The Experts below are selected from a list of 26232 Experts worldwide ranked by ideXlab platform
Gerald B Hammond - One of the best experts on this subject based on the ideXlab platform.
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gold catalyzed annulations of 2 alkynyl Benzaldehydes with vinyl ethers synthesis of dihydronaphthalene isochromene and bicyclo 2 2 2 octane derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
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Gold‐Catalyzed Annulations of 2‐Alkynyl Benzaldehydes with Vinyl Ethers: Synthesis of Dihydronaphthalene, Isochromene, and Bicyclo[2.2.2]octane Derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
Deepika Malhotra - One of the best experts on this subject based on the ideXlab platform.
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gold catalyzed annulations of 2 alkynyl Benzaldehydes with vinyl ethers synthesis of dihydronaphthalene isochromene and bicyclo 2 2 2 octane derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
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Gold‐Catalyzed Annulations of 2‐Alkynyl Benzaldehydes with Vinyl Ethers: Synthesis of Dihydronaphthalene, Isochromene, and Bicyclo[2.2.2]octane Derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
Mark S Mashuta - One of the best experts on this subject based on the ideXlab platform.
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gold catalyzed annulations of 2 alkynyl Benzaldehydes with vinyl ethers synthesis of dihydronaphthalene isochromene and bicyclo 2 2 2 octane derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
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Gold‐Catalyzed Annulations of 2‐Alkynyl Benzaldehydes with Vinyl Ethers: Synthesis of Dihydronaphthalene, Isochromene, and Bicyclo[2.2.2]octane Derivatives
Chemistry: A European Journal, 2013Co-Authors: Deepika Malhotra, Mark S Mashuta, Gerald B HammondAbstract:: With the suitable selection of a gold catalyst as well as the appropriate control of the reaction conditions, various new gold-catalyzed cyclizations of 2-alkynyl Benzaldehyde with acyclic or cyclic vinyl ethers have been developed. Acetal-tethered dihydronaphthalene and isochromenes were obtained from the reactions of 2-alkynyl Benzaldehydes with acyclic vinyl ethers under mild conditions. And, more interestingly, the gold-catalyzed reactions of 2-alkynyl Benzaldehyde with a cyclic vinyl ether afforded the bicyclo[2.2.2]octane derivative involving two molecules of cyclic vinyl ethers. These products contain interesting substructures that have been found in many biologically active molecules and natural products. In addition, a gold-catalyzed homo-dimerization of 2-phenylethynyl Benzaldehyde 1a was observed when the reaction was carried out in the absence of vinyl ether, affording a set of separable diastereomeric products. Plausible mechanisms for these transformations are discussed; a gold-containing benzopyrylium was regarded as the crucial intermediate by which a number of these new transformations took place.
Neil R. Brooks - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective Stobbe condensation of ethyl methyl diphenylmethylenesuccinate with aromatic aldehydes.
Organic letters, 2002Co-Authors: Jin Liu, Neil R. BrooksAbstract:The E configuration of benzylidene(diphenylmethylene)succinic anhydride (R = H), obtained by the Stobbe condensation of ethyl methyl diphenylmethylenesuccinate with Benzaldehyde, was determined by single-crystal X-ray diffraction. Noncovalent π stacking interaction between two stacked phenyl groups is suggested as a stabilizing energy for the highly crowded molecule. The nature and the position of substituents (R) on the aromatic rings of substituted Benzaldehydes showed no effect on the E stereoselectivity in the condensation.
Patrick Gamez - One of the best experts on this subject based on the ideXlab platform.
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Thiosemicarbazone Derivatives as Inhibitors of Amyloid-β Aggregation: Effect of Metal Coordination.
Inorganic Chemistry, 2020Co-Authors: Ana I. Matesanz, Ana B. Caballero, Carmen Lorenzo, Alba Espargaró, Raimon Sabaté, Adoración G. Quiroga, Patrick GamezAbstract:Three thiosemicarbazone derivatives, namely 4-(dimethylamino)Benzaldehyde 4,4-dimethylthiosemicarbazone (HL1), 4-(dimethylamino)Benzaldehyde thiosemicarbazone (HL2), and 4-(dimethylamino)benzaldehy...
