The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Jeffrey W. Kysar - One of the best experts on this subject based on the ideXlab platform.
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small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and Surfaces B: Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p < 0.05 for all saline-based experiments), but the same association was not found with P407. Rather, for a P407 reservoir, only a large perforation increased permeance (p < 0.001), while multiple small perforations did not (p = 0.749). These results confirm that for drug dissolved in saline, multiple small perforations can effectively enhance diffusion. However, for drug dissolved in P407, larger perforations are necessary.
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Small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and surfaces. B Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p
Anil K. Lalwani - One of the best experts on this subject based on the ideXlab platform.
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small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and Surfaces B: Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p < 0.05 for all saline-based experiments), but the same association was not found with P407. Rather, for a P407 reservoir, only a large perforation increased permeance (p < 0.001), while multiple small perforations did not (p = 0.749). These results confirm that for drug dissolved in saline, multiple small perforations can effectively enhance diffusion. However, for drug dissolved in P407, larger perforations are necessary.
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Small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and surfaces. B Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p
A. Santimetaneedol - One of the best experts on this subject based on the ideXlab platform.
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small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and Surfaces B: Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p < 0.05 for all saline-based experiments), but the same association was not found with P407. Rather, for a P407 reservoir, only a large perforation increased permeance (p < 0.001), while multiple small perforations did not (p = 0.749). These results confirm that for drug dissolved in saline, multiple small perforations can effectively enhance diffusion. However, for drug dissolved in P407, larger perforations are necessary.
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Small molecule delivery across a perforated Artificial Membrane by thermoreversible hydrogel poloxamer 407
Colloids and surfaces. B Biointerfaces, 2019Co-Authors: A. Santimetaneedol, Anil K. Lalwani, Z. Wang, D.n. Arteaga, Aykut Aksit, C. Prevoteau, H. Chiang, Dimitrios Fafalis, Jeffrey W. KysarAbstract:Microperforations in the round window Membrane have been suggested for enhancing the rate and reliability of drug delivery into the cochlea. Intratympanic injection, the most common delivery method, involves injecting therapy into the middle ear to establish a reservoir from which drug diffuses across the round window Membrane into the cochlea. This process is highly variable because (i) the reservoir, if liquid, can lose contact with the Membrane and (ii) diffusion across the Membrane is intrinsically variable even with a stable reservoir. To address these respective sources of variability, we compared the thermoreversible hydrogel poloxamer 407 (P407) to saline as a drug carrier and studied the effect of Membrane microperforations on drug diffusion rate. We used Rhodamine B as a drug proxy to measure permeance across an Artificial Membrane in a horizontal diffusion cell. We found that permeance of Rhodamine B from a saline reservoir was an order of magnitude higher than that from a P407 reservoir across unperforated Membranes. Moreover, permeance increased with total perforation cross-sectional area regardless of number of perforations (p
Guillermo Reglero - One of the best experts on this subject based on the ideXlab platform.
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in vitro permeability of saponins and sapogenins from seed extracts by the parallel Artificial Membrane permeability assay effect of in vitro gastrointestinal digestion
Journal of Agricultural and Food Chemistry, 2020Co-Authors: Joaquin Navarro Del Hierro, Vieri Piazzini, Guillermo Reglero, Diana Martin, Maria Camilla BergonziAbstract:The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well as dioscin and diosgenin, was evaluated by the parallel Artificial Membrane permeability assay (PAMPA). The e...
Joaquin Navarro Del Hierro - One of the best experts on this subject based on the ideXlab platform.
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in vitro permeability of saponins and sapogenins from seed extracts by the parallel Artificial Membrane permeability assay effect of in vitro gastrointestinal digestion
Journal of Agricultural and Food Chemistry, 2020Co-Authors: Joaquin Navarro Del Hierro, Vieri Piazzini, Guillermo Reglero, Diana Martin, Maria Camilla BergonziAbstract:The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well as dioscin and diosgenin, was evaluated by the parallel Artificial Membrane permeability assay (PAMPA). The e...
