The Experts below are selected from a list of 9309 Experts worldwide ranked by ideXlab platform
Sean P Gorman - One of the best experts on this subject based on the ideXlab platform.
-
characterization of crosslinking effects on the physicochemical and drug diffusional properties of cationic hydrogels designed as bioactive urological biomaterials
Journal of Pharmacy and Pharmacology, 2005Co-Authors: David S Jones, Gavin Andrews, Sean P GormanAbstract:: This study examined the effects of concentration and type of crosslinker (tetraethyleneglycol diacrylate, TEGDA; diethyleneglycol dimethacrylate, DEGDMA; and polyethyleneglycol dimethacrylate, PEGDMA) on the mechanical and drug diffusional properties of hydrogels that had been selected as candidate coatings for bioactive medical devices. Hydrogels (dimethylaminoethylmethacrylate-co-vinylpyrrolidone; 1:1) were prepared by free radical polymerization and characterized using tensile analysis, dynamic contact angle analysis and analysis of swelling at pH 6.0. The release of fusidic acid and chlorhexidine was evaluated using buffered Medium at pH 6.0 and, in addition, using dissolution Medium that had been buffered to pH 9 in the presence and absence of elevated concentrations of calcium, representative of urinary encrustation. Crosslinker concentration, but not type, affected the advancing and receding contact angles. Conversely, both crosslinker type and concentration affected the mechanical and swelling properties of the hydrogels. Maximum swelling and elongation at break were associated with the PEGDMA-crosslinked hydrogels whereas TEGDA-crosslinked hydrogels exhibited the maximum ultimate tensile strength and Young's modulus. Drug release from all systems occurred by diffusion. The mass of chlorhexidine and fusidic acid released was dependent on crosslinker type and concentration, with hydrogels crosslinked with PEGDMA offering the greatest mass of drug released at each sampling period. The mass of fusidic acid but not chlorhexidine released at pH 9.0 in a calcium Augmented Medium was lower than that released in the same Medium devoid of elevated calcium, due to the formation of the poorly soluble calcium salt. In conclusion, this study has uniquely examined the effects of crosslinker type and concentration on physicochemical and drug release properties essential to the clinical and non-clinical performance of bioactive hydrogels for medical device application.
David S Jones - One of the best experts on this subject based on the ideXlab platform.
-
characterization of crosslinking effects on the physicochemical and drug diffusional properties of cationic hydrogels designed as bioactive urological biomaterials
Journal of Pharmacy and Pharmacology, 2005Co-Authors: David S Jones, Gavin Andrews, Sean P GormanAbstract:: This study examined the effects of concentration and type of crosslinker (tetraethyleneglycol diacrylate, TEGDA; diethyleneglycol dimethacrylate, DEGDMA; and polyethyleneglycol dimethacrylate, PEGDMA) on the mechanical and drug diffusional properties of hydrogels that had been selected as candidate coatings for bioactive medical devices. Hydrogels (dimethylaminoethylmethacrylate-co-vinylpyrrolidone; 1:1) were prepared by free radical polymerization and characterized using tensile analysis, dynamic contact angle analysis and analysis of swelling at pH 6.0. The release of fusidic acid and chlorhexidine was evaluated using buffered Medium at pH 6.0 and, in addition, using dissolution Medium that had been buffered to pH 9 in the presence and absence of elevated concentrations of calcium, representative of urinary encrustation. Crosslinker concentration, but not type, affected the advancing and receding contact angles. Conversely, both crosslinker type and concentration affected the mechanical and swelling properties of the hydrogels. Maximum swelling and elongation at break were associated with the PEGDMA-crosslinked hydrogels whereas TEGDA-crosslinked hydrogels exhibited the maximum ultimate tensile strength and Young's modulus. Drug release from all systems occurred by diffusion. The mass of chlorhexidine and fusidic acid released was dependent on crosslinker type and concentration, with hydrogels crosslinked with PEGDMA offering the greatest mass of drug released at each sampling period. The mass of fusidic acid but not chlorhexidine released at pH 9.0 in a calcium Augmented Medium was lower than that released in the same Medium devoid of elevated calcium, due to the formation of the poorly soluble calcium salt. In conclusion, this study has uniquely examined the effects of crosslinker type and concentration on physicochemical and drug release properties essential to the clinical and non-clinical performance of bioactive hydrogels for medical device application.
Gavin Andrews - One of the best experts on this subject based on the ideXlab platform.
