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Artur Schmidtchen - One of the best experts on this subject based on the ideXlab platform.

  • Identification of Bacterial Biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Scientific Reports, 2017
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Artur Schmidtchen
    Abstract:

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to Bacterial colonization and infection. In the present study, Bacterial Biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus ( S . aureus ) isolates from lesional skin of patients with AD, produced a substantial amount of Biofilm in vitro . S . aureus Biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared with results obtained using planktonic cells. Confocal microscopy analysis showed that LL-37 binds to the S . aureus Biofilms. Immuno-gold staining of S . aureus Biofilm of AD skin detected the S . aureus derived protease staphopain adjacent to the bacteria. In vitro , staphopain B degraded LL-37 into shorter peptide fragments. Further, LL-37 significantly inhibited S . aureus Biofilm formation, but no such effects were observed for the degradation products. The data presented here provide novel information on staphopains present in S . aureus Biofilms in vivo , and illustrate the complex interplay between Biofilm and LL-37 in skin of AD patients, possibly leading to a disturbed host defense, which facilitates Bacterial persistence.

  • Bacterial Biofilm and the s aureus derived protease staphopain are present on the skin surface of patients with atopic dermatitis
    Experimental Dermatology, 2016
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Matthias Mörgelin, Sven Kjellström, Julia R Davies, Artur Schmidtchen
    Abstract:

    Bacterial Biofilm and the S. aureus derived protease, staphopain, are present on the skin surface of patients with atopic dermatitis

Andreas Sonesson - One of the best experts on this subject based on the ideXlab platform.

  • Identification of Bacterial Biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Scientific Reports, 2017
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Artur Schmidtchen
    Abstract:

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to Bacterial colonization and infection. In the present study, Bacterial Biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus ( S . aureus ) isolates from lesional skin of patients with AD, produced a substantial amount of Biofilm in vitro . S . aureus Biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared with results obtained using planktonic cells. Confocal microscopy analysis showed that LL-37 binds to the S . aureus Biofilms. Immuno-gold staining of S . aureus Biofilm of AD skin detected the S . aureus derived protease staphopain adjacent to the bacteria. In vitro , staphopain B degraded LL-37 into shorter peptide fragments. Further, LL-37 significantly inhibited S . aureus Biofilm formation, but no such effects were observed for the degradation products. The data presented here provide novel information on staphopains present in S . aureus Biofilms in vivo , and illustrate the complex interplay between Biofilm and LL-37 in skin of AD patients, possibly leading to a disturbed host defense, which facilitates Bacterial persistence.

  • Bacterial Biofilm and the s aureus derived protease staphopain are present on the skin surface of patients with atopic dermatitis
    Experimental Dermatology, 2016
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Matthias Mörgelin, Sven Kjellström, Julia R Davies, Artur Schmidtchen
    Abstract:

    Bacterial Biofilm and the S. aureus derived protease, staphopain, are present on the skin surface of patients with atopic dermatitis

Jan Potempa - One of the best experts on this subject based on the ideXlab platform.

  • Identification of Bacterial Biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Scientific Reports, 2017
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Artur Schmidtchen
    Abstract:

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to Bacterial colonization and infection. In the present study, Bacterial Biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus ( S . aureus ) isolates from lesional skin of patients with AD, produced a substantial amount of Biofilm in vitro . S . aureus Biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared with results obtained using planktonic cells. Confocal microscopy analysis showed that LL-37 binds to the S . aureus Biofilms. Immuno-gold staining of S . aureus Biofilm of AD skin detected the S . aureus derived protease staphopain adjacent to the bacteria. In vitro , staphopain B degraded LL-37 into shorter peptide fragments. Further, LL-37 significantly inhibited S . aureus Biofilm formation, but no such effects were observed for the degradation products. The data presented here provide novel information on staphopains present in S . aureus Biofilms in vivo , and illustrate the complex interplay between Biofilm and LL-37 in skin of AD patients, possibly leading to a disturbed host defense, which facilitates Bacterial persistence.

