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Y. Hashimoto - One of the best experts on this subject based on the ideXlab platform.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen beta-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by beta-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their duration of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of beta-carbolines in the brain. The smaller ED50 values of beta-carbolines that cause tremors/convulsions showed lower levels of beta-carbolines in brain tissue.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen β-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by β-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their durations of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of β-carbolines in the brain. The smaller ED50 values of β-carbolines that cause tremors/convulsions showed lower levels of β-carbolines in brain tissue.
Kazuko Kawanishi - One of the best experts on this subject based on the ideXlab platform.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen beta-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by beta-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their duration of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of beta-carbolines in the brain. The smaller ED50 values of beta-carbolines that cause tremors/convulsions showed lower levels of beta-carbolines in brain tissue.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen β-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by β-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their durations of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of β-carbolines in the brain. The smaller ED50 values of β-carbolines that cause tremors/convulsions showed lower levels of β-carbolines in brain tissue.
Manuel-josé Barbanoj - One of the best experts on this subject based on the ideXlab platform.
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Autonomic, neuroendocrine, and immunological effects of ayahuasca: a comparative study with d-amphetamine.
Journal of Clinical Psychopharmacology, 2011Co-Authors: Rafael G. Dos Santos, Manuel-josé Barbanoj, Marta Valle, José Carlos Bouso, Josep F. Nomdedeu, José Rodríguez-espinosa, Ethan H. Mcilhenny, Steven A. Barker, Jordi RibaAbstract:AbstractAyahuasca is an Amazonian psychotropic plant tea combining the 5-HT2A agonist N,N-dimethyltryptamine (DMT) and monoamine oxidase-inhibiting β-carboline alkaloids that render DMT orally active. The tea, obtained from Banisteriopsis caapi and Psychotria viridis, has traditionally been used for
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Effects of the South American Psychoactive Beverage Ayahuasca on Regional Brain Electrical Activity in Humans: A Functional Neuroimaging Study Using Low-Resolution Electromagnetic Tomography
Neuropsychobiology, 2004Co-Authors: Jordi Riba, Bernd Saletu, Peter Anderer, Francesc Jané, Manuel-josé BarbanojAbstract:Ayahuasca, a South American psychotropic plant tea obtained from Banisteriopsis caapi and Psychotria viridis , combines monoamine oxidase-inhibi
Pal Biswajit - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Antiparkinson’s activity of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi-plants with Monoamine Oxidase-B (MAO-B) inhibition potential.
2015Co-Authors: Pal BiswajitAbstract:INTRODUCTION : Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of mesencephalic dopaminergic neurons in the substantia nigra innervating the striatum. It was first described by neurologist James Parkinson in 1817 that he called ‘‘Shaking Palsy’’, or ‘‘paralysis agitans’’. The causes are unknown although risk factors in the genetic and toxic domain are being discovered. An important pathophysiological feature in PD is the loss of part of the dopaminergic neurons in the substantia nigra (SN) resulting in a specific dysorganisation of the complicated basal ganglia (BG) circuits. The relay functions at the level of the striatum e.g., are out of balance leading to disturbed subcorticocortical interactions. Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily affecting people of ages over 55 years (approximately 1.5% to 2.0%), although young adults and even children can also be affected. Research on the pathogenesis of PD has rapidly advanced due to the development of animal models. Through the use of these models, the striatal dopamine deficiency could be associated with the motor symptoms of PD, and levodopa (dihydroxyphenylalanine or L-dopa) was first applied to compensate striatal dopamine losses. L-Dopa treatment still remains the standard of PD therapies. Unfortunately, long-time use of L-dopa results in dyskinesia (involuntary movements). Moreover, the specific etiology of PD is still unknown. Thus, the development of animal models is essential for better understanding pathogenesis and progression of PD and testing therapeutic agents for the treatment of PD patients. AIM OF THE RESEARCH : • To investigate whether monoamine oxidase-B (MAO-B) inhibition potential plants [Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi] protects brain against neurodegenaration in 6-OHDA rat models, and to analyse the murine preclinical therapeutic efficacy of test drugs in attaining