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J.g. Vogtländer - One of the best experts on this subject based on the ideXlab platform.

  • LCA Benchmarking Study on textiles made of cotton, polyester, nylon, acryl, or elastane
    The International Journal of Life Cycle Assessment, 2014
    Co-Authors: Natascha M. Velden, Martin Kumar Patel, J.g. Vogtländer
    Abstract:

    Purpose The purpose of this paper is to provide an improved (up-to-date) insight into the environmental burden of textiles made of the base materials cotton, polyester (PET), nylon, acryl, and elastane. The research question is: Which base material and which life cycle stage (cradle-to-gate as well as cradle-to-grave) have the biggest impact on the environment? Methods Life cycle inventory (LCI) data are collected from the literature, life cycle assessment (LCA) databases, and emission registration database of the Dutch government, as well as communications with both manufacturing companies of production equipment and textile companies. The output of the calculations is presented in four single indicators: Eco-costs 2012 (a prevention-based indicator), CO_2 equivalent (carbon footprint), cumulative energy demand (CED), and ReCiPe (a damage-based indicator). Results and discussion From an analysis of the data, it becomes clear that the environmental burden is not only a function of the base materials (cotton, PET, nylon, acryl, and elastane) but also of the thickness of the yarn (for this research, the range of 50–500 dtex is examined). The authors propose that the environmental burden of spinning, weaving, and knitting is a function of 1/yarn size. The cradle-to-grave analysis from raw material extraction to discarded textile demonstrates that textiles made out of acryl and PET have the least impact on the environment, followed by elastane, nylon, and cotton. The use phase has less relative impact than it is suggested in the classical literature. Conclusions The impact of spinning and weaving is relatively high (for yarn thicknesses of less than 100 dtex), and from the environmental point of view, knitting is better than weaving. LCA on textiles can only be accurate when the yarn thickness is specified. In case the functional unit also indicates the fabric per square meter, the density must be known. LCA results of textile products over the whole value chain are case dependent, especially when dyeing and finishing processes and the use phase and end-of-life are included in the analysis. Further LCI data studies on textiles and garments are urgently needed to lower the uncertainties in contemporary LCA of textile materials and products.

  • LCA Benchmarking Study on textiles made of cotton, polyester, nylon, acryl, or elastane
    The International Journal of Life Cycle Assessment, 2013
    Co-Authors: Natascha M. Van Der Velden, Martin Kumar Patel, J.g. Vogtländer
    Abstract:

    The purpose of this paper is to provide an improved (up-to-date) insight into the environmental burden of textiles made of the base materials cotton, polyester (PET), nylon, acryl, and elastane. The research question is: Which base material and which life cycle stage (cradle-to-gate as well as cradle-to-grave) have the biggest impact on the environment? Life cycle inventory (LCI) data are collected from the literature, life cycle assessment (LCA) databases, and emission registration database of the Dutch government, as well as communications with both manufacturing companies of production equipment and textile companies. The output of the calculations is presented in four single indicators: Eco-costs 2012 (a prevention-based indicator), CO2 equivalent (carbon footprint), cumulative energy demand (CED), and ReCiPe (a damage-based indicator). From an analysis of the data, it becomes clear that the environmental burden is not only a function of the base materials (cotton, PET, nylon, acryl, and elastane) but also of the thickness of the yarn (for this research, the range of 50–500 dtex is examined). The authors propose that the environmental burden of spinning, weaving, and knitting is a function of 1/yarn size. The cradle-to-grave analysis from raw material extraction to discarded textile demonstrates that textiles made out of acryl and PET have the least impact on the environment, followed by elastane, nylon, and cotton. The use phase has less relative impact than it is suggested in the classical literature. The impact of spinning and weaving is relatively high (for yarn thicknesses of less than 100 dtex), and from the environmental point of view, knitting is better than weaving. LCA on textiles can only be accurate when the yarn thickness is specified. In case the functional unit also indicates the fabric per square meter, the density must be known. LCA results of textile products over the whole value chain are case dependent, especially when dyeing and finishing processes and the use phase and end-of-life are included in the analysis. Further LCI data studies on textiles and garments are urgently needed to lower the uncertainties in contemporary LCA of textile materials and products.

Jorge R Krokstad - One of the best experts on this subject based on the ideXlab platform.

  • numerical Benchmarking Study of a selection of wave energy converters
    Renewable Energy, 2012
    Co-Authors: Aurelie Abari, Jorge Hals, Made Jaya Muliawa, Adi Kurniawa, Torgei Moa, Jorge R Krokstad
    Abstract:

    The aim of this Study is to estimate the mean annual power absorption of a selection of eight Wave Energy Converters (WECs) with different working principles. Based on these estimates a set of power performance measures that can be related to costs are derived. These are the absorbed energy per characteristic mass [kWh/kg], per characteristic surface area [MWh/m2], and per root mean square of Power Take Off (PTO) force [kWh/N].