  • Bacterial Biofilm and the s aureus derived protease staphopain are present on the skin surface of patients with atopic dermatitis
    Experimental Dermatology, 2016
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Matthias Mörgelin, Sven Kjellström, Julia R Davies, Artur Schmidtchen
    Abstract:

    Bacterial Biofilm and the S. aureus derived protease, staphopain, are present on the skin surface of patients with atopic dermatitis

Sven Kjellström - One of the best experts on this subject based on the ideXlab platform.

  • Identification of Bacterial Biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Scientific Reports, 2017
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Artur Schmidtchen
    Abstract:

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to Bacterial colonization and infection. In the present study, Bacterial Biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus ( S . aureus ) isolates from lesional skin of patients with AD, produced a substantial amount of Biofilm in vitro . S . aureus Biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared with results obtained using planktonic cells. Confocal microscopy analysis showed that LL-37 binds to the S . aureus Biofilms. Immuno-gold staining of S . aureus Biofilm of AD skin detected the S . aureus derived protease staphopain adjacent to the bacteria. In vitro , staphopain B degraded LL-37 into shorter peptide fragments. Further, LL-37 significantly inhibited S . aureus Biofilm formation, but no such effects were observed for the degradation products. The data presented here provide novel information on staphopains present in S . aureus Biofilms in vivo , and illustrate the complex interplay between Biofilm and LL-37 in skin of AD patients, possibly leading to a disturbed host defense, which facilitates Bacterial persistence.

  • Bacterial Biofilm and the s aureus derived protease staphopain are present on the skin surface of patients with atopic dermatitis
    Experimental Dermatology, 2016
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Matthias Mörgelin, Sven Kjellström, Julia R Davies, Artur Schmidtchen
    Abstract:

    Bacterial Biofilm and the S. aureus derived protease, staphopain, are present on the skin surface of patients with atopic dermatitis

Matthias Mörgelin - One of the best experts on this subject based on the ideXlab platform.

  • Identification of Bacterial Biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis
    Scientific Reports, 2017
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Sigrid Eriksson, Matthias Mörgelin, Sven Kjellström, Julia Davies, Artur Schmidtchen
    Abstract:

    Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by an impaired epidermal barrier, dysregulation of innate and adaptive immunity, and a high susceptibility to Bacterial colonization and infection. In the present study, Bacterial Biofilm was visualized by electron microscopy at the surface of AD skin. Correspondingly, Staphylococcus aureus ( S . aureus ) isolates from lesional skin of patients with AD, produced a substantial amount of Biofilm in vitro . S . aureus Biofilms showed less susceptibility to killing by the antimicrobial peptide LL-37 when compared with results obtained using planktonic cells. Confocal microscopy analysis showed that LL-37 binds to the S . aureus Biofilms. Immuno-gold staining of S . aureus Biofilm of AD skin detected the S . aureus derived protease staphopain adjacent to the bacteria. In vitro , staphopain B degraded LL-37 into shorter peptide fragments. Further, LL-37 significantly inhibited S . aureus Biofilm formation, but no such effects were observed for the degradation products. The data presented here provide novel information on staphopains present in S . aureus Biofilms in vivo , and illustrate the complex interplay between Biofilm and LL-37 in skin of AD patients, possibly leading to a disturbed host defense, which facilitates Bacterial persistence.

  • Bacterial Biofilm and the s aureus derived protease staphopain are present on the skin surface of patients with atopic dermatitis
    Experimental Dermatology, 2016
    Co-Authors: Andreas Sonesson, Jan Potempa, Kornelia Przybyszewska, Matthias Mörgelin, Sven Kjellström, Julia R Davies, Artur Schmidtchen
    Abstract:

    Bacterial Biofilm and the S. aureus derived protease, staphopain, are present on the skin surface of patients with atopic dermatitis