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Aspartate Transaminase

The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform

Colin Deane – 1st expert on this subject based on the ideXlab platform

  • scanning in children with sickle cell anemia increased intracerebral blood velocity as measured by transcranial doppler a simple index using age hemoglobin and Aspartate Transaminase predicts
    , 2013
    Co-Authors: David Goss, David C Rees, Colin Deane, Moira C Dick, Sue Height, Sandra Odriscoll, Keith R E Pohl

    Abstract:

    ABSTRACT OBJECTIVE. Increased intracerebral blood velocity measured by transcranial Dopplerscanning identifies children with sickle cell anemia who are at increased risk ofstroke. We have tried to develop an index based on routine clinical measurementsthat also predicts increased intracerebral blood flow. METHOD. Routinely collected clinical and laboratory data were correlated with trans-cranial Doppler measurements on children with sickle cell anemia seen in a singleinstitution in 2006. The index produced was validated on a second independent dataset from children with sickle cell anemia. RESULTS. The time-averaged mean of the maximum velocity in centimeters per secondin the middle cerebral artery circulation correlated significantly with age, hemoglo-bin, lactate dehydrogenase, and Aspartate Transaminase levels, white blood cellcount, and creatinine level. On multiple regression, hemoglobin and AspartateTransaminase levels maintained their significance, whereas age had borderline sig-nificance, and an index was developed linked to a time-averaged mean of themaximum velocity of 220 (8 hemoglobin) (1.4 age) (0.4 AspartateTransaminase). This detected a time-averaged mean of the maximum velocity of170 cm/second with 100% sensitivity and 58% specificity. The index was validatedon the second data set and again showed 100% sensitivity with 73% specificity.

  • a simple index using age hemoglobin and Aspartate Transaminase predicts increased intracerebral blood velocity as measured by transcranial doppler scanning in children with sickle cell anemia
    Pediatrics, 2008
    Co-Authors: David C Rees, Moira C Dick, Sue Height, Sandra Odriscoll, Keith Pohl, David Goss, Colin Deane

    Abstract:

    OBJECTIVE: Increased intracerebral blood velocity measured by transcranial Doppler scanning identifies children with sickle cell anemia who are at increased risk of stroke. We have tried to develop an index based on routine clinical measurements that also predicts increased intracerebral blood flow. METHOD: Routinely collected clinical and laboratory data were correlated with transcranial Doppler measurements on children with sickle cell anemia seen in a single institution in 2006. The index produced was validated on a second independent data set from children with sickle cell anemia. RESULTS: The time-averaged mean of the maximum velocity in centimeters per second in the middle cerebral artery circulation correlated significantly with age, hemoglobin, lactate dehydrogenase, and Aspartate Transaminase levels, white blood cell count, and creatinine level. On multiple regression, hemoglobin and Aspartate Transaminase levels maintained their significance, whereas age had borderline significance, and an index was developed linked to a time-averaged mean of the maximum velocity of 220 – (8 x hemoglobin) – (1.4 x age) + (0.4 x Aspartate Transaminase). This detected a time-averaged mean of the maximum velocity of >170 cm/second with 100% sensitivity and 58% specificity. The index was validated on the second data set and again showed 100% sensitivity with 73% specificity. CONCLUSION: This simple index has the potential to identify children who are at higher risk of cerebrovascular disease to allow them to be prioritized for transcranial Doppler scanning and other intracerebral imaging.

