The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform

Ki Churl Chang - One of the best experts on this subject based on the ideXlab platform.

  • Effects of GS 386, a novel dihydroisoquinoline compound, on rabbit atrial myocytes and rat aorta
    Drug Development Research, 1994
    Co-Authors: Ki Churl Chang, Choon Ok Park, Seong Geun Hong
    Abstract:

    The effects of GS 386, a novel Benzylisoquinoline Derivative, on Ca2+ current and vasodilatation were investigated using the single rabbit atrial myocyte and rat thoracic aorta preparations. In rabbit myocytes, the Ca2+ current was recorded during various depolarizations for 200 ms from a holding potential of −40 mV using the whole patch-clamp technique. Superfusion of GS 386 led to a reduction of the Ca2+ current amplitude concentration-dependently, in which the IC50 value was 0.25 μM. However, the dependence of the Ca2+ current on the membrane potential was not altered by GS 386. In rat aorta, GS 386 inhibited high K+-induced contractions more strongly than that induced by phenylephrine. These results indicate that GS 386 has Ca2+ antagonistic actions in rat aorta and rabbit heart. © 1994 Wiley-Liss, Inc.

Choon Ok Park - One of the best experts on this subject based on the ideXlab platform.

  • Effects of GS 386, a novel dihydroisoquinoline compound, on rabbit atrial myocytes and rat aorta
    Drug Development Research, 1994
    Co-Authors: Ki Churl Chang, Choon Ok Park, Seong Geun Hong
    Abstract:

    The effects of GS 386, a novel Benzylisoquinoline Derivative, on Ca2+ current and vasodilatation were investigated using the single rabbit atrial myocyte and rat thoracic aorta preparations. In rabbit myocytes, the Ca2+ current was recorded during various depolarizations for 200 ms from a holding potential of −40 mV using the whole patch-clamp technique. Superfusion of GS 386 led to a reduction of the Ca2+ current amplitude concentration-dependently, in which the IC50 value was 0.25 μM. However, the dependence of the Ca2+ current on the membrane potential was not altered by GS 386. In rat aorta, GS 386 inhibited high K+-induced contractions more strongly than that induced by phenylephrine. These results indicate that GS 386 has Ca2+ antagonistic actions in rat aorta and rabbit heart. © 1994 Wiley-Liss, Inc.

Seong Geun Hong - One of the best experts on this subject based on the ideXlab platform.

  • Effects of GS 386, a novel dihydroisoquinoline compound, on rabbit atrial myocytes and rat aorta
    Drug Development Research, 1994
    Co-Authors: Ki Churl Chang, Choon Ok Park, Seong Geun Hong
    Abstract:

    The effects of GS 386, a novel Benzylisoquinoline Derivative, on Ca2+ current and vasodilatation were investigated using the single rabbit atrial myocyte and rat thoracic aorta preparations. In rabbit myocytes, the Ca2+ current was recorded during various depolarizations for 200 ms from a holding potential of −40 mV using the whole patch-clamp technique. Superfusion of GS 386 led to a reduction of the Ca2+ current amplitude concentration-dependently, in which the IC50 value was 0.25 μM. However, the dependence of the Ca2+ current on the membrane potential was not altered by GS 386. In rat aorta, GS 386 inhibited high K+-induced contractions more strongly than that induced by phenylephrine. These results indicate that GS 386 has Ca2+ antagonistic actions in rat aorta and rabbit heart. © 1994 Wiley-Liss, Inc.