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Andrew M Taylor - One of the best experts on this subject based on the ideXlab platform.

Philipp Lurz - One of the best experts on this subject based on the ideXlab platform.

Gerhard Schuler - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of Bare-Metal Stenting With Minimally Invasive Bypass Surgery for Stenosis of the Left Anterior Descending Coronary Artery: 10-Year Follow-Up of a Randomized Trial
    JACC. Cardiovascular interventions, 2013
    Co-Authors: Stephan Blazek, Philipp Lurz, Cornelius Rossbach, Michael A. Borger, Georg Fuernau, Steffen Desch, Ingo Eitel, T Stiermaier, David Holzhey, Gerhard Schuler
    Abstract:

    Objectives The aim of this prospective, randomized trial was to assess the 10-year long-term safety and effectiveness of percutaneous coronary intervention (PCI) and minimally invasive direct coronary artery bypass surgery (MIDCAB) for the treatment of proximal left anterior descending (LAD) lesions. Background Long-term follow-up data comparing PCI and MIDCAB surgery for isolated proximal LAD lesions are sparse. Methods Patients with significant isolated proximal LAD stenoses were randomized either to PCI with Bare-Metal stents (n = 110) or MIDCAB (n = 110). At 10 years, data were obtained with respect to the primary endpoint (death, myocardial infarction, target vessel revascularization). Angina was assessed by the Canadian Cardiovascular Society classification. Results Follow-up was conducted for 212 patients at a median time of 10.3 years. There were no significant differences in the binary primary composite endpoint (47% vs. 36%; p = 0.12) and hard endpoints (death and infarction) between PCI and MIDCAB. However, a higher target vessel revascularization rate in the PCI group (34% vs. 11%; p Conclusions At 10-year follow-up, PCI and MIDCAB in isolated proximal LAD lesions yielded similar long-term outcomes regarding the primary composite clinical endpoint. Target vessel revascularization was more frequent in the PCI group.

  • randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus eluting Stenting in isolated proximal left anterior descending coronary artery stenosis
    Journal of the American College of Cardiology, 2009
    Co-Authors: Holger Thiele, Friedrich W Mohr, Gerhard Schuler, Stephan Jacobs, Patrick Neumannschniedewind, Enno Boudriot, Thomas Walther, Volkmar Falk
    Abstract:

    Objectives The purpose of this randomized study was to compare sirolimus-eluting Stenting (SES) with minimally invasive direct coronary artery bypass (MIDCAB) surgery for patients with isolated proximal left anterior descending (LAD) coronary artery disease. Background Bare-Metal Stenting is inferior to MIDCAB surgery in patients with isolated proximal LAD lesions due to a higher reintervention rate with similar results for mortality and reinfarction. SES are effective in restenosis reduction. Methods A total of 130 patients with significant proximal LAD coronary artery disease were randomized to either SES (n = 65) or MIDCAB surgery (n = 65). The primary clinical end point was noninferiority in freedom from major adverse cardiac events (MACE), such as cardiac death, myocardial infarction, and the need for target vessel revascularization within 12 months. Results Follow-up was completed for all patients. MACE occurred in 7.7% of patients after Stenting, as compared with 7.7% after surgery (p = 0.03 for noninferiority). The individual components of the combined end point revealed mixed results. Although noninferiority was revealed for the difference in death and myocardial infarction (1.5% vs. 7.7%, noninferiority p Conclusions In isolated proximal LAD disease, SES is noninferior to MIDCAB surgery at 12-month follow-up with respect to MACE at a similar relief in clinical symptoms. (MIDCAB Versus DES in Proximal LAD Lesions; NCT00299429 )

  • comparison of Bare Metal Stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery a 5 year follow up
    Circulation, 2005
    Co-Authors: Holger Thiele, Rainer Hambrecht, Peter Sick, Friedrich W Mohr, Gerhard Schuler, Stefan Oettel, Stephan Jacobs, Jan F Gummert, Volkmar Falk
    Abstract:

    Background— Randomized trials comparing Stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for Stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse. Methods and Results— Patients with isolated proximal left anterior descending stenosis were randomized to either surgery (n=110) or Bare-Metal Stenting (n=110). At 5 years, follow-up data were obtained with respect to the primary end point of death, reinfarction, or repeated target vessel revascularization. Clinical symptoms were assessed by the Canadian Cardiovascular Society (CCS) classification. Follow-up information was completed for 216 patients (98.2%), and mean follow-up was 5.6±1.2 years. With respect to mortality (surgery, 12%; Stenting, 10%; P =0.54) and reinfarctions (surgery, 7%; Stenting, 5%; P =0.46), there were no differences between treatment strategies. The need for repeated target vessel revascularization was significantly higher after Stenting (32%) compared with surgery (10%; P P P P =0.05, Stenting versus surgery). Conclusions— At the 5-year follow-up, minimally invasive bypass surgery and Bare-Metal Stenting showed similar results for the end points of mortality and reinfarctions. However, the reintervention rate is higher after Stenting, and the relief in clinical symptoms is slightly better after surgery.

