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Anastasia Chrysostomou - One of the best experts on this subject based on the ideXlab platform.

Fortunato Battaglia - One of the best experts on this subject based on the ideXlab platform.

  • n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-Cell Activating Factor (BAFF) transgenic mice.
    Preventive Medicine, 2012
    Co-Authors: Rosalia Crupi, Marco Cambiaghi, Richard J. Deckelbaum, Inge H Hansen, Janet Mindes, Edoardo Spina, Fortunato Battaglia
    Abstract:

    Abstract Objective Autoimmune-prone B-Cell Activating Factor transgenic mice, a mouse model of systemic lupus erythematosus and Sjogren's syndrome exhibit neuroinflammation, anxiety-like phenotype, deficit in adult hippocampal neurogenesis and impaired neurogenesis-dependent and neurogenesis-independent dentate gyrus long-term potentiation. Given that n−3 polyunsaturated fatty acids regulate hippocampal plasticity and inflammatory responses, we investigated whether n−3 polyunsaturated fatty acids-enriched diet might prevent age-dependent hippocampal changes in B-Cell Activating Factor transgenic mice. Methods B-Cell Activating Factor transgenic mice were fed for 12 weeks with either n−3 polyunsaturated fatty acids-enriched or control diet and we tested the effect of this dietary supplementation on hippocampal inflammation, progenitor cell proliferation and neurogenesis-dependent and neurogenesis-independent long-term potentiation. Results Dietary supplementation with n−-3 polyunsaturated fatty acids significantly decreased hippocampal microglial activation and increased the density of bromodeoxyuridine and doublecortin-positive newly-formed cells in the subventricular zone of hippocampus. Furthermore, B-Cell Activating Factor transgenic mice fed with n-3 polyunsaturated fatty acids-enriched diet displayed normal long-term potentiation at the medial perforant pathway/dentate gyrus connections. Conclusions The results indicate that n-3 fatty acids prevent neuroinflammation and deficits of hippocampal plasticity in B-Cell Activating Factor transgenic mice and suggest that increased n-3 fatty acids intake might represent a potential therapeutic option to prevent neuropsychiatric symptoms associated with autoimmune diseases.

  • n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-Cell Activating Factor (BAFF) transgenic mice.
    Preventive medicine, 2011
    Co-Authors: Rosalia Crupi, Marco Cambiaghi, Richard J. Deckelbaum, Janet Mindes, Edoardo Spina, Inge Hansen, Fortunato Battaglia
    Abstract:

    Autoimmune-prone B-Cell Activating Factor transgenic mice, a mouse model of systemic lupus erythematosus and Sjögren's syndrome exhibit neuroinflammation, anxiety-like phenotype, deficit in adult hippocampal neurogenesis and impaired neurogenesis-dependent and neurogenesis-independent dentate gyrus long-term potentiation. Given that n-3 polyunsaturated fatty acids regulate hippocampal plasticity and inflammatory responses, we investigated whether n-3 polyunsaturated fatty acids-enriched diet might prevent age-dependent hippocampal changes in B-Cell Activating Factor transgenic mice. B-Cell Activating Factor transgenic mice were fed for 12 weeks with either n-3 polyunsaturated fatty acids-enriched or control diet and we tested the effect of this dietary supplementation on hippocampal inflammation, progenitor cell proliferation and neurogenesis-dependent and neurogenesis-independent long-term potentiation. Dietary supplementation with n-3 polyunsaturated fatty acids significantly decreased hippocampal microglial activation and increased the density of bromodeoxyuridine and doublecortin-positive newly-formed cells in the subventricular zone of hippocampus. Furthermore, B-Cell Activating Factor transgenic mice fed with n-3 polyunsaturated fatty acids-enriched diet displayed normal long-term potentiation at the medial perforant pathway/dentate gyrus connections. The results indicate that n-3 fatty acids prevent neuroinflammation and deficits of hippocampal plasticity in B-Cell Activating Factor transgenic mice and suggest that increased n-3 fatty acids intake might represent a potential therapeutic option to prevent neuropsychiatric symptoms associated with autoimmune diseases. Copyright © 2011 Elsevier Inc. All rights reserved.

Anne Davidson - One of the best experts on this subject based on the ideXlab platform.

  • B-Cell Activating Factor targeted therapy and lupus
    Arthritis Research & Therapy, 2012
    Co-Authors: Alexis Boneparth, Anne Davidson
    Abstract:

    B-Cell Activating Factor (BAFF), a member of the family of TNF-like cytokines, supports the survival and differentiation of B cells. The successful development of belimumab, a human antibody targeting soluble BAFF, has marked an important milestone in the development of biologic therapy for treatment of systemic lupus erythematosus (SLE), although much remains unknown regarding the clinical utility of BAFF inhibition in SLE and other autoimmune diseases. In the present review, we provide an overview of the knowledge concerning BAFF's role in murine and human B-Cell development and maturation, as well as the clinical and mechanistic effects of BAFF inhibition in human SLE.

Elio Tonutti - One of the best experts on this subject based on the ideXlab platform.

  • Elevated B cell-Activating Factor of the tumour necrosis Factor family in coeliac disease
    Scandinavian journal of gastroenterology, 2007
    Co-Authors: Martina Fabris, Daniela Visentini, Alessia Picierno, R. Maieron, Renato Cannizzaro, Danilo Villalta, Francesco Curcio, Salvatore De Vita, Elio Tonutti
    Abstract:

    Objective. The B cell-Activating Factor of the tumour necrosis Factor (TNF) family (BAFF) was recently described as a critical survival Factor for B cells, and its expression is increased in several autoimmune diseases. Abnormal production of BAFF disturbs immune tolerance allowing the survival of autoreactive B cells and participates in the progression of B-Cell lymphomas. Coeliac disease (CD) is a common autoimmune disorder induced by gluten intake in genetically predisposed individuals, associated with autoantibody production and with an increased risk of lymphoma at follow-up. The purpose of this study was to investigate the possible implications of BAFF in CD. Material and methods. Seventy-three patients with small-bowel biopsies and laboratory-proven diagnosis of CD were included in the study. All serum samples were analysed before the start of a gluten-free diet (GFD). In 12 cases, one or more samples were analysed during follow-up of the GFD. Seventy-seven blood donors were taken as controls. Seru...

Fabien B. Vincent - One of the best experts on this subject based on the ideXlab platform.