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Pedro Cobo - One of the best experts on this subject based on the ideXlab platform.
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Auditory Discrimination training for tinnitus treatment the effect of different paradigms
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, J. M. Aparicio, A ToledanoAbstract:Acoustic deprivation, i.e. hearing loss, is responsible for a cascade of processes resulting in reorganisation of the cortex. Tinnitus mechanisms are explained by synchronization of the neural spontaneous activity and might be related to cortical re-mapping. Auditory Discrimination training (ADT) has demonstrated in both animals and humans to induce tonotopical changes in the Auditory pathways through neural plasticity. We hypothesize that ADT could have some effect on tinnitus perception. The objective of this study is to compare the effect on tinnitus following two paradigms of ADT. Only patients from 20 to 60 years of age were recruited. Inclusion criteria were pure tone tinnitus of mild or moderate handicap according to the Tinnitus Handicap Inventory score (<56). ADT patients were randomized in two groups: SAME (ADT in the same frequency of tinnitus pitch, 20 patients) and NONSAME (ADT in the frequency one-octave below tinnitus pitch, 21 patients). Groups of pair of tones (70% standard tones ST, 30% deviant tones ST + 0.1–0.5 kHz) were randomly mixed for 20 min/day during 1 month. Patient had to mark when the two sounds of the pair were similar or different. Control group included 26 patients from the waiting list (WLG). Patients were also divided according to the trained frequency and the deepest hearing-impaired frequency. Outcome parameters were set up according to the answer to the question “is your tinnitus better, same, or worse with the treatment?” (RESP), the tinnitus handicap inventory (THI) and the visual analogue scale from 1 to 10 on tinnitus intensity (VAS). Tinnitus improved in 42.2% of the patients (RESP). VAS and THI scores were reduced but only THI differences were statistically significant (P = 0.003). ADT patients improved significantly compared with WLG in RESP and THI scores (P < 0.01). Training frequencies one-octave below the tinnitus pitch (NONSAME) decreased significantly THI scores compared with patients trained frequencies similar to tinnitus pitch (SAME, P = 0.035). RESP and VAS scores decreased more in NONSAME group though differences were not significant. We did not find any differences when comparing the group training the deepest hearing-impaired frequency and the group who trained other frequencies. Auditory Discrimination training significantly improved tinnitus handicap compared to a waiting list group. Those patients who trained frequencies one octave below the tinnitus pitch had better outcome than those who performed the ADT with frequencies similar to the tinnitus pitch (P = 0.035)
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Auditory Discrimination therapy (ADT) for tinnitus management
Progress in brain research, 2007Co-Authors: Carlos Herraiz, I. Diges, Pedro CoboAbstract:Auditory Discrimination training (ADT) designs a procedure to increase cortical areas responding to trained frequencies (damaged cochlear areas with cortical misrepresentation) and to shrink the neighboring over-represented ones (tinnitus pitch). In a prospective descriptive study of 27 patients with high frequency tinnitus, the severity of the tinnitus was measured using a visual analog scale (VAS) and the tinnitus handicap inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day during one month. Discontinuous 4 kHz pure tones were mixed randomly with short broadband noise sounds through an MP3 system. After the treatment mean VAS scores were reduced from 5.2 to 4.5 (p=0.000) and the THI decreased from 26.2% to 21.3% (p=0.000). Forty percent of the patients had improvement in tinnitus perception (RESP). Comparing the ADT group with a control group showed statistically significant improvement of their tinnitus as assessed by RESP, VAS, and THI.