David C Rees – 2nd expert on this subject based on the ideXlab platform

  • scanning in children with sickle cell anemia increased intracerebral blood velocity as measured by transcranial doppler a simple index using age hemoglobin and Aspartate Transaminase predicts
    , 2013
    Co-Authors: David Goss, David C Rees, Colin Deane, Moira C Dick, Sue Height, Sandra Odriscoll, Keith R E Pohl

    Abstract:

    ABSTRACT OBJECTIVE. Increased intracerebral blood velocity measured by transcranial Dopplerscanning identifies children with sickle cell anemia who are at increased risk ofstroke. We have tried to develop an index based on routine clinical measurementsthat also predicts increased intracerebral blood flow. METHOD. Routinely collected clinical and laboratory data were correlated with trans-cranial Doppler measurements on children with sickle cell anemia seen in a singleinstitution in 2006. The index produced was validated on a second independent dataset from children with sickle cell anemia. RESULTS. The time-averaged mean of the maximum velocity in centimeters per secondin the middle cerebral artery circulation correlated significantly with age, hemoglo-bin, lactate dehydrogenase, and Aspartate Transaminase levels, white blood cellcount, and creatinine level. On multiple regression, hemoglobin and AspartateTransaminase levels maintained their significance, whereas age had borderline sig-nificance, and an index was developed linked to a time-averaged mean of themaximum velocity of 220 (8 hemoglobin) (1.4 age) (0.4 AspartateTransaminase). This detected a time-averaged mean of the maximum velocity of170 cm/second with 100% sensitivity and 58% specificity. The index was validatedon the second data set and again showed 100% sensitivity with 73% specificity.

  • a simple index using age hemoglobin and Aspartate Transaminase predicts increased intracerebral blood velocity as measured by transcranial doppler scanning in children with sickle cell anemia
    Pediatrics, 2008
    Co-Authors: David C Rees, Moira C Dick, Sue Height, Sandra Odriscoll, Keith Pohl, David Goss, Colin Deane

    Abstract:

    OBJECTIVE: Increased intracerebral blood velocity measured by transcranial Doppler scanning identifies children with sickle cell anemia who are at increased risk of stroke. We have tried to develop an index based on routine clinical measurements that also predicts increased intracerebral blood flow. METHOD: Routinely collected clinical and laboratory data were correlated with transcranial Doppler measurements on children with sickle cell anemia seen in a single institution in 2006. The index produced was validated on a second independent data set from children with sickle cell anemia. RESULTS: The time-averaged mean of the maximum velocity in centimeters per second in the middle cerebral artery circulation correlated significantly with age, hemoglobin, lactate dehydrogenase, and Aspartate Transaminase levels, white blood cell count, and creatinine level. On multiple regression, hemoglobin and Aspartate Transaminase levels maintained their significance, whereas age had borderline significance, and an index was developed linked to a time-averaged mean of the maximum velocity of 220 – (8 x hemoglobin) – (1.4 x age) + (0.4 x Aspartate Transaminase). This detected a time-averaged mean of the maximum velocity of >170 cm/second with 100% sensitivity and 58% specificity. The index was validated on the second data set and again showed 100% sensitivity with 73% specificity. CONCLUSION: This simple index has the potential to identify children who are at higher risk of cerebrovascular disease to allow them to be prioritized for transcranial Doppler scanning and other intracerebral imaging.

Seock Hwan Choi – 3rd expert on this subject based on the ideXlab platform

  • the de ritis Aspartate Transaminase alanine Transaminase ratio as a predictor of oncological outcomes in patients after surgery for upper urinary tract urothelial carcinoma
    International Urology and Nephrology, 2017
    Co-Authors: Jun Eul Hwang, Ho Seok Chung, Eu Chang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Seock Hwan Choi, Tae Gyun Kwon, Sung Gu Kang, Seok Ho Kang

    Abstract:

    Purpose
    Recently, several studies have shown that the De Ritis ratio (Aspartate Transaminase/alanine Transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma.

  • The De Ritis (Aspartate Transaminase/alanine Transaminase) ratio as a predictor of oncological outcomes in patients after surgery for upper urinary tract urothelial carcinoma.
    International Urology and Nephrology, 2017
    Co-Authors: Jun Eul Hwang, Ho Seok Chung, Eu Chang Hwang, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Seock Hwan Choi

    Abstract:

    Purpose
    Recently, several studies have shown that the De Ritis ratio (Aspartate Transaminase/alanine Transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma.