The Experts below are selected from a list of 93 Experts worldwide ranked by ideXlab platform

I Willis - One of the best experts on this subject based on the ideXlab platform.

  • One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial.
    Journal of the American Academy of Dermatology, 1997
    Co-Authors: R Savin, Daniel Stewart, Boni E. Elewski, R L De Villez, S Hong, T Jones, N Lowe, A Lucky, B Reyes, I Willis
    Abstract:

    Butenafine hydrochloride, a Benzylamine Derivative with potent antifungal activity, has been used in Japan to treat superficial fungal diseases. We evaluated the safety and efficacy of twice-daily butenafine versus its vehicle in the treatment of interdigital tinea pedis in a multicenter, randomized, double-blind, parallel-group trial. A total of 402 patients with interdigital tinea pedis and a positive potassium hydroxide examination were enrolled. Of the 271 patients who had culture-confirmed tinea pedis and were assessed for efficacy, 132 applied butenafine and 139 applied vehicle twice daily for 1 week. Patients were assessed for mycologic cure, effective treatment, overall cure, and mycologic/clinical cure. The rates of all four end points were significantly higher with butenafine than with vehicle 5 weeks after treatment ended. Rates of mycologic cure and effective treatment with butenafine were significantly higher than with vehicle at cessation of treatment. Adverse events to treatment occurred in less than 1% of patients treated with butenafine and 2% of patients who applied vehicle. Butenafine applied twice daily for 1 week is highly effective in treating interdigital tinea pedis.

  • One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: A multicenter, double-blind trial : Update on Topical therapy for superficial fungal infections : Focus on butenafine
    Journal of The American Academy of Dermatology, 1997
    Co-Authors: Ronald C. Savin, Terry M. Jones, Boni E. Elewski, R L De Villez, S Hong, A Lucky, Nicholas J. Lowe, Blas A. Reyes, Daniel R. Stewart, I Willis
    Abstract:

    Background: Butenafine hydrochloride, a Benzylamine Derivative with potent antifungal activity, has been used in Japan to treat superficial fungal diseases. Objective: We evaluated the safety and efficacy of twice-daily butenafine versus its vehicle in the treatment of interdigital tinea pedis in a multicenter, randomized, double-blind, parallel-group trial. Methods: A total of 402 patients with interdigital tinea pedis and a positive potassium hydroxide examination were enrolled. Of the 271 patients who had culture-confirmed tinea pedis and were assessed for efficacy, 132 applied butenafine and 139 applied vehicle twice daily for I week. Patients were assessed for mycologic cure, effective treatment, overall cure, and mycologic/clinical cure. Results: The rates of all four end points were significantly higher with butenafine than with vehicle 5 weeks after treatment ended. Rates of mycologic cure and effective treatment with butenafine were significantly higher than with vehicle at cessation of treatment. Adverse events to treatment occurred in less than 1% of patients treated with butenafine and 2% of patients who applied vehicle. Conclusion: Butenafine applied twice daily for I week is highly effective in treating interdigital tinea pedis.

  • One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: A multicenter, double-blind trial
    Journal of the American Academy of Dermatology, 1997
    Co-Authors: Ronald C. Savin, Daniel Stewart, Terry M. Jones, Boni E. Elewski, R L De Villez, S Hong, A Lucky, Nicholas J. Lowe, Blas A. Reyes, I Willis
    Abstract:

    Abstract Background: Butenafine hydrochloride, a Benzylamine Derivative with potent antifungal activity, has been used in Japan to treat superficial fungal diseases. Objective: We evaluated the safety and efficacy of twice-daily butenafine versus its vehicle in the treatment of interdigital tinea pedis in a multicenter, randomized, double-blind, parallel-group trial. Methods: A total of 402 patients with interdigital tinea pedis and a positive potassium hydroxide examination were enrolled. Of the 271 patients who had culture-confirmed tinea pedis and were assessed for efficacy, 132 applied butenafine and 139 applied vehicle twice daily for 1 week. Patients were assessed for mycologic cure, effective treatment, overall cure, and mycologic/clinical cure. Results: The rates of all four end points were significantly higher with butenafine than with vehicle 5 weeks after treatment ended. Rates of mycologic cure and effective treatment with butenafine were significantly higher than with vehicle at cessation of treatment. Adverse events to treatment occurred in less than 1% of patients treated with butenafine and 2% of patients who applied vehicle. Conclusion: Butenafine applied twice daily for 1 week is highly effective in treating interdigital tinea pedis. (J Am Acad Dermatol 1997;36:S15-19.)

Philippe Thonart - One of the best experts on this subject based on the ideXlab platform.