-
characterization of crosslinking effects on the physicochemical and drug diffusional properties of cationic hydrogels designed as bioactive urological biomaterials
Journal of Pharmacy and Pharmacology, 2005Co-Authors: David S Jones, Gavin Andrews, Sean P GormanAbstract:: This study examined the effects of concentration and type of crosslinker (tetraethyleneglycol diacrylate, TEGDA; diethyleneglycol dimethacrylate, DEGDMA; and polyethyleneglycol dimethacrylate, PEGDMA) on the mechanical and drug diffusional properties of hydrogels that had been selected as candidate coatings for bioactive medical devices. Hydrogels (dimethylaminoethylmethacrylate-co-vinylpyrrolidone; 1:1) were prepared by free radical polymerization and characterized using tensile analysis, dynamic contact angle analysis and analysis of swelling at pH 6.0. The release of fusidic acid and chlorhexidine was evaluated using buffered Medium at pH 6.0 and, in addition, using dissolution Medium that had been buffered to pH 9 in the presence and absence of elevated concentrations of calcium, representative of urinary encrustation. Crosslinker concentration, but not type, affected the advancing and receding contact angles. Conversely, both crosslinker type and concentration affected the mechanical and swelling properties of the hydrogels. Maximum swelling and elongation at break were associated with the PEGDMA-crosslinked hydrogels whereas TEGDA-crosslinked hydrogels exhibited the maximum ultimate tensile strength and Young's modulus. Drug release from all systems occurred by diffusion. The mass of chlorhexidine and fusidic acid released was dependent on crosslinker type and concentration, with hydrogels crosslinked with PEGDMA offering the greatest mass of drug released at each sampling period. The mass of fusidic acid but not chlorhexidine released at pH 9.0 in a calcium Augmented Medium was lower than that released in the same Medium devoid of elevated calcium, due to the formation of the poorly soluble calcium salt. In conclusion, this study has uniquely examined the effects of crosslinker type and concentration on physicochemical and drug release properties essential to the clinical and non-clinical performance of bioactive hydrogels for medical device application.
Nima Izadyar - One of the best experts on this subject based on the ideXlab platform.
-
An empirical analysis on photovoltaic thermal system with fin design by forced air circulation
Journal of Mechanical Science and Technology, 2017Co-Authors: Juwel Chandra Mojumder, Hwai Chyuan Ong, Wen Tong Chong, Kin Yuen Leong, Nima IzadyarAbstract:Air cooling photovoltaic can be configured as a method to improve the performance of Photovoltaic thermal (PV/T) system. In this article, a series of aluminum rectangular fins were considered as an important Augmented Medium of heat conduction and convection. The efficiency of the installed fins was obtained by analysis of the general algebraic modeling system, which was validated for different fin heights and thicknesses. Fins were incorporated in reducing the cell temperature that obtained a higher outlet temperature of PV/T with time. It was observed that the collector outlet air temperatures, PV cell temperatures for different air flows and solar radiations under the different fin geometries in an indoor experimental condition. The output PV/T power was compared between ‘with fin’ and ‘without fin’ condition. The optimum interrupted length and height of a fin makes a compact relationship for the thermal and electrical performance. Results showed that the heat gain has been increased with the increasing of the solar irradiance at a constant air velocity. The collector heat gain value was found about 159.8W at 700 W/m^2 solar radiation with four fins design.
Juwel Chandra Mojumder - One of the best experts on this subject based on the ideXlab platform.
-
An empirical analysis on photovoltaic thermal system with fin design by forced air circulation
Journal of Mechanical Science and Technology, 2017Co-Authors: Juwel Chandra Mojumder, Hwai Chyuan Ong, Wen Tong Chong, Kin Yuen Leong, Nima IzadyarAbstract:Air cooling photovoltaic can be configured as a method to improve the performance of Photovoltaic thermal (PV/T) system. In this article, a series of aluminum rectangular fins were considered as an important Augmented Medium of heat conduction and convection. The efficiency of the installed fins was obtained by analysis of the general algebraic modeling system, which was validated for different fin heights and thicknesses. Fins were incorporated in reducing the cell temperature that obtained a higher outlet temperature of PV/T with time. It was observed that the collector outlet air temperatures, PV cell temperatures for different air flows and solar radiations under the different fin geometries in an indoor experimental condition. The output PV/T power was compared between ‘with fin’ and ‘without fin’ condition. The optimum interrupted length and height of a fin makes a compact relationship for the thermal and electrical performance. Results showed that the heat gain has been increased with the increasing of the solar irradiance at a constant air velocity. The collector heat gain value was found about 159.8W at 700 W/m^2 solar radiation with four fins design.
