The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Muredach P. Reilly - One of the best experts on this subject based on the ideXlab platform.
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Ascending and Descending thoracic aorta calcification in type 2 diabetes mellitus.
Journal of cardiovascular computed tomography, 2015Co-Authors: Timothy W. Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Victor A. Ferrari, Saurabh Jha, Scott Lilly, Luis H. Eraso, Muredach P. ReillyAbstract:Abstract Background Calcification of the thoracic aorta is a risk factor for cardiovascular disease and peripheral arterial disease but has not been well studied in diabetics. In addition, many studies consider aortic calcium as a single anatomic entity, whereas calcification of the Ascending and Descending portions of the thoracic aorta may represent separate phenotypes. We sought to characterize the prevalence of Ascending and Descending aortic calcium among diabetics and to assess their associations with cardiovascular risk factors, coronary artery calcium, and peripheral arterial disease. Methods Within the Penn Diabetes Heart Study, a cross-sectional study of subjects with type 2 diabetes mellitus but without coronary or renal disease, we quantified Agatston scores of the Ascending and Descending thoracic aorta in 1739 subjects (63% male, 61% Caucasian). Multivariate logistic and Tobit regressions were used to assess associations with cardiovascular risk factors, coronary calcium, and peripheral arterial disease. Results Of all subjects, 54% had thoracic aortic calcium; of these, 37% had calcium solely in the Ascending thoracic aorta and 20% solely in the Descending thoracic aorta. In multivariate regression, age, Caucasian race, systolic blood pressure, low-density lipoprotein cholesterol, smoking, and diabetes duration were independently associated with calcium of both the Ascending and Descending thoracic aorta ( P Conclusion Ascending and Descending thoracic aortic calcium have similar associations with traditional cardiovascular risk factors in diabetics and are independently associated with coronary artery calcium. Only calcium in the Descending aorta is associated with peripheral arterial disease. Delineation of both phenotypes may provide information about the individualized vascular disease and risk profile of patients with type 2 diabetes mellitus.
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CALCIFICATION OF THE Ascending and Descending THORACIC AORTA IDENTIFIES TWO DISTINCT PHENOTYPES IN TYPE 2 DIABETES
Journal of the American College of Cardiology, 2012Co-Authors: Timothy Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Saurabh Jha, Scott Lilly, Luis H. Eraso, Victor Ferrari, Muredach P. ReillyAbstract:The evidence regarding thoracic aortic calcification (TAC) as a potential independent risk factor for cardiovascular disease (CVD) and mortality is mixed. However, many studies consider TAC as a single anatomic entity, when in fact the Ascending and Descending aorta are subject to different
Suraj P. Rasania - One of the best experts on this subject based on the ideXlab platform.
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Ascending and Descending thoracic aorta calcification in type 2 diabetes mellitus.
Journal of cardiovascular computed tomography, 2015Co-Authors: Timothy W. Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Victor A. Ferrari, Saurabh Jha, Scott Lilly, Luis H. Eraso, Muredach P. ReillyAbstract:Abstract Background Calcification of the thoracic aorta is a risk factor for cardiovascular disease and peripheral arterial disease but has not been well studied in diabetics. In addition, many studies consider aortic calcium as a single anatomic entity, whereas calcification of the Ascending and Descending portions of the thoracic aorta may represent separate phenotypes. We sought to characterize the prevalence of Ascending and Descending aortic calcium among diabetics and to assess their associations with cardiovascular risk factors, coronary artery calcium, and peripheral arterial disease. Methods Within the Penn Diabetes Heart Study, a cross-sectional study of subjects with type 2 diabetes mellitus but without coronary or renal disease, we quantified Agatston scores of the Ascending and Descending thoracic aorta in 1739 subjects (63% male, 61% Caucasian). Multivariate logistic and Tobit regressions were used to assess associations with cardiovascular risk factors, coronary calcium, and peripheral arterial disease. Results Of all subjects, 54% had thoracic aortic calcium; of these, 37% had calcium solely in the Ascending thoracic aorta and 20% solely in the Descending thoracic aorta. In multivariate regression, age, Caucasian race, systolic blood pressure, low-density lipoprotein cholesterol, smoking, and diabetes duration were independently associated with calcium of both the Ascending and Descending thoracic aorta ( P Conclusion Ascending and Descending thoracic aortic calcium have similar associations with traditional cardiovascular risk factors in diabetics and are independently associated with coronary artery calcium. Only calcium in the Descending aorta is associated with peripheral arterial disease. Delineation of both phenotypes may provide information about the individualized vascular disease and risk profile of patients with type 2 diabetes mellitus.