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Auditory Discrimination therapy (ADT) for tinnitus managment: preliminary results
Acta oto-laryngologica. Supplementum, 2006Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, Guillermo Plaza, J. M. AparicioAbstract:This clinical assay has demonstrated the efficacy of Auditory Discrimination therapy (ADT) in tinnitus management compared with a waiting-list group. In all, 43% of the ADT patients improved their tinnitus, and its intensity together with its handicap were statistically decreased (EMB rating: B-2). To describe the effect of sound Discrimination training on tinnitus. ADT designs a procedure to increase the cortical representation of trained frequencies (damaged cochlear areas with a secondary reduction of cortical stimulation) and to shrink the neighbouring over-represented ones (corresponding to tinnitus pitch). This prospective descriptive study included 14 patients with high frequency matched tinnitus. Tinnitus severity was measured according to a visual analogue scale (VAS) and the Tinnitus Handicap Inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day for 1 month. Discontinuous 8 kHz pure tones were randomly mixed with 500 ms 'white noise' sounds through a MP3 system. ADT group results were compared with a waiting-list group (n=21). In all, 43% of our patients had improvement in their tinnitus. A significant improvement in VAS (p=0.004) and THI mean scores was achieved (p=0.038). Statistical differences between ADT and the waiting-list group have been proved, considering patients' self-evaluations (p=0.043) and VAS scores (p=0.004). A non-significant reduction of THI was achieved (p=0.113).
Carlos Herraiz - One of the best experts on this subject based on the ideXlab platform.
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Auditory Discrimination training for tinnitus treatment the effect of different paradigms
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, J. M. Aparicio, A ToledanoAbstract:Acoustic deprivation, i.e. hearing loss, is responsible for a cascade of processes resulting in reorganisation of the cortex. Tinnitus mechanisms are explained by synchronization of the neural spontaneous activity and might be related to cortical re-mapping. Auditory Discrimination training (ADT) has demonstrated in both animals and humans to induce tonotopical changes in the Auditory pathways through neural plasticity. We hypothesize that ADT could have some effect on tinnitus perception. The objective of this study is to compare the effect on tinnitus following two paradigms of ADT. Only patients from 20 to 60 years of age were recruited. Inclusion criteria were pure tone tinnitus of mild or moderate handicap according to the Tinnitus Handicap Inventory score (<56). ADT patients were randomized in two groups: SAME (ADT in the same frequency of tinnitus pitch, 20 patients) and NONSAME (ADT in the frequency one-octave below tinnitus pitch, 21 patients). Groups of pair of tones (70% standard tones ST, 30% deviant tones ST + 0.1–0.5 kHz) were randomly mixed for 20 min/day during 1 month. Patient had to mark when the two sounds of the pair were similar or different. Control group included 26 patients from the waiting list (WLG). Patients were also divided according to the trained frequency and the deepest hearing-impaired frequency. Outcome parameters were set up according to the answer to the question “is your tinnitus better, same, or worse with the treatment?” (RESP), the tinnitus handicap inventory (THI) and the visual analogue scale from 1 to 10 on tinnitus intensity (VAS). Tinnitus improved in 42.2% of the patients (RESP). VAS and THI scores were reduced but only THI differences were statistically significant (P = 0.003). ADT patients improved significantly compared with WLG in RESP and THI scores (P < 0.01). Training frequencies one-octave below the tinnitus pitch (NONSAME) decreased significantly THI scores compared with patients trained frequencies similar to tinnitus pitch (SAME, P = 0.035). RESP and VAS scores decreased more in NONSAME group though differences were not significant. We did not find any differences when comparing the group training the deepest hearing-impaired frequency and the group who trained other frequencies. Auditory Discrimination training significantly improved tinnitus handicap compared to a waiting list group. Those patients who trained frequencies one octave below the tinnitus pitch had better outcome than those who performed the ADT with frequencies similar to the tinnitus pitch (P = 0.035)
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Auditory Discrimination therapy (ADT) for tinnitus management
Progress in brain research, 2007Co-Authors: Carlos Herraiz, I. Diges, Pedro CoboAbstract:Auditory Discrimination training (ADT) designs a procedure to increase cortical areas responding to trained frequencies (damaged cochlear areas with cortical misrepresentation) and to shrink the neighboring over-represented ones (tinnitus pitch). In a prospective descriptive study of 27 patients with high frequency tinnitus, the severity of the tinnitus was measured using a visual analog scale (VAS) and the tinnitus handicap inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day during one month. Discontinuous 4 kHz pure tones were mixed randomly with short broadband noise sounds through an MP3 system. After the treatment mean VAS scores were reduced from 5.2 to 4.5 (p=0.000) and the THI decreased from 26.2% to 21.3% (p=0.000). Forty percent of the patients had improvement in tinnitus perception (RESP). Comparing the ADT group with a control group showed statistically significant improvement of their tinnitus as assessed by RESP, VAS, and THI.
