The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform

Qy Xing - One of the best experts on this subject based on the ideXlab platform.

  • A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides
    journal of heterocyclic chemistry, 2001
    Co-Authors: Qy Xing, Hz Wang, Zhou X, Jin S, Chan Asc
    Abstract:

    In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected Beta -Lactam Derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.Chemistry, OrganicSCI(E)2ARTICLE3561-5673

  • A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides
    Hetero Corporation, 2001
    Co-Authors: Qy Xing, Hz Wang, Zhou X, Jin S, Chan Asc
    Abstract:

    In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected Beta -Lactam Derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.Department of Applied Biology and Chemical Technolog

  • Synthesis and crystal structure of a Beta-Lactam Derivative of 2,4-diaryl-1,5-benzothiazepine
    结构化学, 1999
    Co-Authors: Li Y, Jin S, Qq Yang, Qy Xing
    Abstract:

    The compound(2) (C24H20NO2CIS) (see Scheme 1) has been synthesized by reaction of 1, 5-benzothiazepine with chloroacetyl chloride and crystallized in the monoclinic system, space group P2(1)/c, alpha = 12. 547(3) , b = 10. 614(2), c = 15. 881 ( 3) Angstrom , Beta = 105. 91(3)degrees, V = 2034. 1(10) Angstrom(3) , D-c = 1. 378 g/cm(3), Z = 4, F(000) = 880, mu(MoK alpha) = 0. 311 mm(-1), R = 0. 0510 and R-omega = 0. 0647 for 1953 observed reflections. Structure analysis reveals that the cycloaddition to Beta-Lactam is stereospecific reaction , the chloro and phenyl substituents in four-membered ring are located on the same side of the nucleus. The conformation of seven-membered ring in compound (2) is chair-like.Chemistry, Inorganic & NuclearCrystallographySCI(E)中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)1ARTICLE157-601

Chan Asc - One of the best experts on this subject based on the ideXlab platform.

Jin S - One of the best experts on this subject based on the ideXlab platform.

  • A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides
    journal of heterocyclic chemistry, 2001
    Co-Authors: Qy Xing, Hz Wang, Zhou X, Jin S, Chan Asc
    Abstract:

    In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected Beta -Lactam Derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.Chemistry, OrganicSCI(E)2ARTICLE3561-5673

  • A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides
    Hetero Corporation, 2001
    Co-Authors: Qy Xing, Hz Wang, Zhou X, Jin S, Chan Asc
    Abstract:

    In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected Beta -Lactam Derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.Department of Applied Biology and Chemical Technolog

  • Synthesis and crystal structure of a Beta-Lactam Derivative of 2,4-diaryl-1,5-benzothiazepine
    结构化学, 1999
    Co-Authors: Li Y, Jin S, Qq Yang, Qy Xing
    Abstract:

    The compound(2) (C24H20NO2CIS) (see Scheme 1) has been synthesized by reaction of 1, 5-benzothiazepine with chloroacetyl chloride and crystallized in the monoclinic system, space group P2(1)/c, alpha = 12. 547(3) , b = 10. 614(2), c = 15. 881 ( 3) Angstrom , Beta = 105. 91(3)degrees, V = 2034. 1(10) Angstrom(3) , D-c = 1. 378 g/cm(3), Z = 4, F(000) = 880, mu(MoK alpha) = 0. 311 mm(-1), R = 0. 0510 and R-omega = 0. 0647 for 1953 observed reflections. Structure analysis reveals that the cycloaddition to Beta-Lactam is stereospecific reaction , the chloro and phenyl substituents in four-membered ring are located on the same side of the nucleus. The conformation of seven-membered ring in compound (2) is chair-like.Chemistry, Inorganic & NuclearCrystallographySCI(E)中文核心期刊要目总览(PKU)中国科学引文数据库(CSCD)1ARTICLE157-601

Hz Wang - One of the best experts on this subject based on the ideXlab platform.

Zhou X - One of the best experts on this subject based on the ideXlab platform.