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Authoritative Source

The Experts below are selected from a list of 216 Experts worldwide ranked by ideXlab platform

Joel E. Richardson – 1st expert on this subject based on the ideXlab platform

  • the mouse genome database mgd facilitating mouse as a model for human biology and disease
    Nucleic Acids Research, 2015
    Co-Authors: J. T. Eppig, Judith A. Blake, Carol J. Bult, James A. Kadin, Joel E. Richardson

    Abstract:

    The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central reSource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the Authoritative Source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD reSources are freely available to the scientific community.

  • The Mouse Genome Database (MGD): Comprehensive reSource for genetics and genomics of the laboratory mouse
    Nucleic Acids Research, 2012
    Co-Authors: J. T. Eppig, Judith A. Blake, Carol J. Bult, James A. Kadin, Joel E. Richardson, M. T. Airey, Aris Anagnostopoulos, R. Babiuk, R. M. Baldarelli, J. S. Beal

    Abstract:

    The Mouse Genome Database (MGD, http://www.informatics.jax.org) is the international community reSource for integrated genetic, genomic and biological data about the laboratory mouse. Data in MGD are obtained through loads from major data providers and experimental consortia, electronic submissions from laboratories and from the biomedical literature. MGD maintains a comprehensive, unified, non-redundant catalog of mouse genome features generated by distilling gene predictions from NCBI, Ensembl and VEGA. MGD serves as the Authoritative Source for the nomenclature of mouse genes, mutations, alleles and strains. MGD is the primary Source for evidence-supported functional annotations for mouse genes and gene products using the Gene Ontology (GO). MGD provides full annotation of phenotypes and human disease associations for mouse models (genotypes) using terms from the Mammalian Phenotype Ontology and disease names from the Online Mendelian Inheritance in Man (OMIM) reSource. MGD is freely accessible online through our website, where users can browse and search interactively, access data in bulk using Batch Query or BioMart, download data files or use our web services Application Programming Interface (API). Improvements to MGD include expanded genome feature classifications, inclusion of new mutant allele sets and phenotype associations and extensions of GO to include new relationships and a new stream of annotations via phylogenetic-based approaches.

J. T. Eppig – 2nd expert on this subject based on the ideXlab platform

  • the mouse genome database mgd facilitating mouse as a model for human biology and disease
    Nucleic Acids Research, 2015
    Co-Authors: J. T. Eppig, Judith A. Blake, Carol J. Bult, James A. Kadin, Joel E. Richardson

    Abstract:

    The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central reSource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the Authoritative Source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD reSources are freely available to the scientific community.

  • The Mouse Genome Database (MGD): Comprehensive reSource for genetics and genomics of the laboratory mouse
    Nucleic Acids Research, 2012
    Co-Authors: J. T. Eppig, Judith A. Blake, Carol J. Bult, James A. Kadin, Joel E. Richardson, M. T. Airey, Aris Anagnostopoulos, R. Babiuk, R. M. Baldarelli, J. S. Beal

    Abstract:

    The Mouse Genome Database (MGD, http://www.informatics.jax.org) is the international community reSource for integrated genetic, genomic and biological data about the laboratory mouse. Data in MGD are obtained through loads from major data providers and experimental consortia, electronic submissions from laboratories and from the biomedical literature. MGD maintains a comprehensive, unified, non-redundant catalog of mouse genome features generated by distilling gene predictions from NCBI, Ensembl and VEGA. MGD serves as the Authoritative Source for the nomenclature of mouse genes, mutations, alleles and strains. MGD is the primary Source for evidence-supported functional annotations for mouse genes and gene products using the Gene Ontology (GO). MGD provides full annotation of phenotypes and human disease associations for mouse models (genotypes) using terms from the Mammalian Phenotype Ontology and disease names from the Online Mendelian Inheritance in Man (OMIM) reSource. MGD is freely accessible online through our website, where users can browse and search interactively, access data in bulk using Batch Query or BioMart, download data files or use our web services Application Programming Interface (API). Improvements to MGD include expanded genome feature classifications, inclusion of new mutant allele sets and phenotype associations and extensions of GO to include new relationships and a new stream of annotations via phylogenetic-based approaches.

J. S. Beal – 3rd expert on this subject based on the ideXlab platform

  • The Mouse Genome Database (MGD): Comprehensive reSource for genetics and genomics of the laboratory mouse
    Nucleic Acids Research, 2012
    Co-Authors: J. T. Eppig, Judith A. Blake, Carol J. Bult, James A. Kadin, Joel E. Richardson, M. T. Airey, Aris Anagnostopoulos, R. Babiuk, R. M. Baldarelli, J. S. Beal

    Abstract:

    The Mouse Genome Database (MGD, http://www.informatics.jax.org) is the international community reSource for integrated genetic, genomic and biological data about the laboratory mouse. Data in MGD are obtained through loads from major data providers and experimental consortia, electronic submissions from laboratories and from the biomedical literature. MGD maintains a comprehensive, unified, non-redundant catalog of mouse genome features generated by distilling gene predictions from NCBI, Ensembl and VEGA. MGD serves as the Authoritative Source for the nomenclature of mouse genes, mutations, alleles and strains. MGD is the primary Source for evidence-supported functional annotations for mouse genes and gene products using the Gene Ontology (GO). MGD provides full annotation of phenotypes and human disease associations for mouse models (genotypes) using terms from the Mammalian Phenotype Ontology and disease names from the Online Mendelian Inheritance in Man (OMIM) reSource. MGD is freely accessible online through our website, where users can browse and search interactively, access data in bulk using Batch Query or BioMart, download data files or use our web services Application Programming Interface (API). Improvements to MGD include expanded genome feature classifications, inclusion of new mutant allele sets and phenotype associations and extensions of GO to include new relationships and a new stream of annotations via phylogenetic-based approaches.