The Experts below are selected from a list of 3633 Experts worldwide ranked by ideXlab platform
Dan J. Stein - One of the best experts on this subject based on the ideXlab platform.
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cortical hippocampal monoamines hpa axis changes and Aversive Behavior following stress and restress in an animal model of post traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
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Cortical/hippocampal monoamines, HPA-axis changes and Aversive Behavior following stress and restress in an animal model of post-traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
Brian H. Harvey - One of the best experts on this subject based on the ideXlab platform.
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cortical hippocampal monoamines hpa axis changes and Aversive Behavior following stress and restress in an animal model of post traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
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Cortical/hippocampal monoamines, HPA-axis changes and Aversive Behavior following stress and restress in an animal model of post-traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
Linda Brand - One of the best experts on this subject based on the ideXlab platform.
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cortical hippocampal monoamines hpa axis changes and Aversive Behavior following stress and restress in an animal model of post traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
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Cortical/hippocampal monoamines, HPA-axis changes and Aversive Behavior following stress and restress in an animal model of post-traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
Zakkiyya Jeeva - One of the best experts on this subject based on the ideXlab platform.
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cortical hippocampal monoamines hpa axis changes and Aversive Behavior following stress and restress in an animal model of post traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
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Cortical/hippocampal monoamines, HPA-axis changes and Aversive Behavior following stress and restress in an animal model of post-traumatic stress disorder
Physiology & Behavior, 2006Co-Authors: Brian H. Harvey, Linda Brand, Zakkiyya Jeeva, Dan J. SteinAbstract:Abstract Post-traumatic stress disorder (PTSD) is characterized by monoaminergic and hypothalamic–pituitary–adrenal (HPA)-axis abnormalities. Understanding monoamine-HPA-axis responses following stress and restress may provide a greater understanding of the neurobiology of PTSD and of its treatment. Hippocampal and frontal cortex serotonin, noradrenaline and dopamine, plasma corticosterone and Aversive Behavior were studied in rats on day 1 and day 7 post acute stress (AS = sequential restraint stress, swim stress and halothane exposure), and on day 1 and day 7 post restress (RS = swim stress). After AS, there was an early increase in both avoidant Behavior and corticosterone (1 h after stress), with subsequent normalisation (day 7), suggesting an adequate adaptive response to the stressor. However, restress (RS) evoked a significant early HPA-axis hyporesponsiveness (1 h after RS) and a later significant increase in avoidant Behavior on day 7 post RS. Hippocampal serotonin, noradrenaline and dopamine concentrations were unchanged 1 h post AS, but were significantly raised on day 7 post AS. Restress, however, reduced serotonin and noradrenaline levels 1 h after and on day 7 post RS, respectively, while dopamine was unchanged. In the frontal cortex only dopamine levels were altered, being significantly elevated 1 h after AS, and reduced on day 7 post RS. AS and RS thus differently effect the HPA-axis, evoking regional-specific brain monoamine changes that underlie maladaptive Behavior and other post stress-related sequelae.
Julian Eggert - One of the best experts on this subject based on the ideXlab platform.
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risk Aversive Behavior planning under multiple situations with uncertainty
International Conference on Intelligent Transportation Systems, 2015Co-Authors: Florian Damerow, Julian EggertAbstract:This paper addresses the problem of future Behavior evaluation and planning for upcoming ADAS, especially for inner city traffic scenarios. Situations in inner city traffic scenarios are generally highly complex and of high uncertainty. The Behavior in such complex scenarios differs strongly depending on the actually occurring situation. In general the current situation can only be determined with high uncertainty based on current and past sensory measurements of the ego entity and the other involved entities. Additionally a situation can change very quickly, e.g. if a traffic participant suddenly changes its Behavior. Here we propose an approach how to plan safe, but still efficient future Behavior under consideration of multiple possible situations with different occurrence probabilities. For each situation we predict prototypical future trajectories of all involved entities using a highly general, interaction aware model Foresighted Driver Model (FDM). Then, based on a continuous, probabilistic model for future risk, we build so-called predictive risk maps, one for each possible situation, and plan the own Behavior while minimizing overall risk and utility. We show that our approach generates efficient Behavior for situations with high probability, while generating a "plan b" to safely deal with improbable but risky situations.
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ITSC - Risk-Aversive Behavior Planning under Multiple Situations with Uncertainty
2015 IEEE 18th International Conference on Intelligent Transportation Systems, 2015Co-Authors: Florian Damerow, Julian EggertAbstract:This paper addresses the problem of future Behavior evaluation and planning for upcoming ADAS, especially for inner city traffic scenarios. Situations in inner city traffic scenarios are generally highly complex and of high uncertainty. The Behavior in such complex scenarios differs strongly depending on the actually occurring situation. In general the current situation can only be determined with high uncertainty based on current and past sensory measurements of the ego entity and the other involved entities. Additionally a situation can change very quickly, e.g. if a traffic participant suddenly changes its Behavior. Here we propose an approach how to plan safe, but still efficient future Behavior under consideration of multiple possible situations with different occurrence probabilities. For each situation we predict prototypical future trajectories of all involved entities using a highly general, interaction aware model Foresighted Driver Model (FDM). Then, based on a continuous, probabilistic model for future risk, we build so-called predictive risk maps, one for each possible situation, and plan the own Behavior while minimizing overall risk and utility. We show that our approach generates efficient Behavior for situations with high probability, while generating a "plan b" to safely deal with improbable but risky situations.
