The Experts below are selected from a list of 29796 Experts worldwide ranked by ideXlab platform
Yan Xiong - One of the best experts on this subject based on the ideXlab platform.
-
metal free direct n Benzylation of sulfonamides with Benzyl Alcohols by employing boron trifluoride diethyl ether complex
Synthesis, 2015Co-Authors: Jiaqiang Li, Ruofeng Huang, Xiaohui Zhang, Hang Shen, Yan XiongAbstract:N-Benzylation of sulfonamides with both primary and secondary Benzyl Alcohols by employing boron trifluoride–diethyl ether complex under mild reaction conditions has been developed, which is an environmentally benign and facile protocol for assembling a series of primary and secondary Benzyl sulfonamides in yields up to 83%. In this coupling reaction, the beneficial role of water has been clarified in detail through control experiments.
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
ChemInform, 2015Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Jiaqiang Li, Chao He, Xiaohui Zhang, Yan XiongAbstract:The in situ prepared BF3—H2O reagent promotes the presented Benzylation to give the products in moderate to excellent yields with good regioselectivities for secondary Benzyl Alcohols (VII).
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
RSC Advances, 2014Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Yan Xiong, Xiaohui Zhang, Jing PanAbstract:A convenient procedure employing simple starting materials Benzyl Alcohols and acetates as the Benzyl donors to assemble a series of diarylalkanes through Benzylation of arenes using in situ prepared superacid BF3–H2O as an efficient promoter has been developed. The beneficial role of water in the reaction has been clarified with combination of control experiments and 11B NMR analysis. This reaction is a self-promoted model, which is triggered by the trace of water and continuously promoted by self released by-product water (or carboxylic acid). A wide range of substrates are investigated and the moderate to excellent yields and the good regioselectivities for secondary Benzyl Alcohols as well as arenes bearing electron-withdrawing groups have been achieved. As a result, moisture in the reaction system has been utilized as an efficient initiator in all Benzylation cases.
Xiaohui Zhang - One of the best experts on this subject based on the ideXlab platform.
-
metal free direct n Benzylation of sulfonamides with Benzyl Alcohols by employing boron trifluoride diethyl ether complex
Synthesis, 2015Co-Authors: Jiaqiang Li, Ruofeng Huang, Xiaohui Zhang, Hang Shen, Yan XiongAbstract:N-Benzylation of sulfonamides with both primary and secondary Benzyl Alcohols by employing boron trifluoride–diethyl ether complex under mild reaction conditions has been developed, which is an environmentally benign and facile protocol for assembling a series of primary and secondary Benzyl sulfonamides in yields up to 83%. In this coupling reaction, the beneficial role of water has been clarified in detail through control experiments.
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
ChemInform, 2015Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Jiaqiang Li, Chao He, Xiaohui Zhang, Yan XiongAbstract:The in situ prepared BF3—H2O reagent promotes the presented Benzylation to give the products in moderate to excellent yields with good regioselectivities for secondary Benzyl Alcohols (VII).
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
RSC Advances, 2014Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Yan Xiong, Xiaohui Zhang, Jing PanAbstract:A convenient procedure employing simple starting materials Benzyl Alcohols and acetates as the Benzyl donors to assemble a series of diarylalkanes through Benzylation of arenes using in situ prepared superacid BF3–H2O as an efficient promoter has been developed. The beneficial role of water in the reaction has been clarified with combination of control experiments and 11B NMR analysis. This reaction is a self-promoted model, which is triggered by the trace of water and continuously promoted by self released by-product water (or carboxylic acid). A wide range of substrates are investigated and the moderate to excellent yields and the good regioselectivities for secondary Benzyl Alcohols as well as arenes bearing electron-withdrawing groups have been achieved. As a result, moisture in the reaction system has been utilized as an efficient initiator in all Benzylation cases.
Ruofeng Huang - One of the best experts on this subject based on the ideXlab platform.
-
metal free direct n Benzylation of sulfonamides with Benzyl Alcohols by employing boron trifluoride diethyl ether complex
Synthesis, 2015Co-Authors: Jiaqiang Li, Ruofeng Huang, Xiaohui Zhang, Hang Shen, Yan XiongAbstract:N-Benzylation of sulfonamides with both primary and secondary Benzyl Alcohols by employing boron trifluoride–diethyl ether complex under mild reaction conditions has been developed, which is an environmentally benign and facile protocol for assembling a series of primary and secondary Benzyl sulfonamides in yields up to 83%. In this coupling reaction, the beneficial role of water has been clarified in detail through control experiments.
