The Experts below are selected from a list of 510 Experts worldwide ranked by ideXlab platform
Fuhang Song - One of the best experts on this subject based on the ideXlab platform.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of industrial microbiology & biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guérin infected THP-1 cell model.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of Industrial Microbiology & Biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guerin infected THP-1 cell model.
Xinjun Zhang - One of the best experts on this subject based on the ideXlab platform.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of industrial microbiology & biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guérin infected THP-1 cell model.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of Industrial Microbiology & Biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guerin infected THP-1 cell model.
Qi Wei - One of the best experts on this subject based on the ideXlab platform.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of industrial microbiology & biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guérin infected THP-1 cell model.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of Industrial Microbiology & Biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guerin infected THP-1 cell model.
Huanqin Dai - One of the best experts on this subject based on the ideXlab platform.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of industrial microbiology & biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guérin infected THP-1 cell model.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of Industrial Microbiology & Biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guerin infected THP-1 cell model.
Lixin Zhang - One of the best experts on this subject based on the ideXlab platform.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of industrial microbiology & biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guérin infected THP-1 cell model.
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Madurastatin B3, a rare Aziridine Derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.
Journal of Industrial Microbiology & Biotechnology, 2017Co-Authors: Xinjun Zhang, Qi Wei, Huanqin Dai, Lixin Zhang, Fuhang SongAbstract:Since the discovery of the first antibiotic, natural products have played an important role in chemistry, biology and medicine. To explore the potential of bioactive compounds from microbes isolated from the southeast of Tibet, China, a crude extract library was constructed and screened against Staphylococcus aureus. The strain Nocardiopsis sp. LS150010 was scaled up and subjected to further chemical studies, resulting in the identification of N-salicyloyl-2-aminopropan-1,3-diol (2) and its rare Aziridine Derivative, madurastatin B3 (1). Their structures were determined by detailed analysis of 1D, 2D NMR and HRMS data. Compounds 1 and 2 displayed significant inhibitory activity against S. aureus and methicillin resistant S. aureus, with MIC values of 6.25 µg/mL. Compound 1 also showed potent inhibitory activity against Bacillus subtilis and Escherichia coli, as well as activity in a Mycobacterium tuberculosis Bacillus Calmette-Guerin infected THP-1 cell model.
