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Benzoapyrene

The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform

Paolo Simioni – 1st expert on this subject based on the ideXlab platform

  • Short-term exposure to high levels of air pollution (nickel) and the risk of acute unprovoked proximal deep vein thrombosis in the legs.
    Internal and Emergency Medicine, 2015
    Co-Authors: Luca Spiezia, Elena Campello, Sara Maggiolo, Daniela Tormene, Paolo Simioni

    Abstract:

    We read with great interest the narrative review recently published by Mannucci et al. [1] in Intern Emerg Med journal dealing with the adverse effects on health of air pollution exposure. As clearly stated by the authors, studies published so far in literature report data mainly on particulate matter (PM), ozone, nitrogen dioxide (NO2), benzene, carbon monoxide (CO) and sulphur dioxide (SO2), but air pollution is ‘‘a mixture of thousands of components’’. In an attempt to overcome this limitation, we recently published data on the association between short-term exposure to elevated levels of air pollution, and the risk of developing a provoked or unprovoked isolated pulmonary embolism (PE) taking into account ‘‘traditional’’ and ‘‘novel’’ pollutants [2]. In this retrospective case–control study, we identified short-term (i.e. 1 month) exposure to elevated levels of PM10 and Benzoapyrene as possible risk factors for the development of acute isolated unprovoked PE. Based on these results, we performed a retrospective case– control study to evaluate the association, if any, between the short-term (i.e. 1 month and one trimester) exposure to elevate levels of air pollution, and the risk of developing an acute idiopathic proximal deep vein thrombosis (DVT) in the legs. All eligible patients enrolled were admitted between April 2010 and December 2012 to the thrombosis unit of our department with an onset of acute symptoms (B2 days) indicative of DVT in the legs, and with a Doppler ultrasound confirmed the diagnosis of proximal DVT. Participants were asked to report the presence of any transient risk factors for DVT in the month prior to the hospital (i.e. trauma, immobilization or surgery, hormonal treatment, pregnancy or puerperium, medical diseases, active cancer). Cases considered were those individuals with unprovoked (without any detectable predisposing factors for thrombosis) DVT; controls were those patients with a provoked (associated to permanent or transient risk factors) DVT. Patients under anticoagulant treatment at the time of the diagnosis of VTE, or younger than 18 or with a previous episode of PE or DVT, or who were residents outside the city of Padua were excluded. Blood samples for thrombophilia screening (i.e. antithrombin, protein C, protein S deficiencies; lupus-like anticoagulants; factor V Leiden and prothrombin gene mutation) were collected from each participant. The level of exposure for each patient enrolled in the study was assessed as previously reported [2]. In particular, average concentrations data of different pollutants (i.e. PM10, CO, NOx, O3, SO2, Benzene, Benzoapyrene, Nickel, Lead and Arsenic) measured over the month and the trimester preceding the DVT diagnosis from two monitoring sites around the city of Padua were obtained from the Regional Agency for Environmental Protection (Agenzia Regionale per la Protezione Ambientale—ARPA Veneto). During the study period, 233 subjects with a diagnosis of acute proximal DVT in the legs were evaluated. Thirteen patients were excluded: five patients from out of town; four Electronic supplementary material The online version of this article (doi:10.1007/s11739-015-1363-9) contains supplementary material, which is available to authorized users.

  • short term exposure to high levels of air pollution as a risk factor for acute isolated pulmonary embolism
    Thrombosis Research, 2014
    Co-Authors: Luca Spiezia, Elena Campello, Sara Maggiolo, Elena Pelizzaro, Paolo Simioni

