The Experts below are selected from a list of 148854 Experts worldwide ranked by ideXlab platform
Makeda Semret - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic Bacteriology in District Hospitals in Sub-Saharan Africa: At the Forefront of the Containment of Antimicrobial Resistance.
Frontiers in Medicine, 2019Co-Authors: Jan Jacobs, Cedric P Yansouni, Octavie Lunguya, Makeda Semret, Dissou Affolabi, Liselotte Hardy, Olivier VandenbergAbstract:This review provides an update on the factors fuelling antimicrobial resistance and shows the impact of these factors in low-resource settings. We detail the challenges and barriers to integrating clinical Bacteriology in hospitals in low-resource settings, as well as the opportunities provided by the recent capacity building efforts of national laboratory networks focused on vertical single-disease programmes. The programmes for HIV, tuberculosis and malaria have considerably improved laboratory medicine in sub-Saharan Africa, paving the way for clinical Bacteriology. Furthermore, special attention is paid to topics that are less familiar to the general medical community, such as the crucial role of regulatory frameworks for diagnostics and the educational profile required for a productive laboratory workforce in low-resource settings. Traditionally, clinical Bacteriology laboratories have been a part of higher levels of care, and, as a result, they were poorly linked to clinical practices and thus underused. By establishing and consolidating clinical Bacteriology laboratories at the hospital referral level in low-resource settings, routine patient care data can be collected for surveillance, antibiotic stewardship and infection prevention and control. Together, these activities form a synergistic tripartite effort at the frontline of the emergence and spread of multi-drug resistant bacteria. If challenges related to staff, funding, scale and the specific nature of clinical Bacteriology are prioritized, a major leap forward in the containment of antimicrobial resistance can be achieved. The mobilization of resources coordinated by national laboratory plans and interventions tailored by a good understanding of the hospital microcosm will be crucial to success, and further contributions will be made by market interventions and business models for diagnostic laboratories. The future clinical Bacteriology laboratory in a low-resource setting will not be an “entry-level version” of its counterparts in high-resource settings, but a purpose-built, well-conceived, cost-effective and efficient diagnostic facility at the forefront of antimicrobial resistance containment.
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clinical Bacteriology in low resource settings today s solutions
Lancet Infectious Diseases, 2018Co-Authors: Cedric P Yansouni, Jeanbaptiste Ronat, Delphine Martiny, Makeda Semret, Sien Ombelet, Erika Vlieghe, Timothy R WalshAbstract:Summary Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical Bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical Bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical Bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access t raining materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical Bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections.
Jan Jacobs - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic Bacteriology in District Hospitals in Sub-Saharan Africa: At the Forefront of the Containment of Antimicrobial Resistance.
Frontiers in Medicine, 2019Co-Authors: Jan Jacobs, Cedric P Yansouni, Octavie Lunguya, Makeda Semret, Dissou Affolabi, Liselotte Hardy, Olivier VandenbergAbstract:This review provides an update on the factors fuelling antimicrobial resistance and shows the impact of these factors in low-resource settings. We detail the challenges and barriers to integrating clinical Bacteriology in hospitals in low-resource settings, as well as the opportunities provided by the recent capacity building efforts of national laboratory networks focused on vertical single-disease programmes. The programmes for HIV, tuberculosis and malaria have considerably improved laboratory medicine in sub-Saharan Africa, paving the way for clinical Bacteriology. Furthermore, special attention is paid to topics that are less familiar to the general medical community, such as the crucial role of regulatory frameworks for diagnostics and the educational profile required for a productive laboratory workforce in low-resource settings. Traditionally, clinical Bacteriology laboratories have been a part of higher levels of care, and, as a result, they were poorly linked to clinical practices and thus underused. By establishing and consolidating clinical Bacteriology laboratories at the hospital referral level in low-resource settings, routine patient care data can be collected for surveillance, antibiotic stewardship and infection prevention and control. Together, these activities form a synergistic tripartite effort at the frontline of the emergence and spread of multi-drug resistant bacteria. If challenges related to staff, funding, scale and the specific nature of clinical Bacteriology are prioritized, a major leap forward in the containment of antimicrobial resistance can be achieved. The mobilization of resources coordinated by national laboratory plans and interventions tailored by a good understanding of the hospital microcosm will be crucial to success, and further contributions will be made by market interventions and business models for diagnostic laboratories. The future clinical Bacteriology laboratory in a low-resource setting will not be an “entry-level version” of its counterparts in high-resource settings, but a purpose-built, well-conceived, cost-effective and efficient diagnostic facility at the forefront of antimicrobial resistance containment.
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implementation of quality management for clinical Bacteriology in low resource settings
Clinical Microbiology and Infection, 2017Co-Authors: Barbara Barbe, Cedric P Yansouni, Dissou Affolabi, Jan JacobsAbstract:Abstract Background The declining trend of malaria and the recent prioritization of containment of antimicrobial resistance have created a momentum to implement clinical Bacteriology in low-resource settings. Successful implementation relies on guidance by a quality management system (QMS). Over the past decade international initiatives were launched towards implementation of QMS in HIV/AIDS, tuberculosis and malaria. Aims To describe the progress towards accreditation of medical laboratories and to identify the challenges and best practices for implementation of QMS in clinical Bacteriology in low-resource settings. Sources Published literature, online reports and websites related to the implementation of laboratory QMS, accreditation of medical laboratories and initiatives for containment of antimicrobial resistance. Content Apart from the limitations of infrastructure, equipment, consumables and staff, QMS are challenged with the complexity of clinical Bacteriology and the healthcare context in low-resource settings (small-scale laboratories, attitudes and perception of staff, absence of laboratory information systems). Likewise, most international initiatives addressing laboratory health strengthening have focused on public health and outbreak management rather than on hospital based patient care. Best practices to implement quality-assured clinical Bacteriology in low-resource settings include alignment with national regulations and public health reference laboratories, participating in external quality assurance programmes, support from the hospital's management, starting with attainable projects, conducting error review and daily bench-side supervision, looking for locally adapted solutions, stimulating ownership and extending existing training programmes to clinical Bacteriology. Implications The implementation of QMS in clinical Bacteriology in hospital settings will ultimately boost a culture of quality to all sectors of healthcare in low-resource settings.