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CALCIFICATION OF THE Ascending and Descending THORACIC AORTA IDENTIFIES TWO DISTINCT PHENOTYPES IN TYPE 2 DIABETES
Journal of the American College of Cardiology, 2012Co-Authors: Timothy Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Saurabh Jha, Scott Lilly, Luis H. Eraso, Victor Ferrari, Muredach P. ReillyAbstract:The evidence regarding thoracic aortic calcification (TAC) as a potential independent risk factor for cardiovascular disease (CVD) and mortality is mixed. However, many studies consider TAC as a single anatomic entity, when in fact the Ascending and Descending aorta are subject to different
Hashmi Rafeek - One of the best experts on this subject based on the ideXlab platform.
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Ascending and Descending thoracic aorta calcification in type 2 diabetes mellitus.
Journal of cardiovascular computed tomography, 2015Co-Authors: Timothy W. Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Victor A. Ferrari, Saurabh Jha, Scott Lilly, Luis H. Eraso, Muredach P. ReillyAbstract:Abstract Background Calcification of the thoracic aorta is a risk factor for cardiovascular disease and peripheral arterial disease but has not been well studied in diabetics. In addition, many studies consider aortic calcium as a single anatomic entity, whereas calcification of the Ascending and Descending portions of the thoracic aorta may represent separate phenotypes. We sought to characterize the prevalence of Ascending and Descending aortic calcium among diabetics and to assess their associations with cardiovascular risk factors, coronary artery calcium, and peripheral arterial disease. Methods Within the Penn Diabetes Heart Study, a cross-sectional study of subjects with type 2 diabetes mellitus but without coronary or renal disease, we quantified Agatston scores of the Ascending and Descending thoracic aorta in 1739 subjects (63% male, 61% Caucasian). Multivariate logistic and Tobit regressions were used to assess associations with cardiovascular risk factors, coronary calcium, and peripheral arterial disease. Results Of all subjects, 54% had thoracic aortic calcium; of these, 37% had calcium solely in the Ascending thoracic aorta and 20% solely in the Descending thoracic aorta. In multivariate regression, age, Caucasian race, systolic blood pressure, low-density lipoprotein cholesterol, smoking, and diabetes duration were independently associated with calcium of both the Ascending and Descending thoracic aorta ( P Conclusion Ascending and Descending thoracic aortic calcium have similar associations with traditional cardiovascular risk factors in diabetics and are independently associated with coronary artery calcium. Only calcium in the Descending aorta is associated with peripheral arterial disease. Delineation of both phenotypes may provide information about the individualized vascular disease and risk profile of patients with type 2 diabetes mellitus.
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CALCIFICATION OF THE Ascending and Descending THORACIC AORTA IDENTIFIES TWO DISTINCT PHENOTYPES IN TYPE 2 DIABETES
Journal of the American College of Cardiology, 2012Co-Authors: Timothy Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Saurabh Jha, Scott Lilly, Luis H. Eraso, Victor Ferrari, Muredach P. ReillyAbstract:The evidence regarding thoracic aortic calcification (TAC) as a potential independent risk factor for cardiovascular disease (CVD) and mortality is mixed. However, many studies consider TAC as a single anatomic entity, when in fact the Ascending and Descending aorta are subject to different
Claire K. Mulvey - One of the best experts on this subject based on the ideXlab platform.
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Ascending and Descending thoracic aorta calcification in type 2 diabetes mellitus.
