The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform

Giancarlo Fabrizi - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and functionalization of indoles through palladium catalyzed reactions
    Chemical Reviews, 2005
    Co-Authors: Sandro Cacchi, Giancarlo Fabrizi
    Abstract:

    The substituted indole nucleus [indole is the acronym from indigo (the natural dye) and oleum (used for the isolation)] is a structural component of a vast number of biologically active natural and unnatural compounds. The Synthesis and functionalization of indoles has been the object of research for over 100 years, and a variety of well-established classical methods are now available, to name a few of them, the Fisher indole Synthesis, the Gassman Synthesis of indoles from N-halo-anilines, the Madelung cyclization of N-acyl-o-toluidines, the Bischler indole Synthesis, the Batcho-Leimgruber Synthesis of indoles from o-nitrotoluenes and dimethylformamide acetals, and the reductive cyclization of o-nitrobenzyl ketones.1 In the last 40 years or so, however, palladiumcatalyzed reactions, generally tolerant of a wide range of functionalities and therefore applicable to complex molecules, have achieved an important place in the arsenal of the practicing organic chemist. Since the invention of an industrial process for the palladium-catalyzed production of acetaldehyde from ethylene in the presence of PdCl2 and CuCl2, an everincreasing number of organic transformations have been based on palladium catalysis. Almost every area of the organic Synthesis has been deeply influenced by the profound potential of this versatile transition metal, modifying the way organic chemists design and realize synthetic processes.2,3 Because of its catalytic nature, palladium-catalyzed Synthesis can provide access to fine chemicals, agrochemical and pharmaceutical intermediates, and active ingredients in fewer steps and with less waste than classical † In memory of Prof. Bianca Rosa Pietroni, a colleague and very close friend. * To whom correspondence should be addressed. Phone: + 39 (06) 4991-2785. Fax: + 30 (06) 4991-2780. E-mail: sandro.cacchi@ uniroma1.it. 2873 Chem. Rev. 2005, 105, 2873−2920

Sandro Cacchi - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis and functionalization of indoles through palladium catalyzed reactions
    Chemical Reviews, 2005
    Co-Authors: Sandro Cacchi, Giancarlo Fabrizi
    Abstract:

    The substituted indole nucleus [indole is the acronym from indigo (the natural dye) and oleum (used for the isolation)] is a structural component of a vast number of biologically active natural and unnatural compounds. The Synthesis and functionalization of indoles has been the object of research for over 100 years, and a variety of well-established classical methods are now available, to name a few of them, the Fisher indole Synthesis, the Gassman Synthesis of indoles from N-halo-anilines, the Madelung cyclization of N-acyl-o-toluidines, the Bischler indole Synthesis, the Batcho-Leimgruber Synthesis of indoles from o-nitrotoluenes and dimethylformamide acetals, and the reductive cyclization of o-nitrobenzyl ketones.1 In the last 40 years or so, however, palladiumcatalyzed reactions, generally tolerant of a wide range of functionalities and therefore applicable to complex molecules, have achieved an important place in the arsenal of the practicing organic chemist. Since the invention of an industrial process for the palladium-catalyzed production of acetaldehyde from ethylene in the presence of PdCl2 and CuCl2, an everincreasing number of organic transformations have been based on palladium catalysis. Almost every area of the organic Synthesis has been deeply influenced by the profound potential of this versatile transition metal, modifying the way organic chemists design and realize synthetic processes.2,3 Because of its catalytic nature, palladium-catalyzed Synthesis can provide access to fine chemicals, agrochemical and pharmaceutical intermediates, and active ingredients in fewer steps and with less waste than classical † In memory of Prof. Bianca Rosa Pietroni, a colleague and very close friend. * To whom correspondence should be addressed. Phone: + 39 (06) 4991-2785. Fax: + 30 (06) 4991-2780. E-mail: sandro.cacchi@ uniroma1.it. 2873 Chem. Rev. 2005, 105, 2873−2920

Sharpe, David Anthony. - One of the best experts on this subject based on the ideXlab platform.

  • Synthetic studies towards ergot alkaloids.
    Sheffield Hallam University, 1
    Co-Authors: Sharpe, David Anthony.
    Abstract:

    Some of the background to the bioSynthesis, Synthesis and uses of ergot alkaloids has been reviewed.A novel Synthesis of the indole system has been used in an attempt to Synthesise a derivative of the tricyclic Uhles ketone. A variation on this method has been carried out using 3-indole propionic acid as the starting material. The novel Synthesis of the indole ring system has been developed into a Synthesis of a 4-substituted indole.A number of literature methods for the Synthesis of 4-substituted indoles have been investigated, and their usefulness in the laboratory assessed. A modified Reissert Synthesis has been carried out, along with a Batcho-Leimgruber Synthesis. Also the use of a thallium based method and palladium catalysed carbon-carbon bond formation have been investigated.A novel Synthesis of p-benzoquinones has been discovered, by oxidation of aromatic sulphonamides. This method has not been optimised but low to moderate yields of quinones have been achieved. This method was used in an attempt to Synthesise o-benzoquinones, but was found to be unsuitable.A novel Synthesis of aromatic thiol esters has been developed starting from simple substituted benzaldehydes esters and methylmethylthiomethylsulphoxide. The resulting ketene thioacetal monosulphoxide was treated under the same conditions as those used in the novel indole Synthesis. High yields of thiolesters were obtained