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Ayman I Sayegh - One of the best experts on this subject based on the ideXlab platform.

  • Atropine Methyl Nitrate increases myenteric but not dorsal vagal complex Fos-like immunoreactivity in the rat.
    Physiology & behavior, 2006
    Co-Authors: Shannon J Raboin, Stephen Gulley, Sheryce C Henley, Wai-chu Chan, Alton R Esdaile, Ayman I Sayegh
    Abstract:

    Atropine Methyl Nitrate (AMN, 0.05, 0.5 and 25 mg/kg) intraperitoneally increased Fos-like immunoreactivity (Fos-LI) in the myenteric plexus, but not the dorsal vagal complex (DVC, the area postrema (AP), nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV)) in adult, male Sprague-Dawley rats. A 3 mg/kg AMN dose decreased intake of 15% sucrose, but failed to increase Fos-LI in both locations. In conclusion, the myenteric plexus may play a local role in the behavioral response evoked by AMN.

Shannon J Raboin - One of the best experts on this subject based on the ideXlab platform.

  • Atropine Methyl Nitrate increases myenteric but not dorsal vagal complex Fos-like immunoreactivity in the rat.
    Physiology & behavior, 2006
    Co-Authors: Shannon J Raboin, Stephen Gulley, Sheryce C Henley, Wai-chu Chan, Alton R Esdaile, Ayman I Sayegh
    Abstract:

    Atropine Methyl Nitrate (AMN, 0.05, 0.5 and 25 mg/kg) intraperitoneally increased Fos-like immunoreactivity (Fos-LI) in the myenteric plexus, but not the dorsal vagal complex (DVC, the area postrema (AP), nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV)) in adult, male Sprague-Dawley rats. A 3 mg/kg AMN dose decreased intake of 15% sucrose, but failed to increase Fos-LI in both locations. In conclusion, the myenteric plexus may play a local role in the behavioral response evoked by AMN.

Jiande D.z. Chen - One of the best experts on this subject based on the ideXlab platform.

  • Roles of putative neurotransmitters in the regulation of gastric and intestinal slow waves in conscious dogs
    Journal of gastroenterology and hepatology, 2007
    Co-Authors: Shi Liu, Jiande D.z. Chen
    Abstract:

    Background and Aims:  Slow waves play an important role in controlling the frequency and propagation of gastrointestinal contractions. However, mechanisms involved in the modulation of slow wave activity in vivo are still unclear. In this study, the roles of different neurotransmitters in the regulation of gastrointestinal slow waves were investigated in conscious dogs. Methods:  Female dogs implanted with electrodes in the stomach and the small bowel were used in a seven-session study. Gastrointestinal myoelectrical activity was recorded at baseline and after i.v. saline, Atropine, Atropine Methyl Nitrate, guanethidine, Nω-nitro-L-arginine (L-NNA), ondansetron or naloxone. Results:  Both Atropine and Atropine Methyl Nitrate induced tachygastria, bradygastria and arrhythmia. No difference was noted in the effects between Atropine and Atropine Methyl Nitrate. L-NNA increased the dominant frequency of small-intestinal slow waves but had no effect on gastric slow waves. Guanethidine, ondansetron and naloxone did not affect the dominant frequency, power or percentage of normal gastrointestinal slow waves. Conclusion:  Acetylcholine acting at muscarinic receptors seems to play an important role in the regulation of gastric slow waves. Nitric oxide may play a role in modulating intestinal slow waves but not gastric slow waves. Sympathetic pathways, 5-HT3 receptors and opioid receptors (especially μ-opioid receptors) do not play a role in the regulation of gastric or intestinal slow waves under normal physiological conditions.

Christopher J. Klinko - One of the best experts on this subject based on the ideXlab platform.

  • Separate controls for conditioned cephalic phases of acid secretion and drinking in the rat.
    Physiology & Behavior, 2003
    Co-Authors: F. Scott Kraly, Christopher J. Klinko
    Abstract:

    Abstract Adult male Sprague-Dawley rats, surgically equipped with a stainless steel gastric cannula, were tested in a paradigm known to support conditioning of cephalic phase gastric acid secretion. Rats were tested first under (a) baseline conditions—prepared to sham feed, but no food was offered and none should have been expected; then (b) 5 conditioning trials—prepared and allowed to sham feed sweetened milk; and finally (c) extinction trials—prepared to sham feed milk, but milk was not offered. Combined antagonism of H 1 and H 2 histamine receptors (using intraperitoneal dexbrompheniramine plus cimetidine) prevented the acquisition of conditioned cephalic phase of acid secretion, but had no effect on acquisition of conditioned water intake. Such histaminergic antagonism also blocked the expression of an established conditioned acid secretory response without effect on conditioned water intake; peripheral cholinergic blockade using Atropine Methyl Nitrate had virtually the same effect as did histaminergic antagonism. The converse was observed following blockade of angiotensin II synthesis using subcutaneous captopril: Established conditioned secretion was unaffected, but conditioned water intake was inhibited. These results dissociate the physiological controls for conditioned responses which occur simultaneously in rats anticipating eating: Peripheral histamine mediates the acquisition and expression of the conditioned cephalic phase of acid secretion, whereas angiotensin II appears to mediate at least the expression of conditioned water intake.

Alton R Esdaile - One of the best experts on this subject based on the ideXlab platform.

  • Atropine Methyl Nitrate increases myenteric but not dorsal vagal complex Fos-like immunoreactivity in the rat.
    Physiology & behavior, 2006
    Co-Authors: Shannon J Raboin, Stephen Gulley, Sheryce C Henley, Wai-chu Chan, Alton R Esdaile, Ayman I Sayegh
    Abstract:

    Atropine Methyl Nitrate (AMN, 0.05, 0.5 and 25 mg/kg) intraperitoneally increased Fos-like immunoreactivity (Fos-LI) in the myenteric plexus, but not the dorsal vagal complex (DVC, the area postrema (AP), nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV)) in adult, male Sprague-Dawley rats. A 3 mg/kg AMN dose decreased intake of 15% sucrose, but failed to increase Fos-LI in both locations. In conclusion, the myenteric plexus may play a local role in the behavioral response evoked by AMN.