The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Hyeon-kyu Lee - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of highly functionalized 5 and 6 membered aminocyclitols starting with a readily available 2 Azetidinone
Journal of Organic Chemistry, 2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involv...
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Stereoselective Synthesis of Highly Functionalized 5- and 6‑Membered Aminocyclitols Starting with a Readily Available 2‑Azetidinone
2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1–N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- and 5-membered aminocyclitols
Raghavendra Achary - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of highly functionalized 5 and 6 membered aminocyclitols starting with a readily available 2 Azetidinone
Journal of Organic Chemistry, 2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involv...
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Stereoselective Synthesis of Highly Functionalized 5- and 6‑Membered Aminocyclitols Starting with a Readily Available 2‑Azetidinone
2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1–N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- and 5-membered aminocyclitols
Hyeong Rae Kim - One of the best experts on this subject based on the ideXlab platform.
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stereoselective synthesis of highly functionalized 5 and 6 membered aminocyclitols starting with a readily available 2 Azetidinone
Journal of Organic Chemistry, 2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involv...
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Stereoselective Synthesis of Highly Functionalized 5- and 6‑Membered Aminocyclitols Starting with a Readily Available 2‑Azetidinone
2019Co-Authors: Raghavendra Achary, Hyeong Rae Kim, Hyeon-kyu LeeAbstract:Stereoselective transformations of 4-vinyl-2-Azetidinone Derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1–N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- and 5-membered aminocyclitols
Walker Graham - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 5r z 6 1 methyl 1 2 3 triazol 4 ylmethylene penem 3 carboxylic acid a potent broad spectrum β lactamase inhibitor from 6 aminopenicillanic acid
Journal of The Chemical Society-perkin Transactions 1, 1994Co-Authors: Neal Frederick Osborne, Richard J Atkins, Nigel J P Broom, Steven Coulton, John Barry Harbridge, Michael Anthony Harris, Irene Stirlingfrancois, Walker GrahamAbstract:(5R)-(Z)-6-(1-Methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid 34(BRL 42715) has been prepared from 6-aminopenicillanic acid 4(6-APA) by a short, stereoselective and efficient route via the novel intermediate, p-methoxybenzyl (5R, 6S)-6-bromopenem-3-carboxylate 17.Elaboration of 6-APA 4 to the Azetidinone disulfide 10 by established methodology, followed by reductive formylation provided the crystalline C-4 formylthio-Azetidinone Derivative 29. Cyclization of the oxalimide 28, obtained by ozonolysis of the formylthio Derivative 29, to the crystalline 6α-bromopenem ester 17 was effected by way of the phosphite-mediated carbonyl–carbonyl coupling reaction.Sequential treatment of bromopenem 17 with lithium diphenylamide, 1-methyl-1,2,3-triazole-4-carbaldehyde, and acetic anhydride gave a diastereoisomeric mixture of acylated bromohydrins 32; reductive elimination of this mixture afforded a separable mixture of (Z)- and (E)-triazolylmethylene penem esters, 33 and 35 respectively. Lewis acid-mediated deprotection of ester 33 provided (5R)(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid 34(BRL 42715) as a crystalline sodium salt monohydrate.The 6-heterocyclylmethylene penems, represented by BRL 42715, are potent inhibitors of bacterial β-lactamases and their combination with an appropriate penicillin or cephalosporin results in good synergistic activity against a broad range of β-lactamase-producing bacteria.
Omer Abdul Gader - One of the best experts on this subject based on the ideXlab platform.
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synthesis characterisation antimicrobial evaluation of Azetidinone Derivative
2014Co-Authors: Omer Abdul GaderAbstract:A new series of N-(3-chloro-2-phenyl)-4-oxoazetidin-1-yl) isonicotinamide Derivative were synthesized by the reaction of schiff base (isonicotinohydrazide and 4-hydroxybenzaldehyde) with chloroacetyl chloride respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. . The synthesized compounds did not show antibacterial activity against Staphylococcus aureus and Escherichia coli.