The Experts below are selected from a list of 10392 Experts worldwide ranked by ideXlab platform
Leonard A. Mermel - One of the best experts on this subject based on the ideXlab platform.
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transfusion complications transfusion transmitted Babesiosis in rhode island
Transfusion, 2009Co-Authors: Shadaba Asad, Joseph D. Sweeney, Leonard A. MermelAbstract:BACKGROUND: Babesiosis is caused by an intraerythrocytic protozoan transmitted by ticks. Blood transfusion is another mode of transmission. STUDY DESIGN AND METHODS: This was a retrospective study based on Babesiosis cases reported to the Rhode Island Department of Health between 1999 and 2007. Additional cases were also identified. RESULTS: Twenty-one cases of transfusion-transmitted Babesiosis (TTB) were identified from 1999 through 2007. From 2005 through 2007, the incidence approached one case per 9000 units of blood transfused. One of 21 (5%) TTB cases was diagnosed in July, in sharp contrast to 65 of 152 (43%) of the total Babesiosis cases diagnosed during July in Rhode Island. Many cases were identified when a complete blood count with a differential was routinely requested and parasites were noted by laboratory technologists. Most patients with TTB had underlying conditions known to predispose to symptomatic infection. CONCLUSION: Blood transfusion is an important mode of Babesia transmission. The current screening method of omitting donors with a history of Babesiosis may be effective in preventing some, but not all, cases of TTB and current processing of blood products does not eradicate this parasite. Thus, a better screening test is needed. Alternatively, pathogen reduction technology could be utilized to prevent this mode of transmission.
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Transfusion-transmitted Babesiosis in Rhode Island.
Transfusion, 2009Co-Authors: Shadaba Asad, Joseph D. Sweeney, Leonard A. MermelAbstract:BACKGROUND: Babesiosis is caused by an intraerythrocytic protozoan transmitted by ticks. Blood transfusion is another mode of transmission. STUDY DESIGN AND METHODS: This was a retrospective study based on Babesiosis cases reported to the Rhode Island Department of Health between 1999 and 2007. Additional cases were also identified. RESULTS: Twenty-one cases of transfusion-transmitted Babesiosis (TTB) were identified from 1999 through 2007. From 2005 through 2007, the incidence approached one case per 9000 units of blood transfused. One of 21 (5%) TTB cases was diagnosed in July, in sharp contrast to 65 of 152 (43%) of the total Babesiosis cases diagnosed during July in Rhode Island. Many cases were identified when a complete blood count with a differential was routinely requested and parasites were noted by laboratory technologists. Most patients with TTB had underlying conditions known to predispose to symptomatic infection. CONCLUSION: Blood transfusion is an important mode of Babesia transmission. The current screening method of omitting donors with a history of Babesiosis may be effective in preventing some, but not all, cases of TTB and current processing of blood products does not eradicate this parasite. Thus, a better screening test is needed. Alternatively, pathogen reduction technology could be utilized to prevent this mode of transmission.
Shadaba Asad - One of the best experts on this subject based on the ideXlab platform.
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transfusion complications transfusion transmitted Babesiosis in rhode island
Transfusion, 2009Co-Authors: Shadaba Asad, Joseph D. Sweeney, Leonard A. MermelAbstract:BACKGROUND: Babesiosis is caused by an intraerythrocytic protozoan transmitted by ticks. Blood transfusion is another mode of transmission. STUDY DESIGN AND METHODS: This was a retrospective study based on Babesiosis cases reported to the Rhode Island Department of Health between 1999 and 2007. Additional cases were also identified. RESULTS: Twenty-one cases of transfusion-transmitted Babesiosis (TTB) were identified from 1999 through 2007. From 2005 through 2007, the incidence approached one case per 9000 units of blood transfused. One of 21 (5%) TTB cases was diagnosed in July, in sharp contrast to 65 of 152 (43%) of the total Babesiosis cases diagnosed during July in Rhode Island. Many cases were identified when a complete blood count with a differential was routinely requested and parasites were noted by laboratory technologists. Most patients with TTB had underlying conditions known to predispose to symptomatic infection. CONCLUSION: Blood transfusion is an important mode of Babesia transmission. The current screening method of omitting donors with a history of Babesiosis may be effective in preventing some, but not all, cases of TTB and current processing of blood products does not eradicate this parasite. Thus, a better screening test is needed. Alternatively, pathogen reduction technology could be utilized to prevent this mode of transmission.
