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Bagg Albino Mouse

The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform

Franz Halberg – 1st expert on this subject based on the ideXlab platform

  • Chronobiologic response modifiers and breast cancer development: classical background and chronobiologic tasks remaining.
    in Vivo, 1992
    Co-Authors: G. Cornélissen, Franz Halberg

    Abstract:

    : Mapping the chronome’s multi-frequency (about-daily, -weekly, and -yearly) neuroendocrine and immune rhythms can help determine when potential chronobiologic response modifiers (CBRMs) should be applied. Aimed at shielding in time by manipulating rhythms, CBRMs may be pertinent to all stages of carcinogenesis, from prevention to treatment, by forestalling the neuroendocrine, immunologic or cell cycle-related recurrent susceptibility peaks from getting aligned, favoring cancerous growth. Pituitary/hypothalamic isografts in the virus-free Bagg Albino Mouse and designs described as heterophasic allow the systematic investigation of the effect of internal shifts among neuroendocrines. Rhythm manipulation by CBRMs can then aim at lowering (breast or prostate) cancer risk by reproducing identified favorable low risk chronome configurations such as a circannual amplitude in blood that is small for TSH and large for prolactin in women and vice versa for men.

G. Cornélissen – 2nd expert on this subject based on the ideXlab platform

  • Chronobiologic response modifiers and breast cancer development: classical background and chronobiologic tasks remaining.
    in Vivo, 1992
    Co-Authors: G. Cornélissen, Franz Halberg

    Abstract:

    : Mapping the chronome’s multi-frequency (about-daily, -weekly, and -yearly) neuroendocrine and immune rhythms can help determine when potential chronobiologic response modifiers (CBRMs) should be applied. Aimed at shielding in time by manipulating rhythms, CBRMs may be pertinent to all stages of carcinogenesis, from prevention to treatment, by forestalling the neuroendocrine, immunologic or cell cycle-related recurrent susceptibility peaks from getting aligned, favoring cancerous growth. Pituitary/hypothalamic isografts in the virus-free Bagg Albino Mouse and designs described as heterophasic allow the systematic investigation of the effect of internal shifts among neuroendocrines. Rhythm manipulation by CBRMs can then aim at lowering (breast or prostate) cancer risk by reproducing identified favorable low risk chronome configurations such as a circannual amplitude in blood that is small for TSH and large for prolactin in women and vice versa for men.