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Auditory Discrimination therapy (ADT) for tinnitus managment: preliminary results
Acta oto-laryngologica. Supplementum, 2006Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, Guillermo Plaza, J. M. AparicioAbstract:This clinical assay has demonstrated the efficacy of Auditory Discrimination therapy (ADT) in tinnitus management compared with a waiting-list group. In all, 43% of the ADT patients improved their tinnitus, and its intensity together with its handicap were statistically decreased (EMB rating: B-2). To describe the effect of sound Discrimination training on tinnitus. ADT designs a procedure to increase the cortical representation of trained frequencies (damaged cochlear areas with a secondary reduction of cortical stimulation) and to shrink the neighbouring over-represented ones (corresponding to tinnitus pitch). This prospective descriptive study included 14 patients with high frequency matched tinnitus. Tinnitus severity was measured according to a visual analogue scale (VAS) and the Tinnitus Handicap Inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day for 1 month. Discontinuous 8 kHz pure tones were randomly mixed with 500 ms 'white noise' sounds through a MP3 system. ADT group results were compared with a waiting-list group (n=21). In all, 43% of our patients had improvement in their tinnitus. A significant improvement in VAS (p=0.004) and THI mean scores was achieved (p=0.038). Statistical differences between ADT and the waiting-list group have been proved, considering patients' self-evaluations (p=0.043) and VAS scores (p=0.004). A non-significant reduction of THI was achieved (p=0.113).
Risto Näätänen - One of the best experts on this subject based on the ideXlab platform.
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comprehensive Auditory Discrimination profiles recorded with a fast parametric musical multi feature mismatch negativity paradigm
Clinical Neurophysiology, 2016Co-Authors: Peter Vuust, Risto Näätänen, Lari Liikala, Pauli Brattico, Elvira BratticoAbstract:Abstract Objective Mismatch negativity (MMN), a component of the Auditory event-related potential (ERP) in response to Auditory-expectancy violation, is sensitive to central Auditory processing deficits associated with several clinical conditions and to Auditory skills deriving from musical expertise. This sensitivity is more evident for stimuli integrated in complex sound contexts. This study tested whether increasing magnitudes of deviation (levels) entail increasing MMN amplitude (or decreasing latency), aiming to create a balanced version of the musical multi-feature paradigm towards measurement of extensive Auditory Discrimination profiles in Auditory expertise or deficits. Methods Using electroencephalography, we measured MMNs in healthy young adults to six types of sound feature change (pitch, timbre, location, intensity, slide and rhythm) at three different magnitudes of deviation, embedded in a music-sounding context. We also behaviourally assessed the individual musical aptitude using the Musical Ear Test (MET). Results 16 of 18 sound feature changes elicited significant MMNs. For pitch, intensity, location, and slide, the MMN amplitude increased with increasing magnitude of feature change. We observed a ceiling effect for rhythm, and a floor effect for timbre. The slide MMN amplitude correlated positively with MET melody score and negatively with MET rhythm score. Conclusions This novel paradigm provides an extensive, objective measure of Auditory Discrimination profile for different sound features embedded in a complex sound context. Significance The paradigm can be adopted to study the neurophysiology of individuals with music processing difficulties or with special musical skills, and may be a useful tool for investigating development, plasticity, and deficits of Auditory processing.