    Abstract:

    article i nfo Background: The association between air pollution exposure and occurrence of venous thromboembolism is a matter of debate. This retrospective case-control study investigated the associations between one month’s exposure to elevated levels of different pollutants (i.e. PM10 ,C O, NOx, O3 ,S O2, Benzene, Benzoapyrene, Nickel, Lead Arsenic) and the development of acute isolated pulmonary embolism (PE). Methods: The cases included 33 patients consecutively admitted to Padua Hospital with an objectively proven diagnosisofacuteunprovoked(i.e.withoutpredisposingconditions)isolated(i.e.withoutdeepveinthrombosis) PE.Thecontrolgroupconsistedof72consecutivepatientswithobjectivelyprovenacuteprovoked(i.e.associated to predisposing conditions) isolated PE. Average mean concentrations of pollutants in the month before PE diag- nosis were computed by monitors located at 2 different sites throughout the city of Padua, and were obtained from the Regional Agency for Environmental Protection. Results: Individuals who had PM10, NOx, Benzene, Benzoapyrene, Cadmium, and Lead exposure equal/above the 2nd tertile, measured in controls, showed a significant increase in the risk of unprovoked PE. In case of PM10 and Benzoapyrene this risk was not affected after adjustment for possible confounders. In fact, in the multivariate logistic regression analysis, the OR values were 5.24 (95% CI: 1.52-18.12) for PM10 and 3.95 (95% CI: 1.06- 14.71) for Benzoapyrene exposure in the month before PE diagnosis. Conclusions: Our results, although preliminary, identify short-term (i.e. one month) exposure to elevate levels of air pollutants as a possible risk factor for the development of acute isolated PE. Larger studies are needed to confirm our results.

Luca Spiezia – 2nd expert on this subject based on the ideXlab platform

  • Short-term exposure to high levels of air pollution (nickel) and the risk of acute unprovoked proximal deep vein thrombosis in the legs.
    Internal and Emergency Medicine, 2015
    Co-Authors: Luca Spiezia, Elena Campello, Sara Maggiolo, Daniela Tormene, Paolo Simioni

    Abstract:

    We read with great interest the narrative review recently published by Mannucci et al. [1] in Intern Emerg Med journal dealing with the adverse effects on health of air pollution exposure. As clearly stated by the authors, studies published so far in literature report data mainly on particulate matter (PM), ozone, nitrogen dioxide (NO2), benzene, carbon monoxide (CO) and sulphur dioxide (SO2), but air pollution is ‘‘a mixture of thousands of components’’. In an attempt to overcome this limitation, we recently published data on the association between short-term exposure to elevated levels of air pollution, and the risk of developing a provoked or unprovoked isolated pulmonary embolism (PE) taking into account ‘‘traditional’’ and ‘‘novel’’ pollutants [2]. In this retrospective case–control study, we identified short-term (i.e. 1 month) exposure to elevated levels of PM10 and Benzoapyrene as possible risk factors for the development of acute isolated unprovoked PE. Based on these results, we performed a retrospective case– control study to evaluate the association, if any, between the short-term (i.e. 1 month and one trimester) exposure to elevate levels of air pollution, and the risk of developing an acute idiopathic proximal deep vein thrombosis (DVT) in the legs. All eligible patients enrolled were admitted between April 2010 and December 2012 to the thrombosis unit of our department with an onset of acute symptoms (B2 days) indicative of DVT in the legs, and with a Doppler ultrasound confirmed the diagnosis of proximal DVT. Participants were asked to report the presence of any transient risk factors for DVT in the month prior to the hospital (i.e. trauma, immobilization or surgery, hormonal treatment, pregnancy or puerperium, medical diseases, active cancer). Cases considered were those individuals with unprovoked (without any detectable predisposing factors for thrombosis) DVT; controls were those patients with a provoked (associated to permanent or transient risk factors) DVT. Patients under anticoagulant treatment at the time of the diagnosis of VTE, or younger than 18 or with a previous episode of PE or DVT, or who were residents outside the city of Padua were excluded. Blood samples for thrombophilia screening (i.e. antithrombin, protein C, protein S deficiencies; lupus-like anticoagulants; factor V Leiden and prothrombin gene mutation) were collected from each participant. The level of exposure for each patient enrolled in the study was assessed as previously reported [2]. In particular, average concentrations data of different pollutants (i.e. PM10, CO, NOx, O3, SO2, Benzene, Benzoapyrene, Nickel, Lead and Arsenic) measured over the month and the trimester preceding the DVT diagnosis from two monitoring sites around the city of Padua were obtained from the Regional Agency for Environmental Protection (Agenzia Regionale per la Protezione Ambientale—ARPA Veneto). During the study period, 233 subjects with a diagnosis of acute proximal DVT in the legs were evaluated. Thirteen patients were excluded: five patients from out of town; four Electronic supplementary material The online version of this article (doi:10.1007/s11739-015-1363-9) contains supplementary material, which is available to authorized users.

