - One of the best experts on this subject based on the ideXlab platform.

  • effect of bare metal nitinol stent implantation and paclitaxel eluting nitinol stent implantation on vascular response in the superficial femoral Artery Lesion assessed on intravascular ultrasound
    Circulation, 2014
    Co-Authors: Kojiro Miki, Kenichi Fujii, Daizo Kawasaki, Masashi Fukunaga, Machiko Nishimura, Tetsuo Horimatsu, Ten Saita, Hiroto Tamaru, Takahiro Imanaka, Masahiko Shibuya
    Abstract:

    Background: Although previous intravascular ultrasound (IVUS) studies reported that the drug-eluting stent (DES) has successfully decreased in-stent restenosis (ISR) by inhibiting neointimal hyperplasia (NIH) in the coronary Artery Lesion, no IVUS data for vascular response after DES implantation in the superficial femoral Artery (SFA) have been published. Methods and Results: We retrospectively analyzed 38 de novo SFA Lesions from 32 patients who underwent endovascular therapy (EVT) with self-expanding bare-metal nitinol stent (25 Lesions; BMS group) or self-expanding paclitaxel-eluting nitinol stents (13 Lesions; PES group). At 6 months after EVT, follow-up IVUS was done to evaluate NIH. Serial IVUS volumetric analysis was done after stent deployment and at follow-up. Mean stent, lumen and neointimal areas were calculated as the volume divided by the stent length. The primary endpoint of this study was mean late lumen loss at 6-month follow-up. The mean follow-up period was 189±39 days. Mean neointimal area was smaller in the PES group compared to the BMS group (3.3±1.0mm2 vs. 10.2±4.1mm2, P<0.001). Mean late lumen loss was significantly lower in the PES group compared to the BMS group (−2.3±3.7mm2 vs. 2.1±4.7mm2, P<0.05). Conclusions: EVT with DES in SFA Lesions might decrease NIH associated with ISR in short-term follow-up.  (Circ J 2014; 78: 1451–1458)

Marie-lucebochaton-piallat - One of the best experts on this subject based on the ideXlab platform.

  • Phenotypic Modulation of Intima and Media Smooth Muscle Cells in Fatal Cases of Coronary Artery Lesion
    Arteriosclerosis Thrombosis and Vascular Biology, 2006
    Co-Authors: Hiroyukihao, Giuliogabbiani, Edoardocamenzind, Marcbacchetta, Renuvirmani, Marie-lucebochaton-piallat
    Abstract:

    Objectives— Characterize the phenotypic features of media and intima coronary Artery smooth muscle cells (SMCs) in mildly stenotic plaques, erosions, stable plaques, and in-stent restenosis. Methods and Results— Expression of α-smooth muscle actin (α-SMA), smooth muscle myosin heavy chains (SMMHCs), and smoothelin was investigated by immunohistochemistry followed by morphometric quantification. The cross-sectional area and the expression of cytoskeletal proteins in the media were lower in restenotic Lesions and, to a lesser extent, in stable plaques compared with mildly stenotic plaques and erosions. An important expression of α-SMA was detected in the intima of the different Lesions; moreover, α-SMA staining was significantly larger in erosions compared with all other conditions. In the same location, a striking decrease of SMMHCs and a disappearance of smoothelin were observed in all situations. Conclusions— Medial atrophy is prevalent in restenotic Lesions and stable plaques compared with mildly stenot...