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measurement of extensive Auditory Discrimination profiles using the mismatch negativity mmn of the Auditory event related potential erp
Clinical Neurophysiology, 2007Co-Authors: Satu Pakarinen, Minna Huotilainen, Rika Takegata, Teemu Rinne, Risto NäätänenAbstract:Abstract Objective Mismatch negativity (MMN), a change-specific component of the Auditory event-related potential (ERP), is sensitive to deficits in central Auditory processing associated with many clinical conditions. The aim of this study was to obtain a comprehensive multi-dimensional profile of central Auditory processing by extending the recently developed fast multi-feature MMN paradigm [Naatanen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol 2004;115:140–144]. Methods MMN responses to changes in sound duration, frequency, intensity, and perceived sound-source location at six different magnitudes of deviation were recorded from healthy young adults by using the multi-feature MMN paradigm. In addition, behavioural Discrimination accuracy and speed were measured to examine the relationship between MMN and behavioural performance. Results All the 24 sound changes elicited significant MMNs. MMN amplitude increased and latency decreased with increasing magnitude of sound change. Furthermore, the MMN amplitude and latency predicted the subjects’ accuracy and speed in detecting these deviations. Conclusions This new paradigm provides an extensive Auditory Discrimination profile for several Auditory attributes at different deviation magnitudes in a minimal recording time. Significance The Auditory Discrimination profiles can offer a comprehensive view of the development, plasticity, and deficits of central Auditory processing.
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Auditory Discrimination After Left-Hemisphere Stroke: A Mismatch Negativity Follow-Up Study
Stroke, 2003Co-Authors: Titta-maria Ilvonen, Teija Kujala, Anita Kiesiläinen, Oili Salonen, Hesham Kozou, Eero Pekkonen, Risto O. Roine, Markku Kaste, Risto NäätänenAbstract:We sought to determine the recovery of cortical Auditory Discrimination in aphasic, left-hemisphere-stroke patients by using an electrophysiological response called mismatch negativity (MMN) and speech-comprehension tests. MMN in 8 left-hemisphere stroke patients was recorded in response to duration and frequency changes in a repetitive, harmonically rich tone 4 and 10 days and again 3 and 6 months after their first unilateral stroke. Eight age-matched, healthy persons served as control subjects. At 4 days after stroke onset, patients' sound Discrimination was impaired in their left hemisphere, as suggested by attenuated MMNs, especially to right-ear stimuli. At 3 months after stroke, however, MMN to the right-ear duration change had significantly increased and was of normal size. A significant change for the frequency MMN was found for left-ear stimuli between 3 and 6 months after stroke. During the follow-up period, progressive improvement in speech-comprehension tests was also observed. Furthermore, there was a significant correlation between the change in the duration MMN amplitude and the Boston Diagnostic Aphasia Examination speech-comprehension test from 10 days to 3 months after stroke. These results suggest that the MMN can be used as an index of the recovery of Auditory Discrimination.