  • Amino Acids, Iron, and Growth Rate as Key Factors Influencing Production of the Pseudomonas Putida BTP1 Benzylamine Derivative Involved in Systemic Resistance Induction in Different Plants
    Microbial Ecology, 2008
    Co-Authors: Marc Ongena, Emmanuel Jourdan, Mathias Schafer, H Budzikiewicz, Akram Adam, Philippe Thonart
    Abstract:

    The biological control bacterium Pseudomonas putida BTP1 exerts its protective effect mostly by inducing an enhanced state of resistance in the host plant against pathogen attack [induced systemic resistance (ISR)]. We previously reported that a specific compound derived from Benzylamine may be involved in the elicitation of the ISR phenomenon by this Pseudomonas strain. In this article, we provide further information about the N , N -dimethyl- N -tetradecyl- N -benzylammonium structure of this determinant for ISR and show that the Benzylamine moiety may be important for perception of the molecule by root cells of different plant species. We also investigated some regulatory aspects of elicitor production with the global aim to better understand how in situ expression of these ISR elicitors can be modulated by physiological and environmental factors. The biosynthesis is clearly related to secondary metabolism, and chemostat experiments showed that the molecule is more efficiently produced at low cell growth rate. Interestingly, the presence of free amino acids in the environment is necessary for optimal production, and a specific positive effect of phenylalanine was evidenced in pulsed continuous cultures. The influence of other abiotic factors, such as mineral content, oxygen concentration, or pH, on elicitor production is also reported and discussed with respect to the specific conditions that the producing strain undergoes in the rhizosphere environment.

  • isolation of an n alkylated Benzylamine Derivative from pseudomonas putida btp1 as elicitor of induced systemic resistance in bean
    Molecular Plant-microbe Interactions, 2005
    Co-Authors: Marc Ongena, Emmanuel Jourdan, Mathias Schafer, Cecile Kech, H Budzikiewicz, Andre Luxen, Philippe Thonart
    Abstract:

    Root treatment of Phaseolus vulgaris with the nonpathogenic Pseudomonas putida BTP1 led to significant reduction of the disease caused by the pathogen Botrytis cinerea on leaves. The molecular determinant of P. putida BTP1 mainly responsible for the induced systemic resistance (ISR) was isolated from cell-free culture fluid after growth of the strain in the iron-poor casamino acid medium. Mass spectrometry analyses performed on both the bacterial product and synthetic analogues revealed a polyalkylated Benzylamine structure, with the quaternary ammonium substituted by methyl, ethyl, and C13 aliphatic groups responsible for the relative hydrophobicity of the molecule. The specific involvement of the N-alkylated Benzylamine Derivative (NABD) in ISR elicitation was first evidenced by testing the purified compound that mimicked the protective effect afforded by crude supernatant samples. The evidence was supported by the loss of elicitor activity of mutants impaired in NABD biosynthesis. Our experiments also showed that other iron-regulated metabolites secreted by the strain are not involved in ISR stimulation. Thus, these results indicate a wider variety of Pseudomonas determinants for ISR than reported to date.

Raosahab Kathalupant Kale - One of the best experts on this subject based on the ideXlab platform.

  • synthesis and structure activity relationship of Benzylamine supported platinum iv complexes
    New Journal of Chemistry, 2013
    Co-Authors: Rakesh Kumar Ameta, Man Singh, Raosahab Kathalupant Kale
    Abstract:

    A series of Benzylamine Derivative (BAD) supported platinum(IV) complexes (PtCl4(BADs)2) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure–activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host–guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl4(BADs)2–DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.

  • Synthesis and structure–activity relationship of Benzylamine supported platinum(IV) complexes
    New Journal of Chemistry, 2013
    Co-Authors: Rakesh Kumar Ameta, Man Singh, Raosahab Kathalupant Kale
    Abstract:

    A series of Benzylamine Derivative (BAD) supported platinum(IV) complexes (PtCl4(BADs)2) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure–activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host–guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl4(BADs)2–DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.

Archana Singal - One of the best experts on this subject based on the ideXlab platform.

  • Butenafine and superficial mycoses: current status.
    Expert Opinion on Drug Metabolism & Toxicology, 2008
    Co-Authors: Archana Singal
    Abstract:

    Background: Butenafine hydrochloride, a Benzylamine Derivative, exhibits potent fungicidal activity particularly against dermatophytes, aspergilli, dimorphic and dematiaceous fungi. Objective: To review pharmacokinetics, mechanism of actions and clinical efficacy of butenafine against various dermatophytic and other superficial fungal infections. Methods: Medline search was made using keyword butenafine. All English language articles were considered for this review. For inclusion in clinical efficacy section when ever available randomized controlled trials were considered a priority over other trials. Results/conclusions: The drug has excellent penetration into the epidermis and a prolonged retention time following topical application, conferring residual therapeutic activity after treatment cessation. Butenafine possess anti-inflammatory activity too. Topical butenafine 1% cream has been reported to be efficacious for tinea pedis, tinea corporis and tinea cruris in many randomized clinical trials when us...