  • numerical Benchmarking Study of a selection of wave energy converters
    Renewable Energy, 2012
    Co-Authors: Aurelien Babarit, Jorge Hals, Made Jaya Muliawan, Adi Kurniawan, Torgeir Moan, Jorge R Krokstad
    Abstract:

    Abstract The aim of this Study is to estimate the mean annual power absorption of a selection of eight Wave Energy Converters (WECs) with different working principles. Based on these estimates a set of power performance measures that can be related to costs are derived. These are the absorbed energy per characteristic mass [kWh/kg], per characteristic surface area [MWh/m2], and per root mean square of Power Take Off (PTO) force [kWh/N]. The methodology relies on numerical modelling. For each device, a numerical Wave-to-Wire (W2W) model is built based on the equations of motion. Physical effects are modelled according to the state-of-the-art within hydrodynamic modelling practise. Then, the W2W models are used to calculate the power matrices of each device and the mean annual power absorption at five different representative wave sites along the European Coast, at which the mean level of wave power resource ranges between 15 and 88 kW per metre of wave front. Uncertainties are discussed and estimated for each device. Computed power matrices and results for the mean annual power absorption are assembled in a summary sheet per device. Comparisons of the selected devices show that, despite very different working principles and dimensions, power performance measures vary much less than the mean annual power absorption. With the chosen units, these measures are all shown to be of the order of 1.

Martin Kumar Patel - One of the best experts on this subject based on the ideXlab platform.

  • LCA Benchmarking Study on textiles made of cotton, polyester, nylon, acryl, or elastane
    The International Journal of Life Cycle Assessment, 2014
    Co-Authors: Natascha M. Velden, Martin Kumar Patel, J.g. Vogtländer
    Abstract:

    Purpose The purpose of this paper is to provide an improved (up-to-date) insight into the environmental burden of textiles made of the base materials cotton, polyester (PET), nylon, acryl, and elastane. The research question is: Which base material and which life cycle stage (cradle-to-gate as well as cradle-to-grave) have the biggest impact on the environment? Methods Life cycle inventory (LCI) data are collected from the literature, life cycle assessment (LCA) databases, and emission registration database of the Dutch government, as well as communications with both manufacturing companies of production equipment and textile companies. The output of the calculations is presented in four single indicators: Eco-costs 2012 (a prevention-based indicator), CO_2 equivalent (carbon footprint), cumulative energy demand (CED), and ReCiPe (a damage-based indicator). Results and discussion From an analysis of the data, it becomes clear that the environmental burden is not only a function of the base materials (cotton, PET, nylon, acryl, and elastane) but also of the thickness of the yarn (for this research, the range of 50–500 dtex is examined). The authors propose that the environmental burden of spinning, weaving, and knitting is a function of 1/yarn size. The cradle-to-grave analysis from raw material extraction to discarded textile demonstrates that textiles made out of acryl and PET have the least impact on the environment, followed by elastane, nylon, and cotton. The use phase has less relative impact than it is suggested in the classical literature. Conclusions The impact of spinning and weaving is relatively high (for yarn thicknesses of less than 100 dtex), and from the environmental point of view, knitting is better than weaving. LCA on textiles can only be accurate when the yarn thickness is specified. In case the functional unit also indicates the fabric per square meter, the density must be known. LCA results of textile products over the whole value chain are case dependent, especially when dyeing and finishing processes and the use phase and end-of-life are included in the analysis. Further LCI data studies on textiles and garments are urgently needed to lower the uncertainties in contemporary LCA of textile materials and products.

  • LCA Benchmarking Study on textiles made of cotton, polyester, nylon, acryl, or elastane
    The International Journal of Life Cycle Assessment, 2013
    Co-Authors: Natascha M. Van Der Velden, Martin Kumar Patel, J.g. Vogtländer
    Abstract:

    The purpose of this paper is to provide an improved (up-to-date) insight into the environmental burden of textiles made of the base materials cotton, polyester (PET), nylon, acryl, and elastane. The research question is: Which base material and which life cycle stage (cradle-to-gate as well as cradle-to-grave) have the biggest impact on the environment? Life cycle inventory (LCI) data are collected from the literature, life cycle assessment (LCA) databases, and emission registration database of the Dutch government, as well as communications with both manufacturing companies of production equipment and textile companies. The output of the calculations is presented in four single indicators: Eco-costs 2012 (a prevention-based indicator), CO2 equivalent (carbon footprint), cumulative energy demand (CED), and ReCiPe (a damage-based indicator). From an analysis of the data, it becomes clear that the environmental burden is not only a function of the base materials (cotton, PET, nylon, acryl, and elastane) but also of the thickness of the yarn (for this research, the range of 50–500 dtex is examined). The authors propose that the environmental burden of spinning, weaving, and knitting is a function of 1/yarn size. The cradle-to-grave analysis from raw material extraction to discarded textile demonstrates that textiles made out of acryl and PET have the least impact on the environment, followed by elastane, nylon, and cotton. The use phase has less relative impact than it is suggested in the classical literature. The impact of spinning and weaving is relatively high (for yarn thicknesses of less than 100 dtex), and from the environmental point of view, knitting is better than weaving. LCA on textiles can only be accurate when the yarn thickness is specified. In case the functional unit also indicates the fabric per square meter, the density must be known. LCA results of textile products over the whole value chain are case dependent, especially when dyeing and finishing processes and the use phase and end-of-life are included in the analysis. Further LCI data studies on textiles and garments are urgently needed to lower the uncertainties in contemporary LCA of textile materials and products.