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
ChemInform, 2015Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Jiaqiang Li, Chao He, Xiaohui Zhang, Yan XiongAbstract:The in situ prepared BF3—H2O reagent promotes the presented Benzylation to give the products in moderate to excellent yields with good regioselectivities for secondary Benzyl Alcohols (VII).
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
RSC Advances, 2014Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Yan Xiong, Xiaohui Zhang, Jing PanAbstract:A convenient procedure employing simple starting materials Benzyl Alcohols and acetates as the Benzyl donors to assemble a series of diarylalkanes through Benzylation of arenes using in situ prepared superacid BF3–H2O as an efficient promoter has been developed. The beneficial role of water in the reaction has been clarified with combination of control experiments and 11B NMR analysis. This reaction is a self-promoted model, which is triggered by the trace of water and continuously promoted by self released by-product water (or carboxylic acid). A wide range of substrates are investigated and the moderate to excellent yields and the good regioselectivities for secondary Benzyl Alcohols as well as arenes bearing electron-withdrawing groups have been achieved. As a result, moisture in the reaction system has been utilized as an efficient initiator in all Benzylation cases.
Shuting Zhang - One of the best experts on this subject based on the ideXlab platform.
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
ChemInform, 2015Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Jiaqiang Li, Chao He, Xiaohui Zhang, Yan XiongAbstract:The in situ prepared BF3—H2O reagent promotes the presented Benzylation to give the products in moderate to excellent yields with good regioselectivities for secondary Benzyl Alcohols (VII).
-
superacid bf3 h2o promoted Benzylation of arenes with Benzyl Alcohols and acetates initiated by trace water
RSC Advances, 2014Co-Authors: Shuting Zhang, Ruofeng Huang, Xuege Ling, Yan Xiong, Xiaohui Zhang, Jing PanAbstract:A convenient procedure employing simple starting materials Benzyl Alcohols and acetates as the Benzyl donors to assemble a series of diarylalkanes through Benzylation of arenes using in situ prepared superacid BF3–H2O as an efficient promoter has been developed. The beneficial role of water in the reaction has been clarified with combination of control experiments and 11B NMR analysis. This reaction is a self-promoted model, which is triggered by the trace of water and continuously promoted by self released by-product water (or carboxylic acid). A wide range of substrates are investigated and the moderate to excellent yields and the good regioselectivities for secondary Benzyl Alcohols as well as arenes bearing electron-withdrawing groups have been achieved. As a result, moisture in the reaction system has been utilized as an efficient initiator in all Benzylation cases.
Dong-hui Luo - One of the best experts on this subject based on the ideXlab platform.
-
bismuth iii bromide catalysed substitution of Benzyl Alcohols with arylsulfonylmethyl isocyanides an unexpected access to sulfinates
Advanced Synthesis & Catalysis, 2015Co-Authors: Rui Wang, Jing Gao, Yuan-yuan Wang, Dong-hui LuoAbstract:A bismuth(III) bromide-catalysed direct substitution of Benzyl Alcohols with arylsulfonylmethyl isocyanides affords sulfinates under mild acidic conditions. An unforeseen reversed reactivity was observed in this highly selective formation of sulfinates instead of the formation of the usually favoured sulfones. Cytotoxicity tests (in vitro) indicated that the sulfinates exhibit antibiotic activity against a human leukaemia cell line HL-60, which would widen the structural diversity of this antitumour target and confirm the perspectives of further investigations.
-
Bismuth(III) Bromide‐Catalysed Substitution of Benzyl Alcohols with Arylsulfonylmethyl Isocyanides: An Unexpected Access to Sulfinates
Advanced Synthesis & Catalysis, 2015Co-Authors: Rui Wang, Jing Gao, Yuan-yuan Wang, Dong-hui LuoAbstract:A bismuth(III) bromide-catalysed direct substitution of Benzyl Alcohols with arylsulfonylmethyl isocyanides affords sulfinates under mild acidic conditions. An unforeseen reversed reactivity was observed in this highly selective formation of sulfinates instead of the formation of the usually favoured sulfones. Cytotoxicity tests (in vitro) indicated that the sulfinates exhibit antibiotic activity against a human leukaemia cell line HL-60, which would widen the structural diversity of this antitumour target and confirm the perspectives of further investigations.