The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform
Eli Estey - One of the best experts on this subject based on the ideXlab platform.
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The prognostic significance of Auer Rods in myelodysplasia
British journal of haematology, 1993Co-Authors: John F. Seymour, Eli EsteyAbstract:The category of refractory anaemia with excess blasts in transformation (RAEBt) of the French-American-British (FAB) classification system comprises a heterogeneous group of patients: those with any combination of 5% or more blood blast cells, more than 20% but no more than 30% marrow blast cells, or the presence of Auer Rods and 30% or less marrow blast cells. To determine the prognostic significance of Auer Rods in RAEBt, we classified the 208 patients with RAEBt seen between 1973 and 1992 as (1) those having RAEBt solely on the basis of Auer Rods (RAEBta, n = 29), (2) those meeting blood or marrow blast criteria for RAEBt and also having Auer Rods (RAEBtpos, n = 40) or (3) those meeting blood or marrow blast criteria for RAEBt without having Auer Rods (RAEBtneg, n = 139). The RAEBta group had a higher survival probability than either of the other two groups. Within RAEBta, those patients who, without Auer Rods, would be considered RAEB by the FAB system (n = 19) had a higher probability of survival than patients with RAEB as conventionally defined. Furthermore, patients with RAEBtpos were more likely to live longer than those with RAEBtneg. The RAEBta, RAEBtpos and RAEBtneg groups were similar with regard to the usual haematologic parameters. However, patients with Auer Rods were more likely to have a normal karyotype and less likely to have prognostically unfavourable cytogenetic abnormalities. When analysis was performed within cytogenetic groups, the favourable prognostic impact of Auer Rods was still evident. Similarly, the favourable prognostic significance of Auer Rods was discernible both among patients who did not receive intensive therapy and those who received induction chemotherapy. The complete remission rate in Auer Rod positive patients was 77%, compared to 27% in those without Auer Rods. There were no differences in remission duration. Our results suggest that: (1) patients with Auer Rods without blood or bone marrow blast criteria for RAEBt should not be grouped with those patients with such criteria, and (2) patients with Auer Rods and other criteria for RAEBt have a higher complete remission rate following induction therapy of the type frequently reserved for patients with acute myeloid leukaemia.
John F. Seymour - One of the best experts on this subject based on the ideXlab platform.
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The prognostic significance of Auer Rods in myelodysplasia
British journal of haematology, 1993Co-Authors: John F. Seymour, Eli EsteyAbstract:The category of refractory anaemia with excess blasts in transformation (RAEBt) of the French-American-British (FAB) classification system comprises a heterogeneous group of patients: those with any combination of 5% or more blood blast cells, more than 20% but no more than 30% marrow blast cells, or the presence of Auer Rods and 30% or less marrow blast cells. To determine the prognostic significance of Auer Rods in RAEBt, we classified the 208 patients with RAEBt seen between 1973 and 1992 as (1) those having RAEBt solely on the basis of Auer Rods (RAEBta, n = 29), (2) those meeting blood or marrow blast criteria for RAEBt and also having Auer Rods (RAEBtpos, n = 40) or (3) those meeting blood or marrow blast criteria for RAEBt without having Auer Rods (RAEBtneg, n = 139). The RAEBta group had a higher survival probability than either of the other two groups. Within RAEBta, those patients who, without Auer Rods, would be considered RAEB by the FAB system (n = 19) had a higher probability of survival than patients with RAEB as conventionally defined. Furthermore, patients with RAEBtpos were more likely to live longer than those with RAEBtneg. The RAEBta, RAEBtpos and RAEBtneg groups were similar with regard to the usual haematologic parameters. However, patients with Auer Rods were more likely to have a normal karyotype and less likely to have prognostically unfavourable cytogenetic abnormalities. When analysis was performed within cytogenetic groups, the favourable prognostic impact of Auer Rods was still evident. Similarly, the favourable prognostic significance of Auer Rods was discernible both among patients who did not receive intensive therapy and those who received induction chemotherapy. The complete remission rate in Auer Rod positive patients was 77%, compared to 27% in those without Auer Rods. There were no differences in remission duration. Our results suggest that: (1) patients with Auer Rods without blood or bone marrow blast criteria for RAEBt should not be grouped with those patients with such criteria, and (2) patients with Auer Rods and other criteria for RAEBt have a higher complete remission rate following induction therapy of the type frequently reserved for patients with acute myeloid leukaemia.
Marc Zandecki - One of the best experts on this subject based on the ideXlab platform.
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Is there any significance for intracellular crystals in plasma cells from patients with monoclonal gammopathies
European journal of haematology, 2001Co-Authors: J Gardais, F Geneviève, C Foussard, V. Delisle, Marc ZandeckiAbstract:Several plasma cells morphological changes have been described in monoclonal gammopathies, including intracytoplasmic crystals. We report one case of indolent kappa-chain multiple myeloma with renal insufficiency, featuring plasma cells with Auer-Rod-like intracytoplasmic inclusions. The relationship between such aberrations and those found in multiple-myeloma-associated adult Fanconi syndrome is discussed. The significance of intracellular storage and crystallisation of immunoglobulin within plasma cells remains partially unknown.
Frank R. Dunphy - One of the best experts on this subject based on the ideXlab platform.
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Auer Rod-like inclusions in adult common acute lymphoblastic leukemia.
Human Pathology, 1994Co-Authors: Cherie H. Dunphy, David Chung, Frank R. DunphyAbstract:We report a case of adult common acute lymphoblastic leukemia, defined by enzyme histochemistry and immunophenotypic analysis, which had Rod-shaped cytoplasmic inclusions that on Wright's-stained peripheral blood smear resembled Auer Rods. Electron microscopic analysis of a buffy coat preparation revealed that the inclusions were not characteristic of Auer Rods, but rather that they were composed of concentric lamellar structures with no limiting membrane and were closely associated with the nuclear membrane. Therefore, the presence of Auer Rod-like inclusions in blasts on a Wright's-stained peripheral blood smear does not preclude a diagnosis of acute lymphoblastic leukemia.
Jan Hastka - One of the best experts on this subject based on the ideXlab platform.
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Auer Rod-like inclusions in multiple myeloma.
Annals of hematology, 2002Co-Authors: Georgia Metzgeroth, W. Back, O. Maywald, Michael Schatz, A. Willer, Ruediger Hehlmann, Jan HastkaAbstract:We report a case of IgA multiple myeloma, in which the plasma cells showed multiple azurophilic, Auer Rod-like intracytoplasmic inclusions in May-Grunwald-Giemsa-stained marrow smears. Cytochemical stainings revealed a strong α-N-esterase activity of these inclusions, whereas the reactions for peroxidase, Sudan black, chloroacetate esterase, and PAS were negative. Immunostaining verified IgA-kappa inside the plasma cells. The inclusions, however, were negative. Amyloid and lysozyme were also not detectable. Electron microscopy showed Auer Rod-like inclusions with a smooth surface in the neighborhood of a well-developed rough endoplasmic reticulum, but with no direct relation to it. The inclusions showed a fine lamellar substructure, and the periodicity of the filamentous striations was about 10 nm, comparable with the substructure of typical Auer Rods. Our findings suggest that the azurophilic inclusions in multiple myeloma are Auer Rod-related structures, which likewise consist of active lysosomal enzymes. In contrast to the Auer Rods in acute myeloblastic leukemia (AML), however, the inclusions in multiple myeloma consist of typical plasma cell enzymes.