The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Robert Gerlai - One of the best experts on this subject based on the ideXlab platform.
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Associative Learning in zebrafish danio rerio in the plus maze
Behavioural Brain Research, 2010Co-Authors: Margarette Sison, Robert GerlaiAbstract:Zebrafish has been gaining increasing amount of interest in behavioral neuroscience as this species may represent a good compromise between system complexity and practical simplicity. Particularly successful have been those studies that utilized zebrafish as a screening tool. Given the complexity of the mechanisms of Learning, for example, forward genetic screens with zebrafish could potentially reveal previously unknown genes and molecular pathways that subserve this function. These screens, however, require appropriate phenotypical (e.g. behavioral) paradigms. A step in this direction is the characterization of Learning abilities of zebrafish. Here we employ two classical Learning tasks in a plus maze. In the first, zebrafish are required to associate a visible cue with food reward irrespective of the location of this pairing. In the second, zebrafish are required to associate the spatial location of food reward irrespective of intra-maze cues. Our results demonstrate that zebrafish perform well in both tasks and show significant acquisition of the association between cue and reward as well as between location and reward. We conclude that zebrafish, similar to classical laboratory rodents, may have utility in the biological analysis of simple as well as complex forms of Associative Learning.
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sight of conspecifics as reward in Associative Learning in zebrafish danio rerio
Behavioural Brain Research, 2008Co-Authors: Lina Alimari, Robert GerlaiAbstract:Large amount of genetic information has been accumulated for zebrafish. Learning and memory have also been investigated with zebrafish but the number of Learning paradigms is limited. Here we present a simple Associative task and investigate a novel reinforcer. We show that visual access to a group of conspecifics has rewarding properties and that this reinforcer can support Associative Learning in zebrafish. We discuss the advantages of this rewarding stimulus and make recommendations for its use in high throughput behavioral screens.
Milica Markovic - One of the best experts on this subject based on the ideXlab platform.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
Nature Neuroscience, 2019Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Julien Courtin, Keisuke Yonehara, Milica MarkovicAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning has been extensively studied, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we found that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing deep-brain calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide a mandatory disinhibitory signal for Associative Learning. Notably, VIP interneuron responses during Learning are strongly modulated by expectations. Our findings indicate that VIP interneurons are a central component of a dynamic circuit motif that mediates adaptive disinhibitory gating to specifically learn about unexpected, salient events, thereby ensuring appropriate behavioral adaptations.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
bioRxiv, 2018Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Keisuke Yonehara, Milica Markovic, Jan GrundemannAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning is studied extensively, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we find that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide an instructive disinhibitory signal for Associative Learning. Notably, VIP interneuron responses are plastic and shift from the instructive to the predictive cue upon memory formation. We describe a novel form of adaptive disinhibitory gating by VIP interneurons that allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific Learning, thereby ensuring appropriate behavioral adaptations to salient events.
Simon Daquin - One of the best experts on this subject based on the ideXlab platform.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
Nature Neuroscience, 2019Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Julien Courtin, Keisuke Yonehara, Milica MarkovicAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning has been extensively studied, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we found that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing deep-brain calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide a mandatory disinhibitory signal for Associative Learning. Notably, VIP interneuron responses during Learning are strongly modulated by expectations. Our findings indicate that VIP interneurons are a central component of a dynamic circuit motif that mediates adaptive disinhibitory gating to specifically learn about unexpected, salient events, thereby ensuring appropriate behavioral adaptations.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
bioRxiv, 2018Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Keisuke Yonehara, Milica Markovic, Jan GrundemannAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning is studied extensively, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we find that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide an instructive disinhibitory signal for Associative Learning. Notably, VIP interneuron responses are plastic and shift from the instructive to the predictive cue upon memory formation. We describe a novel form of adaptive disinhibitory gating by VIP interneurons that allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific Learning, thereby ensuring appropriate behavioral adaptations to salient events.
Enrica Paradiso - One of the best experts on this subject based on the ideXlab platform.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
Nature Neuroscience, 2019Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Julien Courtin, Keisuke Yonehara, Milica MarkovicAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning has been extensively studied, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we found that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing deep-brain calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide a mandatory disinhibitory signal for Associative Learning. Notably, VIP interneuron responses during Learning are strongly modulated by expectations. Our findings indicate that VIP interneurons are a central component of a dynamic circuit motif that mediates adaptive disinhibitory gating to specifically learn about unexpected, salient events, thereby ensuring appropriate behavioral adaptations.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
bioRxiv, 2018Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Keisuke Yonehara, Milica Markovic, Jan GrundemannAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning is studied extensively, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we find that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide an instructive disinhibitory signal for Associative Learning. Notably, VIP interneuron responses are plastic and shift from the instructive to the predictive cue upon memory formation. We describe a novel form of adaptive disinhibitory gating by VIP interneurons that allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific Learning, thereby ensuring appropriate behavioral adaptations to salient events.
Keisuke Yonehara - One of the best experts on this subject based on the ideXlab platform.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
Nature Neuroscience, 2019Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Julien Courtin, Keisuke Yonehara, Milica MarkovicAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning has been extensively studied, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we found that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing deep-brain calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide a mandatory disinhibitory signal for Associative Learning. Notably, VIP interneuron responses during Learning are strongly modulated by expectations. Our findings indicate that VIP interneurons are a central component of a dynamic circuit motif that mediates adaptive disinhibitory gating to specifically learn about unexpected, salient events, thereby ensuring appropriate behavioral adaptations.
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adaptive disinhibitory gating by vip interneurons permits Associative Learning
bioRxiv, 2018Co-Authors: Sabine Krabbe, Enrica Paradiso, Simon Daquin, Yael Bitterman, Keisuke Yonehara, Milica Markovic, Jan GrundemannAbstract:Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during Associative Learning is studied extensively, little is known about the contributions of local interneurons. Using fear conditioning as a model for Associative Learning, we find that behaviorally relevant, salient stimuli cause Learning by tapping into a local microcircuit consisting of precisely connected subtypes of inhibitory interneurons. By employing calcium imaging and optogenetics, we demonstrate that vasoactive intestinal peptide (VIP)-expressing interneurons in the basolateral amygdala are activated by aversive events and provide an instructive disinhibitory signal for Associative Learning. Notably, VIP interneuron responses are plastic and shift from the instructive to the predictive cue upon memory formation. We describe a novel form of adaptive disinhibitory gating by VIP interneurons that allows to discriminate unexpected, important from irrelevant information, and might be a general dynamic circuit motif to trigger stimulus-specific Learning, thereby ensuring appropriate behavioral adaptations to salient events.
