Scan Science and Technology
Contact Leading Edge Experts & Companies
The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Masatoshi Makuuchi – 1st expert on this subject based on the ideXlab platform
prevention of hepatic Artery Thrombosis in pediatric liver transplantationTransplantation, 1995Co-Authors: Yasuhiko Hashikura, Seiji Kawasaki, Nobuo Okumura, S Ishikawa, Hidetoshi Matsunami, Toshihiko Ikegami, Yuichi Nakazawa, Masatoshi MakuuchiAbstract:
Hepatic Artery Thrombosis after orthotopic liver transplantation is a serious complication, especially in children. We report our experience with intensive anticoagulant therapy during and after living-related liver transplantation in pediatric recipients. Twenty-four patients between 5 months and 15 years of age were studied. The mean diameter of the anastomosed hepatic arteries was 2.7 mm. The anticoagulant therapy consisted of low-molecular-weight heparin, antithrombin III concentrates, prostaglandin E 1 , fresh frozen plasma, and a protease inhibitor. The profiles of the coagulation and fibrinolytic systems were monitored by measuring several parameters, including plasma levels of thrombin-antithrombin III complex, antithrombin III, plasmin-α2 plasmin inhibitor complex, fibrin degradation product D-dimer, tissue type-plasminogen activator, and plasminogen activator inhibitor-1. Acceleration of the coagulation system and delayed recovery of the fibrinolytic system were observed during the early postoperative days. The plasma level of antithrombin III activity was maintained within the normal range by the administration of antithrombin III concentrates. None of the recipients developed hepatic Artery Thrombosis. Children have been reported to be at a greater risk of developing hepatic Artery Thrombosis than adults due to the small diameters of their hepatic arteries and the postoperative hypercoagulable state. We believe that the intensive anticoagulation therapy described in this study, the main concept of which is the early correction of imbalance between the coagulant and anticoagulant systems, could become a model for the prevention of hepatic Artery Thrombosis in pediatric liver transplantation patients.
Cosme Manzarbeitia – 2nd expert on this subject based on the ideXlab platform
sonographic diagnosis and outcome of hepatic Artery Thrombosis after orthotopic liver transplantation in adultsAmerican Journal of Roentgenology, 2007Co-Authors: Mindy M Horrow, Beth M Blumenthal, David J Reich, Cosme ManzarbeitiaAbstract:
OBJECTIVE. The objective of our study was to determine the timing and frequency of symptomatic hepatic Artery Thrombosis in an adult orthotopic liver transplant population, the sensitivity of Doppler sonography for this diagnosis, and the clinical and sonography outcomes in this population.MATERIALS AND METHODS. The subjects included all adult recipients with orthotopic liver transplants during a 10.5-year period. A retrospective review of all cases of hepatic Artery Thrombosis detected on angiography or at surgery was correlated with sonography findings at diagnosis. Clinical and sonography outcomes were recorded. Patients were divided into early (< 1 week) and late hepatic Artery Thrombosis groups. Hepatic Artery Thrombosis was considered primary or secondary due to treatment of other hepatic Artery complications.RESULTS. Of 522 transplants, 25 (4.8%) developed hepatic Artery Thrombosis that was primary in 18 (3.5%), with five early (1.0%) and 13 late (2.5%), and secondary in seven (1.3%). Sensitivities…
Li Yanping – 3rd expert on this subject based on the ideXlab platform
middle cerebral Artery Thrombosis after ivf and ovarian hyperstimulation a case reportFertility and Sterility, 2011Co-Authors: Zhao Jing, Li YanpingAbstract:
Objective To report a rare case of left middle cerebral Artery Thrombosis in a patient after controlled ovarian hyperstimulation and IVF. Design Case report. Setting University-affiliated teaching hospital. Patient(s) A 30-year-old woman who had undergone in vitro fertilization and subsequently developed left middle cerebral Artery Thrombosis. Intervention(s) Ovulation induction with gonadotropins, IVF-ET, sodium ozagrel injection, and mannitol and albumin administration. Main Outcome Measure(s) Outcome of treatment. Result(s) The patient survived with some neurologic sequelae. Conclusion(s) Prevention of ovarian hyperstimulation syndrome is key to reducing incidence of Thrombosis. Be aware of any neurologic symptoms after IVF-ET. Immediate and correct therapy should be given after Thrombosis is suspected.