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Basal Ganglion Loop

The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform

Hannah Monyer – 1st expert on this subject based on the ideXlab platform

  • Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity
    Cell Reports, 2017
    Co-Authors: Sarah Melzer, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer

    Abstract:

    The motor cortico-Basal Ganglion Loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this Loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM+) and parvalbumin-positive (PV+) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV+ and M2 SOM+ projecting neurons reduced locomotion, whereas stimulation of M1 SOM+ projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.

Sarah Melzer – 2nd expert on this subject based on the ideXlab platform

  • Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity
    Cell Reports, 2017
    Co-Authors: Sarah Melzer, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer

    Abstract:

    The motor cortico-Basal Ganglion Loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this Loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM+) and parvalbumin-positive (PV+) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV+ and M2 SOM+ projecting neurons reduced locomotion, whereas stimulation of M1 SOM+ projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.

Kee Wui Huang – 3rd expert on this subject based on the ideXlab platform

  • Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity
    Cell Reports, 2017
    Co-Authors: Sarah Melzer, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer

    Abstract:

    The motor cortico-Basal Ganglion Loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this Loop is crucial for proper motor output. Excitatory neurons have been thought to be the only source of motor cortical input to the striatum. Here, we identify long-range projecting GABAergic neurons in the primary (M1) and secondary (M2) motor cortex that target the dorsal striatum. This population of projecting GABAergic neurons comprises both somatostatin-positive (SOM+) and parvalbumin-positive (PV+) neurons that target direct and indirect pathway striatal output neurons as well as cholinergic interneurons differentially. Notably, optogenetic stimulation of M1 PV+ and M2 SOM+ projecting neurons reduced locomotion, whereas stimulation of M1 SOM+ projecting neurons enhanced locomotion. Thus, corticostriatal GABAergic projections modulate striatal output and motor activity.