  • comparison of Stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    The New England Journal of Medicine, 2002
    Co-Authors: Anno Diegeler, Holger Thiele, Volkmar Falk, Rainer Hambrecht, Niki Spyrantis, Peter Sick, Klaus Diederich, Friedrich W Mohr, Gerhard Schuler
    Abstract:

    Background— Randomized trials comparing Stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for Stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse. Methods and Results— Patients with isolated proximal left anterior descending stenosis were randomized to either surgery (n=110) or Bare-Metal Stenting (n=110). At 5 years, follow-up data were obtained with respect to the primary end point of death, reinfarction, or repeated target vessel revascularization. Clinical symptoms were assessed by the Canadian Cardiovascular Society (CCS) classification. Follow-up information was completed for 216 patients (98.2%), and mean follow-up was 5.6±1.2 years. With respect to mortality (surgery, 12%; Stenting, 10%; P=0.54) and reinfarctions (surgery, 7%; Stenting, 5%; P=0.46), there were no differences between treatm...

Sachin Khambadkone - One of the best experts on this subject based on the ideXlab platform.

Volkmar Falk - One of the best experts on this subject based on the ideXlab platform.

  • randomized comparison of minimally invasive direct coronary artery bypass surgery versus sirolimus eluting Stenting in isolated proximal left anterior descending coronary artery stenosis
    Journal of the American College of Cardiology, 2009
    Co-Authors: Holger Thiele, Friedrich W Mohr, Gerhard Schuler, Stephan Jacobs, Patrick Neumannschniedewind, Enno Boudriot, Thomas Walther, Volkmar Falk
    Abstract:

    Objectives The purpose of this randomized study was to compare sirolimus-eluting Stenting (SES) with minimally invasive direct coronary artery bypass (MIDCAB) surgery for patients with isolated proximal left anterior descending (LAD) coronary artery disease. Background Bare-Metal Stenting is inferior to MIDCAB surgery in patients with isolated proximal LAD lesions due to a higher reintervention rate with similar results for mortality and reinfarction. SES are effective in restenosis reduction. Methods A total of 130 patients with significant proximal LAD coronary artery disease were randomized to either SES (n = 65) or MIDCAB surgery (n = 65). The primary clinical end point was noninferiority in freedom from major adverse cardiac events (MACE), such as cardiac death, myocardial infarction, and the need for target vessel revascularization within 12 months. Results Follow-up was completed for all patients. MACE occurred in 7.7% of patients after Stenting, as compared with 7.7% after surgery (p = 0.03 for noninferiority). The individual components of the combined end point revealed mixed results. Although noninferiority was revealed for the difference in death and myocardial infarction (1.5% vs. 7.7%, noninferiority p Conclusions In isolated proximal LAD disease, SES is noninferior to MIDCAB surgery at 12-month follow-up with respect to MACE at a similar relief in clinical symptoms. (MIDCAB Versus DES in Proximal LAD Lesions; NCT00299429 )

  • comparison of Bare Metal Stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery a 5 year follow up
    Circulation, 2005
    Co-Authors: Holger Thiele, Rainer Hambrecht, Peter Sick, Friedrich W Mohr, Gerhard Schuler, Stefan Oettel, Stephan Jacobs, Jan F Gummert, Volkmar Falk
    Abstract:

    Background— Randomized trials comparing Stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for Stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse. Methods and Results— Patients with isolated proximal left anterior descending stenosis were randomized to either surgery (n=110) or Bare-Metal Stenting (n=110). At 5 years, follow-up data were obtained with respect to the primary end point of death, reinfarction, or repeated target vessel revascularization. Clinical symptoms were assessed by the Canadian Cardiovascular Society (CCS) classification. Follow-up information was completed for 216 patients (98.2%), and mean follow-up was 5.6±1.2 years. With respect to mortality (surgery, 12%; Stenting, 10%; P =0.54) and reinfarctions (surgery, 7%; Stenting, 5%; P =0.46), there were no differences between treatment strategies. The need for repeated target vessel revascularization was significantly higher after Stenting (32%) compared with surgery (10%; P P P P =0.05, Stenting versus surgery). Conclusions— At the 5-year follow-up, minimally invasive bypass surgery and Bare-Metal Stenting showed similar results for the end points of mortality and reinfarctions. However, the reintervention rate is higher after Stenting, and the relief in clinical symptoms is slightly better after surgery.

  • comparison of Stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery
    The New England Journal of Medicine, 2002
    Co-Authors: Anno Diegeler, Holger Thiele, Volkmar Falk, Rainer Hambrecht, Niki Spyrantis, Peter Sick, Klaus Diederich, Friedrich W Mohr, Gerhard Schuler
    Abstract:

    Background— Randomized trials comparing Stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for Stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse. Methods and Results— Patients with isolated proximal left anterior descending stenosis were randomized to either surgery (n=110) or Bare-Metal Stenting (n=110). At 5 years, follow-up data were obtained with respect to the primary end point of death, reinfarction, or repeated target vessel revascularization. Clinical symptoms were assessed by the Canadian Cardiovascular Society (CCS) classification. Follow-up information was completed for 216 patients (98.2%), and mean follow-up was 5.6±1.2 years. With respect to mortality (surgery, 12%; Stenting, 10%; P=0.54) and reinfarctions (surgery, 7%; Stenting, 5%; P=0.46), there were no differences between treatm...