  • comparative efficacy of topical 1 butenafine and 1 clotrimazole in tinea cruris and tinea corporis a randomized double blind trial
    Journal of Dermatological Treatment, 2005
    Co-Authors: Archana Singal, Deepika Pandhi, Subhav Kumar Agrawal
    Abstract:

    Localized tinea cruris and tinea corporis can be treated by topical imidazoles (clotrimazole) or newer topical agents like butenafine, a Benzylamine Derivative with fungicidal activity. The therapeutic efficacy of these two agents was compared in this study. Eighty patients, diagnosed clinically to have tinea cruris or localized tinea corporis and confirmed on KOH examination, were randomly assigned to one of the two treatment groups in a double-blind manner; butenafine once daily for 2 weeks or clotrimazole twice daily for 4 weeks. Follow-up was done at 1, 2, 4 and 8 weeks. Clinical assessment score and KOH examination were performed at each visit. Butenafine recipients exhibited higher clinical cure as compared with clotrimazole recipients at the end of 1 week (26.5% vs 2.9%) as well as higher mycological cure (61.7% vs 17.6%). However, this difference was not statistically significant at 4 and 8 weeks of treatment.

Marc Ongena - One of the best experts on this subject based on the ideXlab platform.

  • Amino Acids, Iron, and Growth Rate as Key Factors Influencing Production of the Pseudomonas Putida BTP1 Benzylamine Derivative Involved in Systemic Resistance Induction in Different Plants
    Microbial Ecology, 2008
    Co-Authors: Marc Ongena, Emmanuel Jourdan, Mathias Schafer, H Budzikiewicz, Akram Adam, Philippe Thonart
    Abstract:

    The biological control bacterium Pseudomonas putida BTP1 exerts its protective effect mostly by inducing an enhanced state of resistance in the host plant against pathogen attack [induced systemic resistance (ISR)]. We previously reported that a specific compound derived from Benzylamine may be involved in the elicitation of the ISR phenomenon by this Pseudomonas strain. In this article, we provide further information about the N , N -dimethyl- N -tetradecyl- N -benzylammonium structure of this determinant for ISR and show that the Benzylamine moiety may be important for perception of the molecule by root cells of different plant species. We also investigated some regulatory aspects of elicitor production with the global aim to better understand how in situ expression of these ISR elicitors can be modulated by physiological and environmental factors. The biosynthesis is clearly related to secondary metabolism, and chemostat experiments showed that the molecule is more efficiently produced at low cell growth rate. Interestingly, the presence of free amino acids in the environment is necessary for optimal production, and a specific positive effect of phenylalanine was evidenced in pulsed continuous cultures. The influence of other abiotic factors, such as mineral content, oxygen concentration, or pH, on elicitor production is also reported and discussed with respect to the specific conditions that the producing strain undergoes in the rhizosphere environment.

  • isolation of an n alkylated Benzylamine Derivative from pseudomonas putida btp1 as elicitor of induced systemic resistance in bean
    Molecular Plant-microbe Interactions, 2005
    Co-Authors: Marc Ongena, Emmanuel Jourdan, Mathias Schafer, Cecile Kech, H Budzikiewicz, Andre Luxen, Philippe Thonart
    Abstract:

    Root treatment of Phaseolus vulgaris with the nonpathogenic Pseudomonas putida BTP1 led to significant reduction of the disease caused by the pathogen Botrytis cinerea on leaves. The molecular determinant of P. putida BTP1 mainly responsible for the induced systemic resistance (ISR) was isolated from cell-free culture fluid after growth of the strain in the iron-poor casamino acid medium. Mass spectrometry analyses performed on both the bacterial product and synthetic analogues revealed a polyalkylated Benzylamine structure, with the quaternary ammonium substituted by methyl, ethyl, and C13 aliphatic groups responsible for the relative hydrophobicity of the molecule. The specific involvement of the N-alkylated Benzylamine Derivative (NABD) in ISR elicitation was first evidenced by testing the purified compound that mimicked the protective effect afforded by crude supernatant samples. The evidence was supported by the loss of elicitor activity of mutants impaired in NABD biosynthesis. Our experiments also showed that other iron-regulated metabolites secreted by the strain are not involved in ISR stimulation. Thus, these results indicate a wider variety of Pseudomonas determinants for ISR than reported to date.