  • short term exposure to high levels of air pollution as a risk factor for acute isolated pulmonary embolism
    Thrombosis Research, 2014
    Co-Authors: Luca Spiezia, Elena Campello, Sara Maggiolo, Elena Pelizzaro, Paolo Simioni

    Abstract:

    article i nfo Background: The association between air pollution exposure and occurrence of venous thromboembolism is a matter of debate. This retrospective case-control study investigated the associations between one month’s exposure to elevated levels of different pollutants (i.e. PM10 ,C O, NOx, O3 ,S O2, Benzene, Benzoapyrene, Nickel, Lead Arsenic) and the development of acute isolated pulmonary embolism (PE). Methods: The cases included 33 patients consecutively admitted to Padua Hospital with an objectively proven diagnosisofacuteunprovoked(i.e.withoutpredisposingconditions)isolated(i.e.withoutdeepveinthrombosis) PE.Thecontrolgroupconsistedof72consecutivepatientswithobjectivelyprovenacuteprovoked(i.e.associated to predisposing conditions) isolated PE. Average mean concentrations of pollutants in the month before PE diag- nosis were computed by monitors located at 2 different sites throughout the city of Padua, and were obtained from the Regional Agency for Environmental Protection. Results: Individuals who had PM10, NOx, Benzene, Benzoapyrene, Cadmium, and Lead exposure equal/above the 2nd tertile, measured in controls, showed a significant increase in the risk of unprovoked PE. In case of PM10 and Benzoapyrene this risk was not affected after adjustment for possible confounders. In fact, in the multivariate logistic regression analysis, the OR values were 5.24 (95% CI: 1.52-18.12) for PM10 and 3.95 (95% CI: 1.06- 14.71) for Benzoapyrene exposure in the month before PE diagnosis. Conclusions: Our results, although preliminary, identify short-term (i.e. one month) exposure to elevate levels of air pollutants as a possible risk factor for the development of acute isolated PE. Larger studies are needed to confirm our results.

Long We – 3rd expert on this subject based on the ideXlab platform

  • structures and properties of Benzoapyrene by quantum chemistry method
    Journal of Tianjin Normal University, 2013
    Co-Authors: Long We

    Abstract:

    The molecular structure and electronic structures of benzopyrene were studied by the four quantum chemistry methods of HF,B3LYP,B3PW91 and MP2 on 6-311++G(d,p)basis set. By analysis of the geometric structure,Wiberg bond order,spectrum and atomic charge population,which was consistent with the frontier molecular orbital theory knowledge,the stability and the reactivity of Benzoapyrene were explored. The results showed that Benzoapyrene molecular was annular planar type,where the activity of the carbon atoms was different,and the reactivity of the C(8) was the highest and most easily accepted electrophilic reagent. Frontier orbital analysis showed that benzaopyrene molecule mainly accepted electrons. ΔEL-H= 3.048 eV showed that the molecule had a suitable energy band width, which can be used as a raw material of the organic light emitting material. Some different methods were used to research the thermodynamic properties of benzopyrene, and some thermodynamics property parameters at different temperatures were found.Furthermore,MP2 method showed more accurate advantage in energy calculation.