The Experts below are selected from a list of 4578 Experts worldwide ranked by ideXlab platform
Yanyan Song - One of the best experts on this subject based on the ideXlab platform.
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Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong
2016Co-Authors: Suting Wang, Ning Cui, Yanyan SongAbstract:Background: Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives: To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design: Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results: A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions: Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis cause
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molecular epidemiology of human enterovirus associated with Aseptic Meningitis in shandong province china 2006 2012
PLOS ONE, 2014Co-Authors: Zexin Tao, Guifang Liu, Haiyan Wang, Lizhi Song, Xiaojuan Lin, Ning Cui, Suting Wang, Yanyan SongAbstract:Background Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis caused by EV71 and coxsackie A viruses–the predominant pathogens for the hand, foot, and mouth disease–is currently an important concern in mainland China.
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a coxsackievirus b5 associated Aseptic Meningitis outbreak in shandong province china in 2009
Journal of Medical Virology, 2013Co-Authors: Peng Chen, Zexin Tao, Yanyan Song, Guifang Liu, Haiyan Wang, Yao Liu, Lizhi Song, Xiaojuan Lin, Ning CuiAbstract:In 2009, a major outbreak of Aseptic Meningitis was noted in Linyi city, Shandong province, China. From June to September 2009, a total of 2,104 cases were involved in this outbreak, and 98.6% of patients were <16 years of age. To determine the pathogen of the outbreak, 42 cerebrospinal fluid specimens collected from Aseptic Meningitis cases were tested for cell culture, and 17 (40.5%) enteroviruses were isolated and identified as Coxsackievirus B5 (CVB5). Homologous comparison indicated that these isolates had 0-7.7% nucleotide divergence with each other. Phylogenetic reconstruction showed global CVB5 could be separated into four genogroups, and all Linyi CVB5 isolates belonged to the genogroup C which had been circulating for recent 27 years in Asia and Europe. Interestingly, two distinct lineages were observed for the 17 isolates in the phylogenetic tree, indicating that at least two different transmission chains of CVB5 were responsible for this outbreak. This study showed that CVB5-associated Aseptic Meningitis is an emerging concern in China.
Ning Cui - One of the best experts on this subject based on the ideXlab platform.
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Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong
2016Co-Authors: Suting Wang, Ning Cui, Yanyan SongAbstract:Background: Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives: To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design: Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results: A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions: Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis cause
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molecular epidemiology of human enterovirus associated with Aseptic Meningitis in shandong province china 2006 2012
PLOS ONE, 2014Co-Authors: Zexin Tao, Guifang Liu, Haiyan Wang, Lizhi Song, Xiaojuan Lin, Ning Cui, Suting Wang, Yanyan SongAbstract:Background Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis caused by EV71 and coxsackie A viruses–the predominant pathogens for the hand, foot, and mouth disease–is currently an important concern in mainland China.
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a coxsackievirus b5 associated Aseptic Meningitis outbreak in shandong province china in 2009
Journal of Medical Virology, 2013Co-Authors: Peng Chen, Zexin Tao, Yanyan Song, Guifang Liu, Haiyan Wang, Yao Liu, Lizhi Song, Xiaojuan Lin, Ning CuiAbstract:In 2009, a major outbreak of Aseptic Meningitis was noted in Linyi city, Shandong province, China. From June to September 2009, a total of 2,104 cases were involved in this outbreak, and 98.6% of patients were <16 years of age. To determine the pathogen of the outbreak, 42 cerebrospinal fluid specimens collected from Aseptic Meningitis cases were tested for cell culture, and 17 (40.5%) enteroviruses were isolated and identified as Coxsackievirus B5 (CVB5). Homologous comparison indicated that these isolates had 0-7.7% nucleotide divergence with each other. Phylogenetic reconstruction showed global CVB5 could be separated into four genogroups, and all Linyi CVB5 isolates belonged to the genogroup C which had been circulating for recent 27 years in Asia and Europe. Interestingly, two distinct lineages were observed for the 17 isolates in the phylogenetic tree, indicating that at least two different transmission chains of CVB5 were responsible for this outbreak. This study showed that CVB5-associated Aseptic Meningitis is an emerging concern in China.
Zexin Tao - One of the best experts on this subject based on the ideXlab platform.
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molecular epidemiology of human enterovirus associated with Aseptic Meningitis in shandong province china 2006 2012
PLOS ONE, 2014Co-Authors: Zexin Tao, Guifang Liu, Haiyan Wang, Lizhi Song, Xiaojuan Lin, Ning Cui, Suting Wang, Yanyan SongAbstract:Background Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis caused by EV71 and coxsackie A viruses–the predominant pathogens for the hand, foot, and mouth disease–is currently an important concern in mainland China.
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a coxsackievirus b5 associated Aseptic Meningitis outbreak in shandong province china in 2009
Journal of Medical Virology, 2013Co-Authors: Peng Chen, Zexin Tao, Yanyan Song, Guifang Liu, Haiyan Wang, Yao Liu, Lizhi Song, Xiaojuan Lin, Ning CuiAbstract:In 2009, a major outbreak of Aseptic Meningitis was noted in Linyi city, Shandong province, China. From June to September 2009, a total of 2,104 cases were involved in this outbreak, and 98.6% of patients were <16 years of age. To determine the pathogen of the outbreak, 42 cerebrospinal fluid specimens collected from Aseptic Meningitis cases were tested for cell culture, and 17 (40.5%) enteroviruses were isolated and identified as Coxsackievirus B5 (CVB5). Homologous comparison indicated that these isolates had 0-7.7% nucleotide divergence with each other. Phylogenetic reconstruction showed global CVB5 could be separated into four genogroups, and all Linyi CVB5 isolates belonged to the genogroup C which had been circulating for recent 27 years in Asia and Europe. Interestingly, two distinct lineages were observed for the 17 isolates in the phylogenetic tree, indicating that at least two different transmission chains of CVB5 were responsible for this outbreak. This study showed that CVB5-associated Aseptic Meningitis is an emerging concern in China.
