The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Anna K. Kiss - One of the best experts on this subject based on the ideXlab platform.
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The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material.
Journal of Pharmaceutical and Biomedical Analysis, 2015Co-Authors: Sebastian Granica, Holger Kluge, Gert Horn, Adam Matkowski, Anna K. KissAbstract:Abstract The agrimony herb is a traditional plant drug, which is commonly used as a mildly Astringent Agent. According to European Pharmacopoeia, the only source of this plant drug is Agrimonia eupatoria . By contrast the German Commission E pharmacopoeial monograph used to allow Agrimonia procera to be used as a second valid source of Agrimoniae herba . Several studies have been conducted on the phytochemical composition of common agrimony. The data on the phytochemistry of A. procera are scarce. The aim of the present study was an in-depth phytochemical comparison of A. eupatoria and A. procera in the context of the pharmacopoeial monograph of A. herba . The comparison of two agrimony species showed that there are no significant qualitative differences. The quantitative HPLC analysis revealed that fragrant agrimony is a much better source of agrimoniin than common agrimony. This difference could not be detected using the pharmacopoeial method of quantification for the total tannin content. The present study has shown for the first time the possible use of apigenin- C- glycosides (vitexin and isovitexin) as chemotaxonomic markers for distinguishing both agrimony species. The potential chemical markers such as apigenin-7- O -glucoside and high agrimoniin content were also suggested for fragrant agrimony. Based on the data obtained, A. procera should be considered as a valid source of pharmacopoeial plant material.
Diógenes Aparício Garcia Cortez - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil.
Public Library of Science (PLoS), 2024Co-Authors: Jackeline Tiemy Guinoza Siraichi, Daniele Fernanda Felipe, Lara Zampar Serra Brambilla, Melissa Junqueira Gatto, Vânia Aparecida Terra, Alessandra Lourenco Cecchini, Lucia Elaine Ranieri Cortez, Edson Rodrigues-filho, Diógenes Aparício Garcia CortezAbstract:Arrabidaea chica leaf extract has been used by people as an anti-inflammatory and Astringent Agent as well as a remedy for intestinal colic, diarrhea, leucorrhea, anemia, and leukemia. A. chica is known to be a good producer of phenolics. Therefore, in the present study, we investigated its antioxidant activity. The phenolic composition of A. chica leaves was studied by liquid chromatography coupled to diode array detection (LC-DAD) and liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS), and isoscutellarein, 6-hydroxyluteolin, hispidulin, scutellarein, luteolin, and apigenin were identified. The extract from leaves of A. chica was tested for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, β-carotene bleaching test, and total reactive antioxidant potential (TRAP) method. The crude extract quenched DPPH free radicals in a dose-dependent manner, and the IC50 of the extract was 13.51 µg/mL. The β-carotene bleaching test showed that the addition of the A. chica extract in different concentrations (200 and 500 µg/mL) prevented the bleaching of β-carotene at different degrees (51.2% ±3.38% and 94% ±4.61%, respectively). The TRAP test showed dose-dependent correlation between the increasing concentrations of A. chica extract (0.1, 0.5, and 1.0 µg/mL) and the TRAP values obtained by trolox (hydro-soluble vitamin E) 0.4738±0.0466, 1.981±0.1603, and 6.877±1.445 µM, respectively. The 2 main flavonoids, scutellarein and apigenin, were separated, and their antioxidant activity was found to be the same as that of the plant extract. These 2 flavonoids were quantified in the plant extract by using a validated HPLC-UV method. The results of these tests showed that the extract of A. chica had a significant antioxidant activity, which could be attributed to the presence of the mixture of flavonoids in the plant extract, with the main contribution of scutellarein and apigenin
Lucia Elaine - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant Capacity of the Leaf Extract Obtained from Arrabidaea chica Cultivated in Southern Brazil
2016Co-Authors: Jackeline Tiemy, Guinoza Siraichi, Daniele Fern, A Felipe, Lara Zampar, Serra Brambilla, Junqueira Gatto, Vânia Aparecida Terra, Ra Lourenco Cecchini, Lucia ElaineAbstract:Arrabidaea chica leaf extract has been used by people as an anti-inflammatory and Astringent Agent as well as a remedy for intestinal colic, diarrhea, leucorrhea, anemia, and leukemia. A. chica is known to be a good producer of phenolics. Therefore, in the present study, we investigated its antioxidant activity. The phenolic composition of A. chica leaves was studied by liquid chromatography coupled to diode array detection (LC–DAD) and liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS), and isoscutellarein, 6-hydroxyluteolin, hispidulin, scutellarein, luteolin, and apigenin were identified. The extract from leaves of A. chica was tested for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, b-carotene bleaching test, and total reactive antioxidant potential (TRAP) method. The crude extract quenched DPPH free radicals in a dose-dependent manner, and the IC50 of the extract was 13.51 mg/mL. The b-carotene bleaching test showed that the addition of the A. chica extract in different concentrations (200 and 500 mg/mL) prevented the bleaching of b-carotene at different degrees (51.2 % 63.38 % and 94 % 64.61%, respectively). The TRAP test showed dose-dependent correlation between the increasing concentrations of A. chica extract (0.1, 0.5, and 1.0 mg/mL) and the TRAP values obtained by trolox (hydro-soluble vitamin E) 0.473860.0466, 1.98160.1603, an
Sebastian Granica - One of the best experts on this subject based on the ideXlab platform.
