The Experts below are selected from a list of 59637 Experts worldwide ranked by ideXlab platform
Markus Heilig - One of the best experts on this subject based on the ideXlab platform.
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increased Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with alcohol dependence in central sweden
Neuropsychopharmacology, 2005Co-Authors: Gavin Bart, Markus Heilig, Lotta Pollak, Jurg Ott, Mary Jeanne Kreek, Steven K Laforge, Dmitri ProudnikovAbstract:The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies. We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and receptors encoded by the variant 118G allele bind the endogenous opioid peptide beta-endorphin with three-fold greater affinity than prototype receptors. Other groups subsequently reported that this variant alters stress-responsivity in normal volunteers and also increases the therapeutic response to naltrexone (a mu-preferring opioid antagonist) in the treatment of alcohol dependence. We compared frequencies of genotypes containing an 118G allele in 389 alcohol-dependent individuals and 170 population-based controls without drug or alcohol abuse or dependence. The A118G SNP was present in the Hardy-Weinberg equilibrium with an overall frequency of the 118G allele of 10.9%. There was a significant overall association between genotypes with an 118G allele and alcohol dependence (p=0.0074). The Attributable Risk for alcohol dependence in subjects with an 118G allele was 11.1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased Attributable Risk for alcohol dependence.
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increased Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with alcohol dependence in central sweden
Neuropsychopharmacology, 2005Co-Authors: Gavin Bart, Markus Heilig, Lotta Pollak, Mary Jeanne Kreek, Steven K Laforge, Dmitri ProudnikovAbstract:The μ-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies. We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and receptors encoded by the variant 118G allele bind the endogenous opioid peptide β-endorphin with three-fold greater affinity than prototype receptors. Other groups subsequently reported that this variant alters stress-responsivity in normal volunteers and also increases the therapeutic response to naltrexone (a μ-preferring opioid antagonist) in the treatment of alcohol dependence. We compared frequencies of genotypes containing an 118G allele in 389 alcohol-dependent individuals and 170 population-based controls without drug or alcohol abuse or dependence. The A118G SNP was present in the Hardy–Weinberg equilibrium with an overall frequency of the 118G allele of 10.9%. There was a significant overall association between genotypes with an 118G allele and alcohol dependence (p=0.0074). The Attributable Risk for alcohol dependence in subjects with an 118G allele was 11.1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased Attributable Risk for alcohol dependence.
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substantial Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with heroin addiction in central sweden
Molecular Psychiatry, 2004Co-Authors: Gavin Bart, Markus Heilig, K S Laforge, Lotta Pollak, Suzanne M Leal, Jurg Ott, Mary Jeanne KreekAbstract:Substantial Attributable Risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden
Mary Jeanne Kreek - One of the best experts on this subject based on the ideXlab platform.
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increased Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with alcohol dependence in central sweden
Neuropsychopharmacology, 2005Co-Authors: Gavin Bart, Markus Heilig, Lotta Pollak, Jurg Ott, Mary Jeanne Kreek, Steven K Laforge, Dmitri ProudnikovAbstract:The mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies. We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and receptors encoded by the variant 118G allele bind the endogenous opioid peptide beta-endorphin with three-fold greater affinity than prototype receptors. Other groups subsequently reported that this variant alters stress-responsivity in normal volunteers and also increases the therapeutic response to naltrexone (a mu-preferring opioid antagonist) in the treatment of alcohol dependence. We compared frequencies of genotypes containing an 118G allele in 389 alcohol-dependent individuals and 170 population-based controls without drug or alcohol abuse or dependence. The A118G SNP was present in the Hardy-Weinberg equilibrium with an overall frequency of the 118G allele of 10.9%. There was a significant overall association between genotypes with an 118G allele and alcohol dependence (p=0.0074). The Attributable Risk for alcohol dependence in subjects with an 118G allele was 11.1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased Attributable Risk for alcohol dependence.
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increased Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with alcohol dependence in central sweden
Neuropsychopharmacology, 2005Co-Authors: Gavin Bart, Markus Heilig, Lotta Pollak, Mary Jeanne Kreek, Steven K Laforge, Dmitri ProudnikovAbstract:The μ-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies. We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and receptors encoded by the variant 118G allele bind the endogenous opioid peptide β-endorphin with three-fold greater affinity than prototype receptors. Other groups subsequently reported that this variant alters stress-responsivity in normal volunteers and also increases the therapeutic response to naltrexone (a μ-preferring opioid antagonist) in the treatment of alcohol dependence. We compared frequencies of genotypes containing an 118G allele in 389 alcohol-dependent individuals and 170 population-based controls without drug or alcohol abuse or dependence. The A118G SNP was present in the Hardy–Weinberg equilibrium with an overall frequency of the 118G allele of 10.9%. There was a significant overall association between genotypes with an 118G allele and alcohol dependence (p=0.0074). The Attributable Risk for alcohol dependence in subjects with an 118G allele was 11.1%. There was no difference in A118G genotype between type 1 and type 2 alcoholics. In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased Attributable Risk for alcohol dependence.
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substantial Attributable Risk related to a functional mu opioid receptor gene polymorphism in association with heroin addiction in central sweden
Molecular Psychiatry, 2004Co-Authors: Gavin Bart, Markus Heilig, K S Laforge, Lotta Pollak, Suzanne M Leal, Jurg Ott, Mary Jeanne KreekAbstract:Substantial Attributable Risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden
Lin Cai - One of the best experts on this subject based on the ideXlab platform.
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tobacco smoking alcohol drinking betel quid chewing and the Risk of head and neck cancer in an east asian population
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2018Co-Authors: Yuan Chin Amy Lee, Yuji Chen, Chienjen Chen, Wan Lun Hsu, Peijen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Lin CaiAbstract:BACKGROUND The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer Risk in East Asia. METHODS A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. RESULTS Head and neck cancer Risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total Attributable Risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (Attributable Risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. CONCLUSIONS Betel quid chewing is the strongest Risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. POPULATIONS
Chienjen Chen - One of the best experts on this subject based on the ideXlab platform.
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tobacco smoking alcohol drinking betel quid chewing and the Risk of head and neck cancer in an east asian population
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2018Co-Authors: Yuan Chin Amy Lee, Yuji Chen, Chienjen Chen, Wan Lun Hsu, Peijen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Lin CaiAbstract:BACKGROUND The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer Risk in East Asia. METHODS A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. RESULTS Head and neck cancer Risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total Attributable Risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (Attributable Risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. CONCLUSIONS Betel quid chewing is the strongest Risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. POPULATIONS
Yuan Chin Amy Lee - One of the best experts on this subject based on the ideXlab platform.
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tobacco smoking alcohol drinking betel quid chewing and the Risk of head and neck cancer in an east asian population
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2018Co-Authors: Yuan Chin Amy Lee, Yuji Chen, Chienjen Chen, Wan Lun Hsu, Peijen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Lin CaiAbstract:BACKGROUND The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer Risk in East Asia. METHODS A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. RESULTS Head and neck cancer Risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total Attributable Risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (Attributable Risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. CONCLUSIONS Betel quid chewing is the strongest Risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. POPULATIONS
