Ascorbic Acid

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Henrik J. Andersen - One of the best experts on this subject based on the ideXlab platform.

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of Agricultural and Food Chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin−Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals. Keywords: Ascorbic Acid; Ascorbic Acid 6-palmitate; oxidation; egg yolk; ph...

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of agricultural and food chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin-Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals.

Jacob Holm Nielsen - One of the best experts on this subject based on the ideXlab platform.

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of Agricultural and Food Chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin−Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals. Keywords: Ascorbic Acid; Ascorbic Acid 6-palmitate; oxidation; egg yolk; ph...

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of agricultural and food chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin-Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals.

Fumihiko Horio - One of the best experts on this subject based on the ideXlab platform.

  • Changes in catecholamine metabolism by Ascorbic Acid deficiency in spontaneously hypertensive rats unable to synthesize Ascorbic Acid
    Life sciences, 2003
    Co-Authors: Kaori Kawai, Susumu Makino, Hiroyuki Ito, Hiroko Kubota, Kumiko Takemori, Fumihiko Horio
    Abstract:

    We have previously reported the establishment of a novel rat strain, SHR-od, with both spontaneous hypertension and a defect of Ascorbic Acid biosynthesis. Blood pressure in mature SHR-od fed an Ascorbic Acid-supplemented diet is over 190-200 mmHg, while it decreased to around 120 mmHg at 4-5 weeks after the cessation of Ascorbic Acid supplementation. With regard to possible mechanisms of blood pressure lowering, we focused on catecholamine synthesis in adrenal glands, since catecholamine is a major factor for blood pressure regulation and Ascorbic Acid is a co-factor of dopamine beta-hydroxylase (DBH) in catecholamine biosynthesis. Male SHR-od (25-week-old) and normotensive ODS rats with a defect in Ascorbic Acid biosynthesis (25-week-old) were fed a Funabashi-SP diet with or without Ascorbic Acid (300 mg/kg diet) for 28 days or 35 days. In SHR-od, systolic blood pressure (191 +/- 6 mmHg) began to decrease from day 21 in the Ascorbic Acid-deficient group, whereas no significant difference was found in ODS rats. In spite of significant lowering of blood pressure, no significant differences were found in catecholamine levels in serum, adrenal glands and brain on day 28. On day 35, however, urinary excretion of norepinephrine and epinephrine in the Ascorbic Acid-deficient SHR-od were higher at 490% (P < 0.05) and 460% (P < 0.05) of the respective control. Serum catecholamine concentrations and the adrenal catecholamine content tended to be higher in the Ascorbic Acid-deficient SHR-od than the control of SHR-od and reached to similar level in ODS rats. The administration of Ascorbic Acid (intraperitoneal injection, 60 mg Ascorbic Acid/kg body weight, once a day) to the Ascorbic Acid-deficient SHR-od restored blood pressure to the range 180-190 mmHg within two days. These findings indicate that Ascorbic Acid deficiency affects catecholamine metabolism in the adrenal glands of SHR-od in response to blood pressure lowering, suggesting catecholamines are not involved in the mechanism for the remarkable reduction in blood pressure in response to Ascorbic Acid deficiency.

  • changes in catecholamine metabolism by Ascorbic Acid deficiency in spontaneously hypertensive rats unable to synthesize Ascorbic Acid
    Life Sciences, 2003
    Co-Authors: Kaori Kawai, Susumu Makino, Hiroyuki Ito, Hiroko Kubota, Kumiko Takemori, Fumihiko Horio
    Abstract:

    Abstract We have previously reported the establishment of a novel rat strain, SHR-od, with both spontaneous hypertension and a defect of Ascorbic Acid biosynthesis. Blood pressure in mature SHR-od fed an Ascorbic Acid-supplemented diet is over 190–200 mmHg, while it decreased to around 120 mmHg at 4–5 weeks after the cessation of Ascorbic Acid supplementation. With regard to possible mechanisms of blood pressure lowering, we focused on catecholamine synthesis in adrenal glands, since catecholamine is a major factor for blood pressure regulation and Ascorbic Acid is a co-factor of dopamine β-hydroxylase (DBH) in catecholamine biosynthesis. Male SHR-od (25-week-old) and normotensive ODS rats with a defect in Ascorbic Acid biosynthesis (25-week-old) were fed a Funabashi-SP diet with or without Ascorbic Acid (300 mg/kg diet) for 28 days or 35 days. In SHR-od, systolic blood pressure (191 ± 6 mmHg) began to decrease from day 21 in the Ascorbic Acid-deficient group, whereas no significant difference was found in ODS rats. In spite of significant lowering of blood pressure, no significant differences were found in catecholamine levels in serum, adrenal glands and brain on day 28. On day 35, however, urinary excretion of norepinephrine and epinephrine in the Ascorbic Acid-deficient SHR-od were higher at 490% (P

Gitte Hald Kristiansen - One of the best experts on this subject based on the ideXlab platform.

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of Agricultural and Food Chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin−Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals. Keywords: Ascorbic Acid; Ascorbic Acid 6-palmitate; oxidation; egg yolk; ph...