postural stability after completion of treatment. • To explore the beneficial effects of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in reducing neurodegenaration by controlling iron induced neurotoxicity, retaining dopamine concentrations and lowered oxidative stress in experimental PD. • To study the effectiveness of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi for neuroprotection in PD model through controlling MAO-B associated pathways of metabolism. OBJECTIVE : In the present study, we would like to evaluate the possible Anti-Parkinson’s activity of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi plants which are showing monoamine oxidase-B (MAO-B) inhibition and anti-oxidant activity and to find out the possible actions of these plants for alleviating or preventing the neurodegeneration and mitochondrial dysfunction for the treatment of Parkinson’s disease. Monoamine oxidase (MAO), a flavin-containing enzyme, is widely distributed in both the central and peripheral nervous systems20 and plays a central role in the control of substrate availability and activity. MAO catalyzes the oxidation of a variety of amine-containing neurotransmitters to yield the corresponding aldehyde, hydrogen peroxide (H2O2), and ammonia17. MAO exists in two forms, MAO-A and MAO-B, which are distinguished on the basis of different pharmacological and biochemical characteristics. MAO is a key enzyme in catecholamine metabolism, and increased catecholamine metabolism seen in aging has been extensively studied. The control on MAO activity may alleviate symptoms and slow the progression of neurodegenerative disorders. In humans, MAO-B activity increases with age18 and is especially elevated in certain neurodegenerative diseases19. Therefore, inhibition of MAOB activity may improve the quality of life of the elderly and it is used as part of the treatment of Parkinson’s patients. MATERIALS AND METHODS : Healthy, adult Wistar rats of both sexes (180-220g) were obtained from the Central animal house facility from Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu. The animals were kept in a well ventilated room and the animals had exposed to 12 hrs day and night cycle with a temperature between 20±30C. The animals were housed in large spacious, hygienic polypropylene cages during the course of the experimental period. The animals were fed with water and rat feed adlibitum. All experiments were performed after obtaining prior approval from CPCSEA and IAEC. The animals were housed in suitable environmental conditions. Approval no: 1143/ac/07/CPCSEA/PCP/IAEC/PhD/132/12 Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi were collected from local vender from Coimbatore district, Tamilnadu, India. The collected plants were authentified by Dr. S Rajan, Field Botanist, Survey of Medicinal Plants & Collection Unit, Central Council for Research in Homoeopathy, Dept. of AYUSH, The Nilgiris, Tamilnadu. INFERENCES : The efficacy of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in 6-OHDA induced PD has not been well established. In our study, we have demonstrated the anti-Parkinson’s activity of not only the above mentioned three plant extract but also evaluated the combined effects of all three extracts. In this study, first we have demonstrated the Apomorphne induced circling behavior. Apomorphne is a mixed (D1 and D2) dopamine receptor agonist that does not share transport or metabolic pathways with L-DOPA and presumably acts by direct stimulation of dopamine receptor. In our study, the circling controversial to the lesion side following the administration of LDOPA or dopamine agonist result from stimulation of dopamine receptor rendered supersensitive by partial denervation. The lesioned rats showed a greater level of circling behavior and other treatment groups might be replenishing dopamine or already protected dopaminergic nurons in mid brain (SNpc). Further it could presumably suggest the confirmation of nigral lesion in all the treatment groups. Anyhow, the significant levels in comparing the degree of lesioning is not mandatory in our study, because post treatment lesion verification. CONCLUSION : In view of the above facts we are concluding that Uncaria rhynchophylla, Mentha aquatic and Banisteriopsis caapi- plants showed significant anti-Parkinson’s activity, and earlier these plants were ethanopharmacologically proven for its anti oxidant, anti ulcer, antiseptic, antispasmodic, anti diabetic, immunostimulent, anti cancer and CNS activities. The evaluation of anti Parkinson’s activities of these plants might be leading to a new drug molecule or herbal moiety which can ameliorate the anti-Parkinson’s drug toxicities or can be an anti Parkinson’s drug in future. The anti-Parkinson’s activity of herbal extracts was performed. The extracts showed significant anti-Parkinson’s activity in 6-OHDA lesioned rat models. The estimated parameters were closely relevant to clinical Parkinsonism and the drug treatment protected the diseased brain of rat. And we appreciate further detailed molecular studies with these drugs in anti-Parkinson’s pharmacology and toxicology. From these findings we suggest that, these drug molecules can be a future drug of choice for the treatment of clinical Parkinsonism.