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Transfusion-transmitted Babesiosis in Rhode Island.
Transfusion, 2009Co-Authors: Shadaba Asad, Joseph D. Sweeney, Leonard A. MermelAbstract:BACKGROUND: Babesiosis is caused by an intraerythrocytic protozoan transmitted by ticks. Blood transfusion is another mode of transmission. STUDY DESIGN AND METHODS: This was a retrospective study based on Babesiosis cases reported to the Rhode Island Department of Health between 1999 and 2007. Additional cases were also identified. RESULTS: Twenty-one cases of transfusion-transmitted Babesiosis (TTB) were identified from 1999 through 2007. From 2005 through 2007, the incidence approached one case per 9000 units of blood transfused. One of 21 (5%) TTB cases was diagnosed in July, in sharp contrast to 65 of 152 (43%) of the total Babesiosis cases diagnosed during July in Rhode Island. Many cases were identified when a complete blood count with a differential was routinely requested and parasites were noted by laboratory technologists. Most patients with TTB had underlying conditions known to predispose to symptomatic infection. CONCLUSION: Blood transfusion is an important mode of Babesia transmission. The current screening method of omitting donors with a history of Babesiosis may be effective in preventing some, but not all, cases of TTB and current processing of blood products does not eradicate this parasite. Thus, a better screening test is needed. Alternatively, pathogen reduction technology could be utilized to prevent this mode of transmission.
Alan M. Fein - One of the best experts on this subject based on the ideXlab platform.
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Delayed Onset Adult Respiratory Distress Syndrome in Babesiosis
Chest, 1994Co-Authors: Mitchell L. Horowitz, Frank Coletta, Alan M. FeinAbstract:Reported herein is a second case of a patient who developed adult respiratory distress syndrome secondary to Babesiosis. The features of acute lung injury after Babesiosis will be described.
Jeanne V. Linden - One of the best experts on this subject based on the ideXlab platform.
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transfusion transmitted and community acquired Babesiosis in new york 2004 to 2015
Transfusion, 2018Co-Authors: Jeanne V. Linden, Melissa A Prusinski, Lauren A Crowder, Laura Tonnetti, Susan L Stramer, Debra Kessler, Jennifer L White, Beth H Shaz, Danuta OlkowskaAbstract:BACKGROUND Babesiosis is a potentially life-threatening zoonotic infection most frequently caused by the intraerythrocytic parasite Babesia microti. The pathogen is usually tickborne, but may also be transfusion or vertically transmitted. Healthy persons, including blood donors, may be asymptomatic and unaware they are infected. Immunocompromised patients are at increased risk for symptomatic disease. STUDY DESIGN AND METHODS All reported community-acquired Babesiosis cases in New York from 2004 to 2015 were evaluated, enumerated, and characterized. All potential transfusion-transmitted Babesiosis (TTB) cases reported through one or more of three public health surveillance systems were investigated to determine the likelihood of transfusion transmission. In addition, host-seeking ticks were actively collected in public parks and other likely sites of human exposure to B. microti. RESULTS From 2004 to 2015, a total of 3799 cases of Babesiosis were found; 55 (1.4%) of these were linked to transfusion. The incidence of both community-acquired Babesiosis and TTB increased significantly during the 12-year study period. The geographic range of both ticks and tickborne infections also expanded. Among TTB cases, 95% of recipients had at least one risk factor for symptomatic disease. Implicated donors resided in five states, including in 10 New York counties. More than half of implicated donors resided in counties known to be B. microti endemic. CONCLUSION The increasing incidence of TTB correlated with increases in community-acquired Babesiosis and infection of ticks with B. microti. Surveillance of ticks and community-acquired cases may aid identification of emerging areas at risk for Babesia transfusion transmission.
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Transfusion-associated transmission of Babesiosis in New York State.
