The Experts below are selected from a list of 6357 Experts worldwide ranked by ideXlab platform
Lidija Colombo - One of the best experts on this subject based on the ideXlab platform.
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Normal coordinate analysis of the vibrational spectrum of Benzil molecule
Journal of Molecular Structure, 1993Co-Authors: Vesna Volovšek, Lidija ColomboAbstract:Abstract Normal coordinate analysis is performed for the Benzil molecule. Force constants of phenyl rings are transferred from earlier studies on binuclear aromatic molecules. The existance of some low-frequency internal modes have been proved, thus eliminating the earlier explanations of the excess of the bands observed in the low-frequency Raman and FIR spectra of Benzil crystal.
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normal coordinate analysis of the vibrational transitions in Benzil
The Journal of Physical Chemistry, 1993Co-Authors: Vesna Volovšek, Lidija ColomboAbstract:Normal coordinate analysis is performed for the Benzil molecule. Force constants of phenyl rings are transferred from earlier studies on binuclear aromatic molecules. The existence of some low-frequency internal modes has been proved, thus eliminating the earlier explanations of the excess of the bands observed in the low-frequency Raman and FIR spectra of the Benzil crystal
Vesna Volovšek - One of the best experts on this subject based on the ideXlab platform.
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Normal coordinate analysis of the vibrational spectrum of Benzil molecule
Journal of Molecular Structure, 1993Co-Authors: Vesna Volovšek, Lidija ColomboAbstract:Abstract Normal coordinate analysis is performed for the Benzil molecule. Force constants of phenyl rings are transferred from earlier studies on binuclear aromatic molecules. The existance of some low-frequency internal modes have been proved, thus eliminating the earlier explanations of the excess of the bands observed in the low-frequency Raman and FIR spectra of Benzil crystal.
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normal coordinate analysis of the vibrational transitions in Benzil
The Journal of Physical Chemistry, 1993Co-Authors: Vesna Volovšek, Lidija ColomboAbstract:Normal coordinate analysis is performed for the Benzil molecule. Force constants of phenyl rings are transferred from earlier studies on binuclear aromatic molecules. The existence of some low-frequency internal modes has been proved, thus eliminating the earlier explanations of the excess of the bands observed in the low-frequency Raman and FIR spectra of the Benzil crystal
Juliana Moreira - One of the best experts on this subject based on the ideXlab platform.
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a diffuse reflectance comparative study of Benzil inclusion within p tert butylcalix n arenes n 4 6 and 8 and silicalite
Journal of Physical Chemistry B, 2002Co-Authors: L Vieira F Ferreira, José P. Da Silva, Anabela Sousa Oliveira, Ferreira I Machado, M Vieira R Ferreira, Juliana MoreiraAbstract:Diffuse reflectance and laser-induced techniques were used to access photochemical and photophysical processes of Benzil in solid supports, namely p-tert-butylcalix[n]arenes with n = 4, 6, and 8. A comparative study was performed using these results and those obtained with another electronically inert support, silicalite, which is a hydrophobic zeolite. In the latter substrate, ground-state Benzil has the two carbonyl groups in an s-trans planar conformation while in the calixarenes a distribution of conformers exists, largely dominated by skew conformations where the carbonyl groups are twisted one to the other. In all substrates, room-temperature phosphorescence was obtained in air-equilibrated samples. The decay times vary greatly and the largest lifetime was obtained for Benzil/p-tert-butylcalix[6]arene, showing that this host cavity well accommodates Benzil, enhancing its room-temperature phosphorescence. p-tert-Butylcalix[6] and [8]arene molecules provide larger hydrophobic cavities than silicalite,...
Mouad Alami - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and antitumor activity of Benzils related to combretastatin A-4
Bioorganic & Medicinal Chemistry Letters, 2008Co-Authors: Celine Mousset, Anne Giraud, Olivier Provot, Abdallah Hamze, Jérôme Bignon, Jian-miao Liu, Sylviane Thoret, Joëlle Dubois, Jean-daniel Brion, Mouad AlamiAbstract:Abstract A series of Benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by oxidation of diarylalkynes promoted by PdI 2 in DMSO. Using this new protocol, 14 Benzils were prepared in good to excellent yields and their biological activity has been delineated. Several Benzils exhibited excellent antiproliferative activity: for example, 4j and 4k bearing the greatest resemblance to CA-4 and AVE-8062, respectively, were found to inhibit cell growth at the nanomolar level (20–50 nM) on four human tumor cell lines. Flow cytometric analysis indicates that these compounds act as antimitotics and arrest the cell cycle in G 2 /M phase. A cell-based assay indicated that compounds 4j and 4k displayed a similar inhibition of tubulin assembly with an IC 50 value similar to CA-4. These results clearly demonstrated that the Z -double bond of CA-4 can be replaced by a 1,2-diketone unit without significant loss of cytotoxicity and inhibition of tubulin assembly potency.
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Synthesis and antitumor activity of Benzils related to combretastatin A-4
Bioorganic and Medicinal Chemistry Letters, 2008Co-Authors: Celine Mousset, Anne Giraud, Olivier Provot, Abdallah Hamze, Jérôme Bignon, Jian-miao Liu, Sylviane Thoret, Joëlle Dubois, Jean-daniel Brion, Mouad AlamiAbstract:A series of Benzil derivatives related to combretastatin A-4 (CA-4) has been synthesized by oxidation of diarylalkynes promoted by PdI2 in DMSO. Using this new protocol, 14 Benzils were prepared in good to excellent yields and their biological activity has been delineated. Several Benzils exhibited excellent antiproliferative activity: for example, 4j and 4k bearing the greatest resemblance to CA-4 and AVE-8062 respectively were found to inhibit cell growth at the nanomolar level (20-50 nM) on four human tumor cell lines. Flow cytometric analysis indicates that these compounds act as antimitotics and arrest the cell cycle in G2/M phase. A cell-based assay indicated that compounds 4j and 4k displayed a similar inhibition of tubulin assembly with an IC50 value similar to CA-4. These results clearly demonstrated that the Z-double bond of CA-4 can be replaced by a 1,2-diketone unit without significant loss of cytotoxicity and inhibition of tubulin assembly potency.
Didier M Lambert - One of the best experts on this subject based on the ideXlab platform.
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versatile access to benzhydryl phenylureas through an unexpected rearrangement during microwave enhanced synthesis of hydantoins
Organic Letters, 2003Co-Authors: Giulio G Muccioli, Johan Wouters, Jacques Poupaert, Bernadette Norberg, Wolfgang Poppitz, Gerhard K E Scriba, Didier M LambertAbstract:[reaction: see text] A new access to benzhydryl-phenylureas is described. These new interesting urea derivatives were obtained by reaction of substituted Benzils with substituted phenylureas under microwave irradiation. Phenylthiourea, when reacted with Benzil, gave 3-phenyl-thiohydantoin. Moreover, benzylurea, as phenethylurea, gave the corresponding 3-substituted hydantoin derivatives, demonstrating that only phenylurea derivatives can result in benzhydryl-phenylureas under the applied conditions. This new reaction proved to be an easy access to substituted 1-benzhydryl-3-phenyl-ureas.