Journal of cardiovascular computed tomography, 2015Co-Authors: Timothy W. Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Victor A. Ferrari, Saurabh Jha, Scott Lilly, Luis H. Eraso, Muredach P. ReillyAbstract:Abstract Background Calcification of the thoracic aorta is a risk factor for cardiovascular disease and peripheral arterial disease but has not been well studied in diabetics. In addition, many studies consider aortic calcium as a single anatomic entity, whereas calcification of the Ascending and Descending portions of the thoracic aorta may represent separate phenotypes. We sought to characterize the prevalence of Ascending and Descending aortic calcium among diabetics and to assess their associations with cardiovascular risk factors, coronary artery calcium, and peripheral arterial disease. Methods Within the Penn Diabetes Heart Study, a cross-sectional study of subjects with type 2 diabetes mellitus but without coronary or renal disease, we quantified Agatston scores of the Ascending and Descending thoracic aorta in 1739 subjects (63% male, 61% Caucasian). Multivariate logistic and Tobit regressions were used to assess associations with cardiovascular risk factors, coronary calcium, and peripheral arterial disease. Results Of all subjects, 54% had thoracic aortic calcium; of these, 37% had calcium solely in the Ascending thoracic aorta and 20% solely in the Descending thoracic aorta. In multivariate regression, age, Caucasian race, systolic blood pressure, low-density lipoprotein cholesterol, smoking, and diabetes duration were independently associated with calcium of both the Ascending and Descending thoracic aorta ( P Conclusion Ascending and Descending thoracic aortic calcium have similar associations with traditional cardiovascular risk factors in diabetics and are independently associated with coronary artery calcium. Only calcium in the Descending aorta is associated with peripheral arterial disease. Delineation of both phenotypes may provide information about the individualized vascular disease and risk profile of patients with type 2 diabetes mellitus.
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CALCIFICATION OF THE Ascending and Descending THORACIC AORTA IDENTIFIES TWO DISTINCT PHENOTYPES IN TYPE 2 DIABETES
Journal of the American College of Cardiology, 2012Co-Authors: Timothy Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Saurabh Jha, Scott Lilly, Luis H. Eraso, Victor Ferrari, Muredach P. ReillyAbstract:The evidence regarding thoracic aortic calcification (TAC) as a potential independent risk factor for cardiovascular disease (CVD) and mortality is mixed. However, many studies consider TAC as a single anatomic entity, when in fact the Ascending and Descending aorta are subject to different
Karen Terembula - One of the best experts on this subject based on the ideXlab platform.
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Ascending and Descending thoracic aorta calcification in type 2 diabetes mellitus.
Journal of cardiovascular computed tomography, 2015Co-Authors: Timothy W. Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Victor A. Ferrari, Saurabh Jha, Scott Lilly, Luis H. Eraso, Muredach P. ReillyAbstract:Abstract Background Calcification of the thoracic aorta is a risk factor for cardiovascular disease and peripheral arterial disease but has not been well studied in diabetics. In addition, many studies consider aortic calcium as a single anatomic entity, whereas calcification of the Ascending and Descending portions of the thoracic aorta may represent separate phenotypes. We sought to characterize the prevalence of Ascending and Descending aortic calcium among diabetics and to assess their associations with cardiovascular risk factors, coronary artery calcium, and peripheral arterial disease. Methods Within the Penn Diabetes Heart Study, a cross-sectional study of subjects with type 2 diabetes mellitus but without coronary or renal disease, we quantified Agatston scores of the Ascending and Descending thoracic aorta in 1739 subjects (63% male, 61% Caucasian). Multivariate logistic and Tobit regressions were used to assess associations with cardiovascular risk factors, coronary calcium, and peripheral arterial disease. Results Of all subjects, 54% had thoracic aortic calcium; of these, 37% had calcium solely in the Ascending thoracic aorta and 20% solely in the Descending thoracic aorta. In multivariate regression, age, Caucasian race, systolic blood pressure, low-density lipoprotein cholesterol, smoking, and diabetes duration were independently associated with calcium of both the Ascending and Descending thoracic aorta ( P Conclusion Ascending and Descending thoracic aortic calcium have similar associations with traditional cardiovascular risk factors in diabetics and are independently associated with coronary artery calcium. Only calcium in the Descending aorta is associated with peripheral arterial disease. Delineation of both phenotypes may provide information about the individualized vascular disease and risk profile of patients with type 2 diabetes mellitus.
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CALCIFICATION OF THE Ascending and Descending THORACIC AORTA IDENTIFIES TWO DISTINCT PHENOTYPES IN TYPE 2 DIABETES
Journal of the American College of Cardiology, 2012Co-Authors: Timothy Churchill, Suraj P. Rasania, Hashmi Rafeek, Claire K. Mulvey, Karen Terembula, Saurabh Jha, Scott Lilly, Luis H. Eraso, Victor Ferrari, Muredach P. ReillyAbstract:The evidence regarding thoracic aortic calcification (TAC) as a potential independent risk factor for cardiovascular disease (CVD) and mortality is mixed. However, many studies consider TAC as a single anatomic entity, when in fact the Ascending and Descending aorta are subject to different
