The Experts below are selected from a list of 49863 Experts worldwide ranked by ideXlab platform
Nicolas Marjanovic - One of the best experts on this subject based on the ideXlab platform.
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Bench-Test comparison of 26 emergency and transport ventilators
Critical Care, 2014Co-Authors: Erwan L'her, Annie Roy, Nicolas MarjanovicAbstract:INTRODUCTION: Numerous emergency and transport ventilators are commercialized and new generations arise constantly. The aim of this study was to evaluate a large panel of ventilators to allow clinicians to choose a device, taking into account their specificities of use. METHODS: This experimental Bench-Test took into account general characteristics and technical performances. Performances were assessed under different levels of FIO2 (100%, 50% or Air-Mix), respiratory mechanics (compliance 30,70,120 mL/cmH2O; resistance 5,10,20 cmH2O/mL/s), and levels of leaks (3.5 to 12.5 L/min), using a Test lung. RESULTS: In total 26 emergency and transport ventilators were analyzed and classified into four categories (ICU-like, n = 5; Sophisticated, n = 10; Simple, n = 9; Mass-casualty and military, n = 2). Oxygen consumption (7.1 to 15.8 L/min at FIO2 100%) and the Air-Mix mode (FIO2 45 to 86%) differed from one device to the other. Triggering performance was heterogeneous, but several sophisticated ventilators depicted triggering capabilities as efficient as ICU-like ventilators. Pressurization was not adequate for all devices. At baseline, all the ventilators were able to synchronize, but with variations among respiratory conditions. Leak compensation in most ICU-like and 4/10 sophisticated devices was able to correct at least partially for system leaks, but with variations among ventilators. CONCLUSION: Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.
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Bench Test comparison of 26 emergency and transport ventilators
Critical Care, 2014Co-Authors: Erwan Lher, Annie Roy, Nicolas MarjanovicAbstract:Numerous emergency and transport ventilators are commercialized and new generations arise constantly. The aim of this study was to evaluate a large panel of ventilators to allow clinicians to choose a device, taking into account their specificities of use. This experimental Bench-Test took into account general characteristics and technical performances. Performances were assessed under different levels of FIO2 (100%, 50% or Air-Mix), respiratory mechanics (compliance 30,70,120 mL/cmH2O; resistance 5,10,20 cmH2O/mL/s), and levels of leaks (3.5 to 12.5 L/min), using a Test lung. In total 26 emergency and transport ventilators were analyzed and classified into four categories (ICU-like, n = 5; Sophisticated, n = 10; Simple, n = 9; Mass-casualty and military, n = 2). Oxygen consumption (7.1 to 15.8 L/min at FIO2 100%) and the Air-Mix mode (FIO2 45 to 86%) differed from one device to the other. Triggering performance was heterogeneous, but several sophisticated ventilators depicted triggering capabilities as efficient as ICU-like ventilators. Pressurization was not adequate for all devices. At baseline, all the ventilators were able to synchronize, but with variations among respiratory conditions. Leak compensation in most ICU-like and 4/10 sophisticated devices was able to correct at least partially for system leaks, but with variations among ventilators. Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.
Akihiro Suzuki - One of the best experts on this subject based on the ideXlab platform.
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crt 160 influence of stent length on stent deliverability between first and second generation drug eluting stent platform using Bench Test model
Jacc-cardiovascular Interventions, 2015Co-Authors: Katsuhisa Waseda, Hiroaki Takashima, Masanobu Fujimoto, Yasuo Kuroda, Takashi Kosaka, Akiyoshi Kurita, Hirohiko Ando, Kazuyuki Maeda, Shinichiro Sakurai, Akihiro SuzukiAbstract:While drug-eluting stents (DES) have recently improved their efficacy and safety profiles, differences in stent deliverability among various coronary stents have not been systematically evaluated. The aim of this Bench Test study was to evaluate the impact of stent length on stent deliverability
Annie Roy - One of the best experts on this subject based on the ideXlab platform.
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Bench-Test comparison of 26 emergency and transport ventilators
Critical Care, 2014Co-Authors: Erwan L'her, Annie Roy, Nicolas MarjanovicAbstract:INTRODUCTION: Numerous emergency and transport ventilators are commercialized and new generations arise constantly. The aim of this study was to evaluate a large panel of ventilators to allow clinicians to choose a device, taking into account their specificities of use. METHODS: This experimental Bench-Test took into account general characteristics and technical performances. Performances were assessed under different levels of FIO2 (100%, 50% or Air-Mix), respiratory mechanics (compliance 30,70,120 mL/cmH2O; resistance 5,10,20 cmH2O/mL/s), and levels of leaks (3.5 to 12.5 L/min), using a Test lung. RESULTS: In total 26 emergency and transport ventilators were analyzed and classified into four categories (ICU-like, n = 5; Sophisticated, n = 10; Simple, n = 9; Mass-casualty and military, n = 2). Oxygen consumption (7.1 to 15.8 L/min at FIO2 100%) and the Air-Mix mode (FIO2 45 to 86%) differed from one device to the other. Triggering performance was heterogeneous, but several sophisticated ventilators depicted triggering capabilities as efficient as ICU-like ventilators. Pressurization was not adequate for all devices. At baseline, all the ventilators were able to synchronize, but with variations among respiratory conditions. Leak compensation in most ICU-like and 4/10 sophisticated devices was able to correct at least partially for system leaks, but with variations among ventilators. CONCLUSION: Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.
