The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
S Gollapudi - One of the best experts on this subject based on the ideXlab platform.
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efficacy of trovafloxacin for treatment of experimental Bacteroides Infection in young and senescent mice
Antimicrobial Agents and Chemotherapy, 1997Co-Authors: Haragopal Thadepalli, See Kean Chuah, U Reddy, N Hanna, R Clark, R J Polzer, S GollapudiAbstract:We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
Haragopal Thadepalli - One of the best experts on this subject based on the ideXlab platform.
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efficacy of trovafloxacin for treatment of experimental Bacteroides Infection in young and senescent mice
Antimicrobial Agents and Chemotherapy, 1997Co-Authors: Haragopal Thadepalli, See Kean Chuah, U Reddy, N Hanna, R Clark, R J Polzer, S GollapudiAbstract:We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
See Kean Chuah - One of the best experts on this subject based on the ideXlab platform.
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efficacy of trovafloxacin for treatment of experimental Bacteroides Infection in young and senescent mice
Antimicrobial Agents and Chemotherapy, 1997Co-Authors: Haragopal Thadepalli, See Kean Chuah, U Reddy, N Hanna, R Clark, R J Polzer, S GollapudiAbstract:We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
U Reddy - One of the best experts on this subject based on the ideXlab platform.
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efficacy of trovafloxacin for treatment of experimental Bacteroides Infection in young and senescent mice
Antimicrobial Agents and Chemotherapy, 1997Co-Authors: Haragopal Thadepalli, See Kean Chuah, U Reddy, N Hanna, R Clark, R J Polzer, S GollapudiAbstract:We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
N Hanna - One of the best experts on this subject based on the ideXlab platform.
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efficacy of trovafloxacin for treatment of experimental Bacteroides Infection in young and senescent mice
Antimicrobial Agents and Chemotherapy, 1997Co-Authors: Haragopal Thadepalli, See Kean Chuah, U Reddy, N Hanna, R Clark, R J Polzer, S GollapudiAbstract:We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. The development of abscess formation, the number of viable organisms, and antibiotic concentrations were measured, and the values for young and old mice were compared. Trovafloxacin was well distributed to the tissues in both young and old animals. Although the pharmacokinetics and concentrations of trovafloxacin in serum were similar between young and old mice, the levels in tissue were higher in senescent mice than in young mice. Trovafloxacin therapy sterilized abscesses in 94% of young mice and in 73% of old mice, but this difference was not significant. This therapeutic response to trovafloxacin was similar to that seen with clindamycin. These results suggest that aging may not have any adverse effect on the therapeutic outcome for intra-abdominal abscesses caused by B. fragilis.