Sien Ombelet - One of the best experts on this subject based on the ideXlab platform.
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clinical Bacteriology in low resource settings today s solutions
Lancet Infectious Diseases, 2018Co-Authors: Cedric P Yansouni, Jeanbaptiste Ronat, Delphine Martiny, Makeda Semret, Sien Ombelet, Erika Vlieghe, Timothy R WalshAbstract:Summary Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical Bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical Bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical Bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access t raining materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical Bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections.
Cedric P Yansouni - One of the best experts on this subject based on the ideXlab platform.
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Diagnostic Bacteriology in District Hospitals in Sub-Saharan Africa: At the Forefront of the Containment of Antimicrobial Resistance.
Frontiers in Medicine, 2019Co-Authors: Jan Jacobs, Cedric P Yansouni, Octavie Lunguya, Makeda Semret, Dissou Affolabi, Liselotte Hardy, Olivier VandenbergAbstract:This review provides an update on the factors fuelling antimicrobial resistance and shows the impact of these factors in low-resource settings. We detail the challenges and barriers to integrating clinical Bacteriology in hospitals in low-resource settings, as well as the opportunities provided by the recent capacity building efforts of national laboratory networks focused on vertical single-disease programmes. The programmes for HIV, tuberculosis and malaria have considerably improved laboratory medicine in sub-Saharan Africa, paving the way for clinical Bacteriology. Furthermore, special attention is paid to topics that are less familiar to the general medical community, such as the crucial role of regulatory frameworks for diagnostics and the educational profile required for a productive laboratory workforce in low-resource settings. Traditionally, clinical Bacteriology laboratories have been a part of higher levels of care, and, as a result, they were poorly linked to clinical practices and thus underused. By establishing and consolidating clinical Bacteriology laboratories at the hospital referral level in low-resource settings, routine patient care data can be collected for surveillance, antibiotic stewardship and infection prevention and control. Together, these activities form a synergistic tripartite effort at the frontline of the emergence and spread of multi-drug resistant bacteria. If challenges related to staff, funding, scale and the specific nature of clinical Bacteriology are prioritized, a major leap forward in the containment of antimicrobial resistance can be achieved. The mobilization of resources coordinated by national laboratory plans and interventions tailored by a good understanding of the hospital microcosm will be crucial to success, and further contributions will be made by market interventions and business models for diagnostic laboratories. The future clinical Bacteriology laboratory in a low-resource setting will not be an “entry-level version” of its counterparts in high-resource settings, but a purpose-built, well-conceived, cost-effective and efficient diagnostic facility at the forefront of antimicrobial resistance containment.
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clinical Bacteriology in low resource settings today s solutions
Lancet Infectious Diseases, 2018Co-Authors: Cedric P Yansouni, Jeanbaptiste Ronat, Delphine Martiny, Makeda Semret, Sien Ombelet, Erika Vlieghe, Timothy R WalshAbstract:Summary Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical Bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical Bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical Bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access t raining materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical Bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections.
-
implementation of quality management for clinical Bacteriology in low resource settings
Clinical Microbiology and Infection, 2017Co-Authors: Barbara Barbe, Cedric P Yansouni, Dissou Affolabi, Jan JacobsAbstract:Abstract Background The declining trend of malaria and the recent prioritization of containment of antimicrobial resistance have created a momentum to implement clinical Bacteriology in low-resource settings. Successful implementation relies on guidance by a quality management system (QMS). Over the past decade international initiatives were launched towards implementation of QMS in HIV/AIDS, tuberculosis and malaria. Aims To describe the progress towards accreditation of medical laboratories and to identify the challenges and best practices for implementation of QMS in clinical Bacteriology in low-resource settings. Sources Published literature, online reports and websites related to the implementation of laboratory QMS, accreditation of medical laboratories and initiatives for containment of antimicrobial resistance. Content Apart from the limitations of infrastructure, equipment, consumables and staff, QMS are challenged with the complexity of clinical Bacteriology and the healthcare context in low-resource settings (small-scale laboratories, attitudes and perception of staff, absence of laboratory information systems). Likewise, most international initiatives addressing laboratory health strengthening have focused on public health and outbreak management rather than on hospital based patient care. Best practices to implement quality-assured clinical Bacteriology in low-resource settings include alignment with national regulations and public health reference laboratories, participating in external quality assurance programmes, support from the hospital's management, starting with attainable projects, conducting error review and daily bench-side supervision, looking for locally adapted solutions, stimulating ownership and extending existing training programmes to clinical Bacteriology. Implications The implementation of QMS in clinical Bacteriology in hospital settings will ultimately boost a culture of quality to all sectors of healthcare in low-resource settings.
Erika Vlieghe - One of the best experts on this subject based on the ideXlab platform.
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clinical Bacteriology in low resource settings today s solutions
Lancet Infectious Diseases, 2018Co-Authors: Cedric P Yansouni, Jeanbaptiste Ronat, Delphine Martiny, Makeda Semret, Sien Ombelet, Erika Vlieghe, Timothy R WalshAbstract:Summary Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical Bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical Bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical Bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access t raining materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical Bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections.