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Bench Test comparison of 26 emergency and transport ventilators
Critical Care, 2014Co-Authors: Erwan Lher, Annie Roy, Nicolas MarjanovicAbstract:Numerous emergency and transport ventilators are commercialized and new generations arise constantly. The aim of this study was to evaluate a large panel of ventilators to allow clinicians to choose a device, taking into account their specificities of use. This experimental Bench-Test took into account general characteristics and technical performances. Performances were assessed under different levels of FIO2 (100%, 50% or Air-Mix), respiratory mechanics (compliance 30,70,120 mL/cmH2O; resistance 5,10,20 cmH2O/mL/s), and levels of leaks (3.5 to 12.5 L/min), using a Test lung. In total 26 emergency and transport ventilators were analyzed and classified into four categories (ICU-like, n = 5; Sophisticated, n = 10; Simple, n = 9; Mass-casualty and military, n = 2). Oxygen consumption (7.1 to 15.8 L/min at FIO2 100%) and the Air-Mix mode (FIO2 45 to 86%) differed from one device to the other. Triggering performance was heterogeneous, but several sophisticated ventilators depicted triggering capabilities as efficient as ICU-like ventilators. Pressurization was not adequate for all devices. At baseline, all the ventilators were able to synchronize, but with variations among respiratory conditions. Leak compensation in most ICU-like and 4/10 sophisticated devices was able to correct at least partially for system leaks, but with variations among ventilators. Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting.
C Danan - One of the best experts on this subject based on the ideXlab platform.
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continuous tracheal gas insufflation enables a volume reduction strategy in hyaline membrane disease technical aspects and clinical results
Intensive Care Medicine, 1998Co-Authors: G Dassieu, L Brochard, E Agudze, J Patkai, J C Janaud, C DananAbstract:Objective: Instrumental dead space wash-out can be used to improve carbon dioxide clearance. The aim of this study was to define, using a Bench Test, an optimal protocol for long-term use, and to assess the efficacy of this technique in neonates. Design: A Bench Test with an artificial lung model, and an observational prospective study. Dead space wash-out was performed by continuous tracheal gas insufflation (CTGI), via six capillaries molded in the wall of a specially designed endotracheal tube, in 30 preterm neonates with hyaline membrane disease. Setting: Neonatal intensive care unit of a regional hospital. Results: The Bench Test study showed that a CTGI flow of 0.5 l/min had the optimal efficacy-to-side-effect ratio, resulting in a maximal or submaximal efficacy (93 to 100 %) without a marked increase in tracheal and CTGI circuit pressures. In the 30 newborns, 15 min of CTGI induced a significant fall in arterial carbon dioxide tension (PaCO2), from 45 ± 7 to 35 ± 5 mmHg (p = 0.0001), and in 14 patients allowed a reduction in the gradient between Peack inspirating pressure and positive end-expiratory pressure from 20.8 ± 4.6 to 14.4 ± 3.7 cmH2O (p < 0.0001) while keeping the transcutaneous partial pressure of carbon dioxide constant. As predicted by the Bench Test, the decrease in PaCO2 induced by CTGI correlated well with PaCO2 values before CTGI (r = 0.58, p < 0.002) and with instrumental dead space-to-tidal volume ratio (r = 0.54, p < 0.005). Conclusion: CTGI may be a useful adjunct to conventional ventilation in preterm neonates with respiratory disease, enabling an increase in CO2 clearance or a reduction in ventilatory pressure.
Ian Pollock - One of the best experts on this subject based on the ideXlab platform.
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Comparison of Bench Test results measuring the accuracy of peak flow meters
BMC Pulmonary Medicine, 2019Co-Authors: Cristiano Vanzeller, Andrew Williams, Ian PollockAbstract:BackgroundThe study evaluates and compares the accuracy of nine peak flow meters (“PFMs”) and spirometers that are currently available in Europe and have Conformité Européene (“CE”) marking. The CE marking is a manufacturer’s declaration that their product complies with European health regulations and it is a requirement for marketing medical devices in Europe.MethodsThe nine devices were selected as they all had received or were in the process of receiving CE approval in Europe and were readily obtainable. The devices were Bench Tested following the ISO 23747:2015 accuracy guidelines for medical devices measuring peak flow. All standards, including accuracy, from these guidelines must be met to obtain CE marking. This study was performed with a certified piston pump Testing apparatus. The apparatus chosen was the pulmonary waveform generator manufactured by Piston Medical Ltd. Using predefined flow (time) and volume (time) waveforms, peak flow meters and spirometers were Tested for validation and calibration. Three CE guideline Tests were utilised, and standards require that all three Tests are passed for the device to obtain certification.ResultsOf the nine devices that were Tested, two passed and seven failed. The devices that passed the Tests were the Smart Peak Flow® and the Mini Wright®.ConclusionsA high percentage of devices failed accuracy Testing in this study. This is a concern as the CE marking is a manufacturer’s certification documenting the accuracy, reliability and safety of devices. Of the seven devices that failed all have the CE marking. All Tested devices are on the market in Europe based upon studies conducted by each of the manufacturers. The data used to obtain CE certification of these devices, however, are not in the public domain.