Transfusion, 2000Co-Authors: Jeanne V. Linden, S.j. Wong, F.k. Chu, G.b. Schmidt, C. BiancoAbstract:BACKGROUND: Babesiosis can be life-threatening in immunocompromised individuals. Although the disease is usually transmitted by tick bite, more than 20 cases have been reported of infection transmitted by transfusion of blood or blood components obtained from apparently healthy donors from endemic areas in the United States. This report describes several recent cases of transfusion-transmitted Babesiosis in New York State. STUDY DESIGN AND METHODS: Transfusion-associated incidents of Babesiosis infection were identified and investigated. Seroprevalence of Babesiosis in healthy blood donors in a highly endemic area was ascertained. RESULTS: In three incidents, Babesiosis was diagnosed in five of eight patients given infected blood: two premature infants, an elderly patient with gastrointestinal bleeding, and two patients with thalassemia. Seroprevalence in blood donors on Shelter Island (Suffolk County, eastern Long Island), a highly endemic area, was 4.3 percent in May 1998. CONCLUSIONS: Infected donors lived in endemic areas and were asymptomatic with no history of tick bite. Blood collected in January 1997 from one donor was infectious. Those transfusion recipients who were infected were neonatal, elderly, or chronically transfused patients. Babesiosis should be included in the differential diagnosis of febrile illness in immunocompromised recipients of blood transfusion, particularly in the Northeastern United States.
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a cluster of transfusion associated Babesiosis cases traced to a single asymptomatic donor
JAMA, 1999Co-Authors: Joanna Dobroszycki, Barbara L. Herwaldt, Jeanne V. Linden, Fouad N Boctor, James R Miller, Mark L Eberhard, Jing Ja Yoon, Nahed M Ali, Herbert B Tanowitz, Fitzroy GrahamAbstract:ContextThe risk of acquiring Babesiosis by blood transfusion is largely unknown since in areas where it is endemic it is often an asymptomatic infection.ObjectiveTo investigate and treat a cluster of blood transfusion–associated Babesiosis cases.DesignCase series and epidemiologic investigation.SettingUrban inner-city hospital.PatientsSix persons who received Babesia microti–infected blood components from a donor.Main Outcome MeasureDiagnosis and successful therapy of Babesiosis following transfusion.ResultsSix individuals (1 adult, 1 child, and 4 neonates) were exposed to products from a single blood donation by an asymptomatic Babesia-infected donor. Three of the 6 exposed patients became parasitemic. Polymerase chain reaction testing, animal inoculation studies, and indirect immunofluorescent antibody testing were used to confirm the presence of Babesia microti in the donor's blood and to establish the presence of infection in 3 of the 6 recipients. The 3 infected recipients and 1 additional recipient were treated without incident.ConclusionPhysicians should consider Babesiosis in the differential diagnosis of a febrile hemolytic disorder after blood transfusion. Prompt diagnosis is important since Babesiosis is responsive to antibiotic therapy and, untreated, can be a fatal disease in certain risk groups.
Julie Katz Karp - One of the best experts on this subject based on the ideXlab platform.
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Transfusion-Transmitted Babesiosis.
Archives of pathology & laboratory medicine, 2018Co-Authors: Tatiana Villatoro, Julie Katz KarpAbstract:Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood transfusion. In the United States, the first case of transfusion-transmitted Babesiosis was recognized in 1979, and in recent years, the incidence has rapidly increased. Because most of the infected blood donors do not experience any symptoms, they pose a significant risk to the blood supply. Donor deferral for a history of Babesiosis is currently performed but is ineffective. In March 2018, the FDA licensed a DNA PCR and antibody assay that were used in tandem in pivotal trials for screening blood donors for B microti; with other assays still being evaluated under investigational new drug protocols. Blood donation screening is essential to reducing the risk of transfusion-transmitted Babesiosis, which is why blood centers collecting in geographic regions of highest risk have been testing since approximately 2010. Investigational NAT assays of higher sensitivity are pending FDA review. Further, in July 2018, the FDA issued a draft guidance for reducing the risk of transfusion-transmitted Babesiosis. Release of the final guidance may be postponed until sensitivities and specificities of all current and potential strategies have been properly evaluated.