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The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba--The pharmacopoeial plant material.
Journal of Pharmaceutical and Biomedical Analysis, 2015Co-Authors: Sebastian Granica, Holger Kluge, Gert Horn, Adam Matkowski, Anna K. KissAbstract:Abstract The agrimony herb is a traditional plant drug, which is commonly used as a mildly Astringent Agent. According to European Pharmacopoeia, the only source of this plant drug is Agrimonia eupatoria . By contrast the German Commission E pharmacopoeial monograph used to allow Agrimonia procera to be used as a second valid source of Agrimoniae herba . Several studies have been conducted on the phytochemical composition of common agrimony. The data on the phytochemistry of A. procera are scarce. The aim of the present study was an in-depth phytochemical comparison of A. eupatoria and A. procera in the context of the pharmacopoeial monograph of A. herba . The comparison of two agrimony species showed that there are no significant qualitative differences. The quantitative HPLC analysis revealed that fragrant agrimony is a much better source of agrimoniin than common agrimony. This difference could not be detected using the pharmacopoeial method of quantification for the total tannin content. The present study has shown for the first time the possible use of apigenin- C- glycosides (vitexin and isovitexin) as chemotaxonomic markers for distinguishing both agrimony species. The potential chemical markers such as apigenin-7- O -glucoside and high agrimoniin content were also suggested for fragrant agrimony. Based on the data obtained, A. procera should be considered as a valid source of pharmacopoeial plant material.
Jackeline Tiemy Guinoza Siraichi - One of the best experts on this subject based on the ideXlab platform.
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Antioxidant capacity of the leaf extract obtained from Arrabidaea chica cultivated in Southern Brazil.
Public Library of Science (PLoS), 2024Co-Authors: Jackeline Tiemy Guinoza Siraichi, Daniele Fernanda Felipe, Lara Zampar Serra Brambilla, Melissa Junqueira Gatto, Vânia Aparecida Terra, Alessandra Lourenco Cecchini, Lucia Elaine Ranieri Cortez, Edson Rodrigues-filho, Diógenes Aparício Garcia CortezAbstract:Arrabidaea chica leaf extract has been used by people as an anti-inflammatory and Astringent Agent as well as a remedy for intestinal colic, diarrhea, leucorrhea, anemia, and leukemia. A. chica is known to be a good producer of phenolics. Therefore, in the present study, we investigated its antioxidant activity. The phenolic composition of A. chica leaves was studied by liquid chromatography coupled to diode array detection (LC-DAD) and liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS), and isoscutellarein, 6-hydroxyluteolin, hispidulin, scutellarein, luteolin, and apigenin were identified. The extract from leaves of A. chica was tested for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, β-carotene bleaching test, and total reactive antioxidant potential (TRAP) method. The crude extract quenched DPPH free radicals in a dose-dependent manner, and the IC50 of the extract was 13.51 µg/mL. The β-carotene bleaching test showed that the addition of the A. chica extract in different concentrations (200 and 500 µg/mL) prevented the bleaching of β-carotene at different degrees (51.2% ±3.38% and 94% ±4.61%, respectively). The TRAP test showed dose-dependent correlation between the increasing concentrations of A. chica extract (0.1, 0.5, and 1.0 µg/mL) and the TRAP values obtained by trolox (hydro-soluble vitamin E) 0.4738±0.0466, 1.981±0.1603, and 6.877±1.445 µM, respectively. The 2 main flavonoids, scutellarein and apigenin, were separated, and their antioxidant activity was found to be the same as that of the plant extract. These 2 flavonoids were quantified in the plant extract by using a validated HPLC-UV method. The results of these tests showed that the extract of A. chica had a significant antioxidant activity, which could be attributed to the presence of the mixture of flavonoids in the plant extract, with the main contribution of scutellarein and apigenin