Benedicte Lebrunvignes - One of the best experts on this subject based on the ideXlab platform.
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drug induced Aseptic Meningitis 329 cases from the french pharmacovigilance database analysis
British Journal of Clinical Pharmacology, 2019Co-Authors: Kevin Bihan, Nicolas Weiss, Helene Theophile, Christian Funckbrentano, Benedicte LebrunvignesAbstract:Aims Drug-induced Aseptic Meningitis (DIAM) is an adverse drug reaction of exclusion; only few studies have addressed this iatrogenic disease. The aim was to characterize DIAM and to identify suspected drugs. Methods Data were collected from the analysis of the French Pharmacovigilance Database from inception (1 January 1985) to 8 March 2017. All cases were initially analysed according to the French imputability method by institutional pharmacologists (clinicians or pharmacists). Further analyses of well documented cases were then performed. Results In this study, 329 cases of Aseptic Meningitis were retrieved from the French Pharmacovigilance Database for a total of 429 suspected drugs. Analysis of 203 well documented cases, including 282 drugs, showed that the main reported classes were intravenous polyvalent immunoglobulin, nonsteroidal anti-inflammatory drugs (NSAIDs), vaccines, antimicrobials, intrathecal antimetabolites, corticosteroids and antalgics/anaesthetics (except NSAIDs). Lymphocytic (33.0%) and purulent (44.8%) Meningitis represented the majority of cases of Aseptic Meningitis. In other cases, the cerebrospinal fluid was mixed (45-55% of neutrophils +45-55% of lymphocytes) or data about cerebrospinal fluid composition were lacking. Most DIAM cases (96%) had a favourable reported outcome with full recovery or minimal residual symptoms. Conclusion The most frequently involved drugs in DIAM were intravenous polyvalent immunoglobulin, NSAIDs, vaccines, and antimicrobials and this without being able to differentiate them in terms of biological characteristics. Although further studies are needed to better understand the pathophysiological mechanisms of DIAM, a continuous enrichment of pharmacovigilance databases is essential to identify new signals and to help clinicians in the understanding of DIAM.
Lizhi Song - One of the best experts on this subject based on the ideXlab platform.
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molecular epidemiology of human enterovirus associated with Aseptic Meningitis in shandong province china 2006 2012
PLOS ONE, 2014Co-Authors: Zexin Tao, Guifang Liu, Haiyan Wang, Lizhi Song, Xiaojuan Lin, Ning Cui, Suting Wang, Yanyan SongAbstract:Background Human enteroviruses (HEVs) are common causes of acute Meningitis. However, there is limited information about HEV associated with Aseptic Meningitis in mainland China because it has not been classified as a notifiable disease. Objectives To characterize the HEVs associated with sporadic Aseptic Meningitis in China and to analyze their genetic features. Study Design Cerebrospinal fluid, throat swab and feces specimens were collected from patients with Aseptic Meningitis in 5 sentinel hospitals in Shandong Province, China between 2006 and 2012. Virological investigation (viral isolation and molecular identification) and phylogenetic analysis were performed. Results A total of 437 hospitalized patients were reported, and enteroviruses were detected in the specimens from 84 patients (19.2%) and were identified into 17 serotypes. The nine main serotypes were echovirus (E) 30 (27.4%), EV71 (13.1%), coxsackievirus (CV) B1 (9.5%), CVB3 (7.1%), CVB5 (7.1%), E6 (7.1%), E9 (7.1%), CVA9 (6.0%), and CVA10 (3.6%). Monthly distribution of isolated enteroviruses revealed a major peak in summer-fall season and a small second peak in winter constituted totally by EV71. Sequence analysis on VP1 coding region suggested Shandong strains had great genetic divergence with isolates from other countries. Conclusions Multiple serotypes were responsible for enterovirus Meningitis in mainland China. Aseptic Meningitis caused by EV71 and coxsackie A viruses–the predominant pathogens for the hand, foot, and mouth disease–is currently an important concern in mainland China.
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a coxsackievirus b5 associated Aseptic Meningitis outbreak in shandong province china in 2009
Journal of Medical Virology, 2013Co-Authors: Peng Chen, Zexin Tao, Yanyan Song, Guifang Liu, Haiyan Wang, Yao Liu, Lizhi Song, Xiaojuan Lin, Ning CuiAbstract:In 2009, a major outbreak of Aseptic Meningitis was noted in Linyi city, Shandong province, China. From June to September 2009, a total of 2,104 cases were involved in this outbreak, and 98.6% of patients were <16 years of age. To determine the pathogen of the outbreak, 42 cerebrospinal fluid specimens collected from Aseptic Meningitis cases were tested for cell culture, and 17 (40.5%) enteroviruses were isolated and identified as Coxsackievirus B5 (CVB5). Homologous comparison indicated that these isolates had 0-7.7% nucleotide divergence with each other. Phylogenetic reconstruction showed global CVB5 could be separated into four genogroups, and all Linyi CVB5 isolates belonged to the genogroup C which had been circulating for recent 27 years in Asia and Europe. Interestingly, two distinct lineages were observed for the 17 isolates in the phylogenetic tree, indicating that at least two different transmission chains of CVB5 were responsible for this outbreak. This study showed that CVB5-associated Aseptic Meningitis is an emerging concern in China.