Hao Fan - One of the best experts on this subject based on the ideXlab platform.

  • A Benchmarking Study on virtual ligand screening against homology models of human GPCRs
    Proteins: Structure Function and Bioinformatics, 2018
    Co-Authors: Victor Jun Yu Lim, Yu Zong Chen, Hao Fan
    Abstract:

    G-protein-coupled receptor (GPCR) is an important target class of proteins for drug discovery, with over 27% of FDA-approved drugs targeting GPCRs. However, being a membrane protein, it is difficult to obtain the 3D crystal structures of GPCRs for virtual screening of ligands by molecular docking. Thus, we evaluated the virtual screening performance of homology models of human GPCRs with respect to the corresponding crystal structures. Among the 19 GPCRs involved in this Study, we observed that 10 GPCRs have homology models that have better or comparable performance with respect to the corresponding X-ray structures, making homology models a viable choice for virtual screening. For a small subset of GPCRs, we also explored how certain methods like consensus enrichment and sidechain perturbation affect the utility of homology models in virtual screening, as well as the selectivity between agonists and antagonists. Most notably, consensus enrichment across multiple homology models often yields results comparable to the best performing model, suggesting that ligand candidates predicted with consensus scores from multiple models can be the optimal option in practical applications where the performance of each model cannot be estimated.

  • A Benchmarking Study on virtual ligand screening against homology models of human GPCRs
    2018
    Co-Authors: Victor Jun Yu Lim, Yu Zong Chen, Hao Fan
    Abstract:

    G-protein-coupled receptor (GPCR) is an important target class of proteins for drug discovery, with over 27% of FDA-approved drugs targeting GPCRs. However, being a membrane protein, it is difficult to obtain the 3D crystal structures of GPCRs for virtual screening of ligands by molecular docking. Thus, we evaluated the virtual screening performance of homology models of human GPCRs with respect to the corresponding crystal structures. Among the 19 GPCRs involved in this Study, we observed that 10 GPCRs have homology models that have better or comparable performance with respect to the corresponding X-ray structures, making homology models a viable choice for virtual screening. For a small subset of GPCRs, we also explored how certain methods like consensus enrichment and sidechain perturbation affect the utility of homology models in virtual screening, as well as the selectivity between agonists and antagonists. Most notably, consensus enrichment across multiple homology models often yields results comparable to the best performing model, suggesting that ligand candidates predicted with consensus scores from multiple models can be the optimal option in practical applications where X-ray structure is not available and the performance of each model cannot be estimated.

Jorge Hals - One of the best experts on this subject based on the ideXlab platform.

  • numerical Benchmarking Study of a selection of wave energy converters
    Renewable Energy, 2012
    Co-Authors: Aurelie Abari, Jorge Hals, Made Jaya Muliawa, Adi Kurniawa, Torgei Moa, Jorge R Krokstad
    Abstract:

    The aim of this Study is to estimate the mean annual power absorption of a selection of eight Wave Energy Converters (WECs) with different working principles. Based on these estimates a set of power performance measures that can be related to costs are derived. These are the absorbed energy per characteristic mass [kWh/kg], per characteristic surface area [MWh/m2], and per root mean square of Power Take Off (PTO) force [kWh/N].

  • numerical Benchmarking Study of a selection of wave energy converters
    Renewable Energy, 2012
    Co-Authors: Aurelien Babarit, Jorge Hals, Made Jaya Muliawan, Adi Kurniawan, Torgeir Moan, Jorge R Krokstad
    Abstract:

    Abstract The aim of this Study is to estimate the mean annual power absorption of a selection of eight Wave Energy Converters (WECs) with different working principles. Based on these estimates a set of power performance measures that can be related to costs are derived. These are the absorbed energy per characteristic mass [kWh/kg], per characteristic surface area [MWh/m2], and per root mean square of Power Take Off (PTO) force [kWh/N]. The methodology relies on numerical modelling. For each device, a numerical Wave-to-Wire (W2W) model is built based on the equations of motion. Physical effects are modelled according to the state-of-the-art within hydrodynamic modelling practise. Then, the W2W models are used to calculate the power matrices of each device and the mean annual power absorption at five different representative wave sites along the European Coast, at which the mean level of wave power resource ranges between 15 and 88 kW per metre of wave front. Uncertainties are discussed and estimated for each device. Computed power matrices and results for the mean annual power absorption are assembled in a summary sheet per device. Comparisons of the selected devices show that, despite very different working principles and dimensions, power performance measures vary much less than the mean annual power absorption. With the chosen units, these measures are all shown to be of the order of 1.