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evaluation of antiparkinson s activity of uncaria rhynchophylla mentha aquatica and Banisteriopsis caapi plants with monoamine oxidase b mao b inhibition potential
2015Co-Authors: Pal BiswajitAbstract:INTRODUCTION : Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of mesencephalic dopaminergic neurons in the substantia nigra innervating the striatum. It was first described by neurologist James Parkinson in 1817 that he called ‘‘Shaking Palsy’’, or ‘‘paralysis agitans’’. The causes are unknown although risk factors in the genetic and toxic domain are being discovered. An important pathophysiological feature in PD is the loss of part of the dopaminergic neurons in the substantia nigra (SN) resulting in a specific dysorganisation of the complicated basal ganglia (BG) circuits. The relay functions at the level of the striatum e.g., are out of balance leading to disturbed subcorticocortical interactions. Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily affecting people of ages over 55 years (approximately 1.5% to 2.0%), although young adults and even children can also be affected. Research on the pathogenesis of PD has rapidly advanced due to the development of animal models. Through the use of these models, the striatal dopamine deficiency could be associated with the motor symptoms of PD, and levodopa (dihydroxyphenylalanine or L-dopa) was first applied to compensate striatal dopamine losses. L-Dopa treatment still remains the standard of PD therapies. Unfortunately, long-time use of L-dopa results in dyskinesia (involuntary movements). Moreover, the specific etiology of PD is still unknown. Thus, the development of animal models is essential for better understanding pathogenesis and progression of PD and testing therapeutic agents for the treatment of PD patients. AIM OF THE RESEARCH : • To investigate whether monoamine oxidase-B (MAO-B) inhibition potential plants [Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi] protects brain against neurodegenaration in 6-OHDA rat models, and to analyse the murine preclinical therapeutic efficacy of test drugs in attaining postural stability after completion of treatment. • To explore the beneficial effects of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in reducing neurodegenaration by controlling iron induced neurotoxicity, retaining dopamine concentrations and lowered oxidative stress in experimental PD. • To study the effectiveness of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi for neuroprotection in PD model through controlling MAO-B associated pathways of metabolism. OBJECTIVE : In the present study, we would like to evaluate the possible Anti-Parkinson’s activity of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi plants which are showing monoamine oxidase-B (MAO-B) inhibition and anti-oxidant activity and to find out the possible actions of these plants for alleviating or preventing the neurodegeneration and mitochondrial dysfunction for the treatment of Parkinson’s disease. Monoamine oxidase (MAO), a flavin-containing enzyme, is widely distributed in both the central and peripheral nervous systems20 and plays a central role in the control of substrate availability and activity. MAO catalyzes the oxidation of a variety of amine-containing neurotransmitters to yield the corresponding aldehyde, hydrogen peroxide (H2O2), and ammonia17. MAO exists in two forms, MAO-A and MAO-B, which are distinguished on the basis of different pharmacological and biochemical characteristics. MAO is a key enzyme in catecholamine metabolism, and increased catecholamine metabolism seen in aging has been extensively studied. The control on MAO activity may alleviate symptoms and slow the progression of neurodegenerative disorders. In humans, MAO-B activity increases with age18 and is especially elevated in certain neurodegenerative diseases19. Therefore, inhibition of MAOB activity may improve the quality of life of the elderly and it is used as part of the treatment of Parkinson’s patients. MATERIALS AND METHODS : Healthy, adult Wistar rats of both sexes (180-220g) were obtained from the Central animal house facility from Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu. The animals were kept in a well ventilated room and the animals had exposed to 12 hrs day and night cycle with a temperature between 20±30C. The animals were housed in large spacious, hygienic polypropylene cages during the course of the experimental period. The animals were fed with water and rat feed adlibitum. All experiments were performed after obtaining prior approval from CPCSEA and IAEC. The animals were housed in suitable environmental conditions. Approval no: 1143/ac/07/CPCSEA/PCP/IAEC/PhD/132/12 Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi were collected from local vender from Coimbatore district, Tamilnadu, India. The collected plants were authentified by Dr. S Rajan, Field Botanist, Survey of Medicinal Plants & Collection Unit, Central Council for Research in Homoeopathy, Dept. of AYUSH, The Nilgiris, Tamilnadu. INFERENCES : The efficacy of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in 6-OHDA induced PD has not been well established. In our study, we have demonstrated the anti-Parkinson’s activity of not only the above mentioned three plant extract but also evaluated the combined effects of all three extracts. In this study, first we have demonstrated the Apomorphne induced circling