  • Ascorbic Acid and Ascorbic Acid 6-palmitate induced oxidation in egg yolk dispersions.
    Journal of agricultural and food chemistry, 2000
    Co-Authors: Jacob Holm Nielsen, Gitte Hald Kristiansen, Henrik J. Andersen
    Abstract:

    The oxidation in aqueous dispersions of egg yolk powder and the influence of addition of the proposed antioxidants Ascorbic Acid and Ascorbic Acid 6-palmitate indicate that both Ascorbic Acid and Ascorbic Acid 6-palmitate propagated the oxidation of egg yolk powder dispersions. Ascorbic Acid 6-palmitate was found to be more prooxidative than Ascorbic Acid. Moreover, it was found that addition of Ascorbic Acid or Ascorbic Acid 6-palmitate gave rise to an increase in the amount of free iron Fe(II) in the egg yolk dispersions. It is proposed that Ascorbic Acid and Ascorbic Acid 6-palmitate react with the phosvitin-Fe(III) complex found in egg yolk and release Fe(II), which subsequently propagates lipid oxidation. It appears that less oxidation occurs in egg yolk dispersions exposed to high concentrations of peroxy radicals with added Ascorbic Acid than egg yolk dispersions with added Ascorbic Acid without exposure to peroxy radicals.

Kaori Kawai - One of the best experts on this subject based on the ideXlab platform.

  • Changes in catecholamine metabolism by Ascorbic Acid deficiency in spontaneously hypertensive rats unable to synthesize Ascorbic Acid
    Life sciences, 2003
    Co-Authors: Kaori Kawai, Susumu Makino, Hiroyuki Ito, Hiroko Kubota, Kumiko Takemori, Fumihiko Horio
    Abstract:

    We have previously reported the establishment of a novel rat strain, SHR-od, with both spontaneous hypertension and a defect of Ascorbic Acid biosynthesis. Blood pressure in mature SHR-od fed an Ascorbic Acid-supplemented diet is over 190-200 mmHg, while it decreased to around 120 mmHg at 4-5 weeks after the cessation of Ascorbic Acid supplementation. With regard to possible mechanisms of blood pressure lowering, we focused on catecholamine synthesis in adrenal glands, since catecholamine is a major factor for blood pressure regulation and Ascorbic Acid is a co-factor of dopamine beta-hydroxylase (DBH) in catecholamine biosynthesis. Male SHR-od (25-week-old) and normotensive ODS rats with a defect in Ascorbic Acid biosynthesis (25-week-old) were fed a Funabashi-SP diet with or without Ascorbic Acid (300 mg/kg diet) for 28 days or 35 days. In SHR-od, systolic blood pressure (191 +/- 6 mmHg) began to decrease from day 21 in the Ascorbic Acid-deficient group, whereas no significant difference was found in ODS rats. In spite of significant lowering of blood pressure, no significant differences were found in catecholamine levels in serum, adrenal glands and brain on day 28. On day 35, however, urinary excretion of norepinephrine and epinephrine in the Ascorbic Acid-deficient SHR-od were higher at 490% (P < 0.05) and 460% (P < 0.05) of the respective control. Serum catecholamine concentrations and the adrenal catecholamine content tended to be higher in the Ascorbic Acid-deficient SHR-od than the control of SHR-od and reached to similar level in ODS rats. The administration of Ascorbic Acid (intraperitoneal injection, 60 mg Ascorbic Acid/kg body weight, once a day) to the Ascorbic Acid-deficient SHR-od restored blood pressure to the range 180-190 mmHg within two days. These findings indicate that Ascorbic Acid deficiency affects catecholamine metabolism in the adrenal glands of SHR-od in response to blood pressure lowering, suggesting catecholamines are not involved in the mechanism for the remarkable reduction in blood pressure in response to Ascorbic Acid deficiency.

  • changes in catecholamine metabolism by Ascorbic Acid deficiency in spontaneously hypertensive rats unable to synthesize Ascorbic Acid
    Life Sciences, 2003
    Co-Authors: Kaori Kawai, Susumu Makino, Hiroyuki Ito, Hiroko Kubota, Kumiko Takemori, Fumihiko Horio
    Abstract:

    Abstract We have previously reported the establishment of a novel rat strain, SHR-od, with both spontaneous hypertension and a defect of Ascorbic Acid biosynthesis. Blood pressure in mature SHR-od fed an Ascorbic Acid-supplemented diet is over 190–200 mmHg, while it decreased to around 120 mmHg at 4–5 weeks after the cessation of Ascorbic Acid supplementation. With regard to possible mechanisms of blood pressure lowering, we focused on catecholamine synthesis in adrenal glands, since catecholamine is a major factor for blood pressure regulation and Ascorbic Acid is a co-factor of dopamine β-hydroxylase (DBH) in catecholamine biosynthesis. Male SHR-od (25-week-old) and normotensive ODS rats with a defect in Ascorbic Acid biosynthesis (25-week-old) were fed a Funabashi-SP diet with or without Ascorbic Acid (300 mg/kg diet) for 28 days or 35 days. In SHR-od, systolic blood pressure (191 ± 6 mmHg) began to decrease from day 21 in the Ascorbic Acid-deficient group, whereas no significant difference was found in ODS rats. In spite of significant lowering of blood pressure, no significant differences were found in catecholamine levels in serum, adrenal glands and brain on day 28. On day 35, however, urinary excretion of norepinephrine and epinephrine in the Ascorbic Acid-deficient SHR-od were higher at 490% (P

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