I. Diges - One of the best experts on this subject based on the ideXlab platform.
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Auditory Discrimination training for tinnitus treatment the effect of different paradigms
European Archives of Oto-rhino-laryngology, 2010Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, J. M. Aparicio, A ToledanoAbstract:Acoustic deprivation, i.e. hearing loss, is responsible for a cascade of processes resulting in reorganisation of the cortex. Tinnitus mechanisms are explained by synchronization of the neural spontaneous activity and might be related to cortical re-mapping. Auditory Discrimination training (ADT) has demonstrated in both animals and humans to induce tonotopical changes in the Auditory pathways through neural plasticity. We hypothesize that ADT could have some effect on tinnitus perception. The objective of this study is to compare the effect on tinnitus following two paradigms of ADT. Only patients from 20 to 60 years of age were recruited. Inclusion criteria were pure tone tinnitus of mild or moderate handicap according to the Tinnitus Handicap Inventory score (<56). ADT patients were randomized in two groups: SAME (ADT in the same frequency of tinnitus pitch, 20 patients) and NONSAME (ADT in the frequency one-octave below tinnitus pitch, 21 patients). Groups of pair of tones (70% standard tones ST, 30% deviant tones ST + 0.1–0.5 kHz) were randomly mixed for 20 min/day during 1 month. Patient had to mark when the two sounds of the pair were similar or different. Control group included 26 patients from the waiting list (WLG). Patients were also divided according to the trained frequency and the deepest hearing-impaired frequency. Outcome parameters were set up according to the answer to the question “is your tinnitus better, same, or worse with the treatment?” (RESP), the tinnitus handicap inventory (THI) and the visual analogue scale from 1 to 10 on tinnitus intensity (VAS). Tinnitus improved in 42.2% of the patients (RESP). VAS and THI scores were reduced but only THI differences were statistically significant (P = 0.003). ADT patients improved significantly compared with WLG in RESP and THI scores (P < 0.01). Training frequencies one-octave below the tinnitus pitch (NONSAME) decreased significantly THI scores compared with patients trained frequencies similar to tinnitus pitch (SAME, P = 0.035). RESP and VAS scores decreased more in NONSAME group though differences were not significant. We did not find any differences when comparing the group training the deepest hearing-impaired frequency and the group who trained other frequencies. Auditory Discrimination training significantly improved tinnitus handicap compared to a waiting list group. Those patients who trained frequencies one octave below the tinnitus pitch had better outcome than those who performed the ADT with frequencies similar to the tinnitus pitch (P = 0.035)
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Cortical reorganisation and tinnitus: principles of Auditory Discrimination training for tinnitus management
European Archives of Oto-Rhino-Laryngology, 2008Co-Authors: C. Herraiz, I. Diges, P. Cobo, J. M. AparicioAbstract:Scientific evidence has proved reorganisation processes in the Auditory cortex after sensorineural hearing loss and overstimulation of certain tonotopic cortical areas, as we see in Auditory conditioning techniques. Acoustic rehabilitation reduces the impact of these reorganisation changes. Recent theories explain tinnitus mechanisms as a negative consequence of neural plasticity in the central nervous system after a peripheral aggression. Auditory Discrimination training (ADT) could partially reverse the wrong changes in tonotopic representation and improve tinnitus. We discuss different studies and their efficacy on tinnitus perception and annoyance. Indications, method, dose and sound strategy need to be implemented.
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Auditory Discrimination therapy (ADT) for tinnitus management
Progress in brain research, 2007Co-Authors: Carlos Herraiz, I. Diges, Pedro CoboAbstract:Auditory Discrimination training (ADT) designs a procedure to increase cortical areas responding to trained frequencies (damaged cochlear areas with cortical misrepresentation) and to shrink the neighboring over-represented ones (tinnitus pitch). In a prospective descriptive study of 27 patients with high frequency tinnitus, the severity of the tinnitus was measured using a visual analog scale (VAS) and the tinnitus handicap inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day during one month. Discontinuous 4 kHz pure tones were mixed randomly with short broadband noise sounds through an MP3 system. After the treatment mean VAS scores were reduced from 5.2 to 4.5 (p=0.000) and the THI decreased from 26.2% to 21.3% (p=0.000). Forty percent of the patients had improvement in tinnitus perception (RESP). Comparing the ADT group with a control group showed statistically significant improvement of their tinnitus as assessed by RESP, VAS, and THI.