behavior. Apomorphne is a mixed (D1 and D2) dopamine receptor agonist that does not share transport or metabolic pathways with L-DOPA and presumably acts by direct stimulation of dopamine receptor. In our study, the circling controversial to the lesion side following the administration of LDOPA or dopamine agonist result from stimulation of dopamine receptor rendered supersensitive by partial denervation. The lesioned rats showed a greater level of circling behavior and other treatment groups might be replenishing dopamine or already protected dopaminergic nurons in mid brain (SNpc). Further it could presumably suggest the confirmation of nigral lesion in all the treatment groups. Anyhow, the significant levels in comparing the degree of lesioning is not mandatory in our study, because post treatment lesion verification. CONCLUSION : In view of the above facts we are concluding that Uncaria rhynchophylla, Mentha aquatic and Banisteriopsis caapi- plants showed significant anti-Parkinson’s activity, and earlier these plants were ethanopharmacologically proven for its anti oxidant, anti ulcer, antiseptic, antispasmodic, anti diabetic, immunostimulent, anti cancer and CNS activities. The evaluation of anti Parkinson’s activities of these plants might be leading to a new drug molecule or herbal moiety which can ameliorate the anti-Parkinson’s drug toxicities or can be an anti Parkinson’s drug in future. The anti-Parkinson’s activity of herbal extracts was performed. The extracts showed significant anti-Parkinson’s activity in 6-OHDA lesioned rat models. The estimated parameters were closely relevant to clinical Parkinsonism and the drug treatment protected the diseased brain of rat. And we appreciate further detailed molecular studies with these drugs in anti-Parkinson’s pharmacology and toxicology. From these findings we suggest that, these drug molecules can be a future drug of choice for the treatment of clinical Parkinsonism.
-
Evaluation of Antiparkinson’s activity of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi-plants with Monoamine Oxidase-B (MAO-B) inhibition potential.
2015Co-Authors: Pal BiswajitAbstract:INTRODUCTION : Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of mesencephalic dopaminergic neurons in the substantia nigra innervating the striatum. It was first described by neurologist James Parkinson in 1817 that he called ‘‘Shaking Palsy’’, or ‘‘paralysis agitans’’. The causes are unknown although risk factors in the genetic and toxic domain are being discovered. An important pathophysiological feature in PD is the loss of part of the dopaminergic neurons in the substantia nigra (SN) resulting in a specific dysorganisation of the complicated basal ganglia (BG) circuits. The relay functions at the level of the striatum e.g., are out of balance leading to disturbed subcorticocortical interactions. Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily affecting people of ages over 55 years (approximately 1.5% to 2.0%), although young adults and even children can also be affected. Research on the pathogenesis of PD has rapidly advanced due to the development of animal models. Through the use of these models, the striatal dopamine deficiency could be associated with the motor symptoms of PD, and levodopa (dihydroxyphenylalanine or L-dopa) was first applied to compensate striatal dopamine losses. L-Dopa treatment still remains the standard of PD therapies. Unfortunately, long-time use of L-dopa results in dyskinesia (involuntary movements). Moreover, the specific etiology of PD is still unknown. Thus, the development of animal models is essential for better understanding pathogenesis and progression of PD and testing therapeutic agents for the treatment of PD patients. AIM OF THE RESEARCH : • To investigate whether monoamine oxidase-B (MAO-B) inhibition potential plants [Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi] protects brain against neurodegenaration in 6-OHDA rat models, and to analyse the murine preclinical therapeutic efficacy of test drugs in attaining postural stability after completion of treatment. • To explore the beneficial effects of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in reducing neurodegenaration by controlling iron induced neurotoxicity, retaining dopamine concentrations and lowered oxidative stress in experimental PD. • To study the effectiveness of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi for neuroprotection in PD model through controlling MAO-B associated pathways of metabolism. OBJECTIVE : In the present study, we would like to evaluate the possible Anti-Parkinson’s activity of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi plants which are showing monoamine oxidase-B (MAO-B) inhibition and anti-oxidant activity and to find out the possible actions of these plants for alleviating or preventing the neurodegeneration and mitochondrial dysfunction for the treatment of Parkinson’s disease. Monoamine oxidase (MAO), a flavin-containing enzyme, is widely distributed in both the central and peripheral nervous systems20 and plays a central role in the control of substrate availability and activity. MAO catalyzes the oxidation of a variety of amine-containing neurotransmitters to yield the corresponding aldehyde, hydrogen peroxide (H2O2), and ammonia17. MAO exists in two forms, MAO-A and MAO-B, which are distinguished on the basis of different pharmacological and biochemical characteristics. MAO is a key enzyme in catecholamine metabolism, and