The Experts below are selected from a list of 1617 Experts worldwide ranked by ideXlab platform
Liyang Zhang - One of the best experts on this subject based on the ideXlab platform.
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exosomal hsa mir 21 5p derived from growth hormone secreting pituitary adenoma promotes abnormal bone formation in acromegaly
Translational Research, 2020Co-Authors: Yuanyuan Xiong, Yongjian Tang, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang ZhangAbstract:Growth hormone-secreting pituitary adenoma (GHPA), a Benign Endocrine Tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the Tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.
Yuanyuan Xiong - One of the best experts on this subject based on the ideXlab platform.
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exosomal hsa mir 21 5p derived from growth hormone secreting pituitary adenoma promotes abnormal bone formation in acromegaly
Translational Research, 2020Co-Authors: Yuanyuan Xiong, Yongjian Tang, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang ZhangAbstract:Growth hormone-secreting pituitary adenoma (GHPA), a Benign Endocrine Tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the Tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.
Yongjian Tang - One of the best experts on this subject based on the ideXlab platform.
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exosomal hsa mir 21 5p derived from growth hormone secreting pituitary adenoma promotes abnormal bone formation in acromegaly
Translational Research, 2020Co-Authors: Yuanyuan Xiong, Yongjian Tang, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang ZhangAbstract:Growth hormone-secreting pituitary adenoma (GHPA), a Benign Endocrine Tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the Tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.
Yu Zeng - One of the best experts on this subject based on the ideXlab platform.
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exosomal hsa mir 21 5p derived from growth hormone secreting pituitary adenoma promotes abnormal bone formation in acromegaly
Translational Research, 2020Co-Authors: Yuanyuan Xiong, Yongjian Tang, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang ZhangAbstract:Growth hormone-secreting pituitary adenoma (GHPA), a Benign Endocrine Tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the Tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.
Chuntao Li - One of the best experts on this subject based on the ideXlab platform.
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exosomal hsa mir 21 5p derived from growth hormone secreting pituitary adenoma promotes abnormal bone formation in acromegaly
Translational Research, 2020Co-Authors: Yuanyuan Xiong, Yongjian Tang, Yu Zeng, Chuntao Li, Gaofeng Zhou, Zhongliang Hu, Liyang ZhangAbstract:Growth hormone-secreting pituitary adenoma (GHPA), a Benign Endocrine Tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the Tumor itself in the sellar region, GHPA can lead to the overgrowth of almost every organ. Previous findings indicated that the processes underlying acromegaly were partly attributable to hyperactivity of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. However, the mechanisms driving this syndrome remains largely unknown. Additionally, the roles of GHPA-derived exosomes, which contain functional microRNAs and proteins that manipulate target cell proliferation and differentiation in distal extremities, are also unknown. In this study, we demonstrated that GHPA exosomes promote bone formation in vitro and trabecula number in vivo. The mechanism of increased trabecula formation may be attributable to GHPA exosome-induced osteoblast proliferation via increased cell viability and DNA replication. We further discovered that exosomal hsa-miR-21-5p plays a distinct role from the GH/IGF-1 axis in these processes. Accordingly, the results of this study provide a novel mechanism whereby GHPA influences distal extremities and a new perspective for treating GHPA.