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Auditory Discrimination therapy (ADT) for tinnitus managment: preliminary results
Acta oto-laryngologica. Supplementum, 2006Co-Authors: Carlos Herraiz, I. Diges, Pedro Cobo, Guillermo Plaza, J. M. AparicioAbstract:This clinical assay has demonstrated the efficacy of Auditory Discrimination therapy (ADT) in tinnitus management compared with a waiting-list group. In all, 43% of the ADT patients improved their tinnitus, and its intensity together with its handicap were statistically decreased (EMB rating: B-2). To describe the effect of sound Discrimination training on tinnitus. ADT designs a procedure to increase the cortical representation of trained frequencies (damaged cochlear areas with a secondary reduction of cortical stimulation) and to shrink the neighbouring over-represented ones (corresponding to tinnitus pitch). This prospective descriptive study included 14 patients with high frequency matched tinnitus. Tinnitus severity was measured according to a visual analogue scale (VAS) and the Tinnitus Handicap Inventory (THI). Patients performed a 10-min Auditory Discrimination task twice a day for 1 month. Discontinuous 8 kHz pure tones were randomly mixed with 500 ms 'white noise' sounds through a MP3 system. ADT group results were compared with a waiting-list group (n=21). In all, 43% of our patients had improvement in their tinnitus. A significant improvement in VAS (p=0.004) and THI mean scores was achieved (p=0.038). Statistical differences between ADT and the waiting-list group have been proved, considering patients' self-evaluations (p=0.043) and VAS scores (p=0.004). A non-significant reduction of THI was achieved (p=0.113).
Minna Huotilainen - One of the best experts on this subject based on the ideXlab platform.
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linguistic multifeature mmn paradigm for extensive recording of Auditory Discrimination profiles
Psychophysiology, 2011Co-Authors: Teija Kujala, Eino Partanen, Martti Vainio, Minna HuotilainenAbstract:We studied whether a multifeature mismatch negativity (MMN) paradigm using naturally produced speech stimuli is feasible for studies of Auditory Discrimination accuracy of adult participants. A naturally produced trisyllabic pseudoword was used in the paradigm, and MMNs were recorded to changes that were acoustic (changes in fundamental frequency or intensity) or potentially phonological (changes in vowel identity or vowel duration). All the different changes were presented in three different word segments (initial, middle, or final syllable). All changes elicited an MMN response, but the vowel duration change elicited a different response pattern than the other deviant types. Changes in vowel duration and identity also had an effect on MMN lateralization. Our results show that assessing speech sound Discrimination of several features in word context is possible in a short recording time (30 min) with the multifeature paradigm.
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measurement of extensive Auditory Discrimination profiles using the mismatch negativity mmn of the Auditory event related potential erp
Clinical Neurophysiology, 2007Co-Authors: Satu Pakarinen, Minna Huotilainen, Rika Takegata, Teemu Rinne, Risto NäätänenAbstract:Abstract Objective Mismatch negativity (MMN), a change-specific component of the Auditory event-related potential (ERP), is sensitive to deficits in central Auditory processing associated with many clinical conditions. The aim of this study was to obtain a comprehensive multi-dimensional profile of central Auditory processing by extending the recently developed fast multi-feature MMN paradigm [Naatanen R, Pakarinen S, Rinne T, Takegata R. The mismatch negativity (MMN): towards the optimal paradigm. Clin Neurophysiol 2004;115:140–144]. Methods MMN responses to changes in sound duration, frequency, intensity, and perceived sound-source location at six different magnitudes of deviation were recorded from healthy young adults by using the multi-feature MMN paradigm. In addition, behavioural Discrimination accuracy and speed were measured to examine the relationship between MMN and behavioural performance. Results All the 24 sound changes elicited significant MMNs. MMN amplitude increased and latency decreased with increasing magnitude of sound change. Furthermore, the MMN amplitude and latency predicted the subjects’ accuracy and speed in detecting these deviations. Conclusions This new paradigm provides an extensive Auditory Discrimination profile for several Auditory attributes at different deviation magnitudes in a minimal recording time. Significance The Auditory Discrimination profiles can offer a comprehensive view of the development, plasticity, and deficits of central Auditory processing.