increased catecholamine metabolism seen in aging has been extensively studied. The control on MAO activity may alleviate symptoms and slow the progression of neurodegenerative disorders. In humans, MAO-B activity increases with age18 and is especially elevated in certain neurodegenerative diseases19. Therefore, inhibition of MAOB activity may improve the quality of life of the elderly and it is used as part of the treatment of Parkinson’s patients. MATERIALS AND METHODS : Healthy, adult Wistar rats of both sexes (180-220g) were obtained from the Central animal house facility from Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu. The animals were kept in a well ventilated room and the animals had exposed to 12 hrs day and night cycle with a temperature between 20±30C. The animals were housed in large spacious, hygienic polypropylene cages during the course of the experimental period. The animals were fed with water and rat feed adlibitum. All experiments were performed after obtaining prior approval from CPCSEA and IAEC. The animals were housed in suitable environmental conditions. Approval no: 1143/ac/07/CPCSEA/PCP/IAEC/PhD/132/12 Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi were collected from local vender from Coimbatore district, Tamilnadu, India. The collected plants were authentified by Dr. S Rajan, Field Botanist, Survey of Medicinal Plants & Collection Unit, Central Council for Research in Homoeopathy, Dept. of AYUSH, The Nilgiris, Tamilnadu. INFERENCES : The efficacy of Uncaria rhynchophylla, Mentha aquatica and Banisteriopsis caapi in 6-OHDA induced PD has not been well established. In our study, we have demonstrated the anti-Parkinson’s activity of not only the above mentioned three plant extract but also evaluated the combined effects of all three extracts. In this study, first we have demonstrated the Apomorphne induced circling behavior. Apomorphne is a mixed (D1 and D2) dopamine receptor agonist that does not share transport or metabolic pathways with L-DOPA and presumably acts by direct stimulation of dopamine receptor. In our study, the circling controversial to the lesion side following the administration of LDOPA or dopamine agonist result from stimulation of dopamine receptor rendered supersensitive by partial denervation. The lesioned rats showed a greater level of circling behavior and other treatment groups might be replenishing dopamine or already protected dopaminergic nurons in mid brain (SNpc). Further it could presumably suggest the confirmation of nigral lesion in all the treatment groups. Anyhow, the significant levels in comparing the degree of lesioning is not mandatory in our study, because post treatment lesion verification. CONCLUSION : In view of the above facts we are concluding that Uncaria rhynchophylla, Mentha aquatic and Banisteriopsis caapi- plants showed significant anti-Parkinson’s activity, and earlier these plants were ethanopharmacologically proven for its anti oxidant, anti ulcer, antiseptic, antispasmodic, anti diabetic, immunostimulent, anti cancer and CNS activities. The evaluation of anti Parkinson’s activities of these plants might be leading to a new drug molecule or herbal moiety which can ameliorate the anti-Parkinson’s drug toxicities or can be an anti Parkinson’s drug in future. The anti-Parkinson’s activity of herbal extracts was performed. The extracts showed significant anti-Parkinson’s activity in 6-OHDA lesioned rat models. The estimated parameters were closely relevant to clinical Parkinsonism and the drug treatment protected the diseased brain of rat. And we appreciate further detailed molecular studies with these drugs in anti-Parkinson’s pharmacology and toxicology. From these findings we suggest that, these drug molecules can be a future drug of choice for the treatment of clinical Parkinsonism.
Nawo Eguchi - One of the best experts on this subject based on the ideXlab platform.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen beta-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by beta-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their duration of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of beta-carbolines in the brain. The smaller ED50 values of beta-carbolines that cause tremors/convulsions showed lower levels of beta-carbolines in brain tissue.
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Relationship between occurrence of tremor/convulsion and level of β-carbolines in the brain after administration of β-carbolines into mice
Pharmacology Biochemistry and Behavior, 1994Co-Authors: Kazuko Kawanishi, Nawo Eguchi, Y. HashimotoAbstract:Fifteen β-carboline derivatives, including those found in the South American hallucinogenic plant Banisteriopsis caapi, were injected IP and IVC into mice. Subsequent behavioral changes were observed and the levels of the compounds in brain tissue were determined. It was found that following IP administration, tremors and/or convulsions were induced by β-carbolines having aliphatic alkyl groups, but not by those with carbonyl and oxo groups substituted at carbon-1 of the C ring. These effects were potentiated by the presence of a methoxy group at carbon-7 of the A ring, and their durations of actions were prolonged by 3,4-dihydro derivatives. When induced, tremors/convulsions correlated with levels of β-carbolines in the brain. The smaller ED50 values of β-carbolines that cause tremors/convulsions showed lower levels of β-carbolines in brain tissue.
