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E. Rosenthal - One of the best experts on this subject based on the ideXlab platform.

  • Spread ofklebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, E. Eberlein, M. Holley, S. Schweighart, E. Rosenthal
    Abstract:

    Wir berichten über das in Deutschland erstmalig gehäufte Auftreten von Infektionen verursacht durch einen Stamm von Klebsiella pneumoniae , der die plasmidische Betalaktamase SHV-5 produziert. Innerhalb eines Beobachtungszeitraumes von einem Jahr und neun Monaten verursachte dieser Stamm bei 22 Patienten schwere nosokomiale Infektionen zumeist der tiefen Atemwege. Der Erreger war resistent gegenüber Penicillinen, Cephalosporinen der dritten Generation, Aztreonam, Chloramphenicol, Tetrazyklin und Co-trimoxazol. Die Resistenzdeterminanten waren auf Escherichia coli übertragbar. Alle Isolate produzierten eine Betalaktamase mit einem isoelektrischen Punkt von 8,2, die Ceftazidim hydrolysierte. Diese Merkmale zusammen mit dem Resistenz-Phänotyp sind identisch mit denen eines mitgeführten Referenzstammes, der die Betalaktamase SHV-5 produziert. Alle K. pneumoniae -Stämme waren identisch in ihrem Kapsel-Serotyp, ihrem Plasmidmuster und ihrem Plasmid-Fingerprint (nach Verdauen mit der Restriktionsendonuclease Dra I). Wir schließen daraus, daß dieser Ausbruch von Infektionen durch einen einzigen Klon eines Betalaktamase-produzierenden K. pneumoniae -Stammes verursacht wurde, der sich über verschiedene Stationen verbreitete. Diese Ergebnisse signalisieren das Risiko von Therapiemißerfolgen in Deutschland bei empirischem Einsatz von Drittgenerations-Cephalosporinen bei Infektionen mit K. pneumoniae . The first outbreak of infections caused by an SHV-5 producing strain of Klebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistant K. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable to Escherichia coli . All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. The K. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone of K. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

Adolf Bauernfeind - One of the best experts on this subject based on the ideXlab platform.

  • Spread of Klebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients.
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, Rosenthal E, E. Eberlein, M. Holley, S. Schweighart
    Abstract:

    The first outbreak of infections caused by an SHV-5 producing strain ofKlebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistantK. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable toEscherichia coli. All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. TheK. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone ofK. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

  • Spread ofklebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, E. Eberlein, M. Holley, S. Schweighart, E. Rosenthal
    Abstract:

    Wir berichten über das in Deutschland erstmalig gehäufte Auftreten von Infektionen verursacht durch einen Stamm von Klebsiella pneumoniae , der die plasmidische Betalaktamase SHV-5 produziert. Innerhalb eines Beobachtungszeitraumes von einem Jahr und neun Monaten verursachte dieser Stamm bei 22 Patienten schwere nosokomiale Infektionen zumeist der tiefen Atemwege. Der Erreger war resistent gegenüber Penicillinen, Cephalosporinen der dritten Generation, Aztreonam, Chloramphenicol, Tetrazyklin und Co-trimoxazol. Die Resistenzdeterminanten waren auf Escherichia coli übertragbar. Alle Isolate produzierten eine Betalaktamase mit einem isoelektrischen Punkt von 8,2, die Ceftazidim hydrolysierte. Diese Merkmale zusammen mit dem Resistenz-Phänotyp sind identisch mit denen eines mitgeführten Referenzstammes, der die Betalaktamase SHV-5 produziert. Alle K. pneumoniae -Stämme waren identisch in ihrem Kapsel-Serotyp, ihrem Plasmidmuster und ihrem Plasmid-Fingerprint (nach Verdauen mit der Restriktionsendonuclease Dra I). Wir schließen daraus, daß dieser Ausbruch von Infektionen durch einen einzigen Klon eines Betalaktamase-produzierenden K. pneumoniae -Stammes verursacht wurde, der sich über verschiedene Stationen verbreitete. Diese Ergebnisse signalisieren das Risiko von Therapiemißerfolgen in Deutschland bei empirischem Einsatz von Drittgenerations-Cephalosporinen bei Infektionen mit K. pneumoniae . The first outbreak of infections caused by an SHV-5 producing strain of Klebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistant K. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable to Escherichia coli . All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. The K. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone of K. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

S. Schweighart - One of the best experts on this subject based on the ideXlab platform.

  • Spread of Klebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients.
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, Rosenthal E, E. Eberlein, M. Holley, S. Schweighart
    Abstract:

    The first outbreak of infections caused by an SHV-5 producing strain ofKlebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistantK. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable toEscherichia coli. All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. TheK. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone ofK. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

  • Spread ofklebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, E. Eberlein, M. Holley, S. Schweighart, E. Rosenthal
    Abstract:

    Wir berichten über das in Deutschland erstmalig gehäufte Auftreten von Infektionen verursacht durch einen Stamm von Klebsiella pneumoniae , der die plasmidische Betalaktamase SHV-5 produziert. Innerhalb eines Beobachtungszeitraumes von einem Jahr und neun Monaten verursachte dieser Stamm bei 22 Patienten schwere nosokomiale Infektionen zumeist der tiefen Atemwege. Der Erreger war resistent gegenüber Penicillinen, Cephalosporinen der dritten Generation, Aztreonam, Chloramphenicol, Tetrazyklin und Co-trimoxazol. Die Resistenzdeterminanten waren auf Escherichia coli übertragbar. Alle Isolate produzierten eine Betalaktamase mit einem isoelektrischen Punkt von 8,2, die Ceftazidim hydrolysierte. Diese Merkmale zusammen mit dem Resistenz-Phänotyp sind identisch mit denen eines mitgeführten Referenzstammes, der die Betalaktamase SHV-5 produziert. Alle K. pneumoniae -Stämme waren identisch in ihrem Kapsel-Serotyp, ihrem Plasmidmuster und ihrem Plasmid-Fingerprint (nach Verdauen mit der Restriktionsendonuclease Dra I). Wir schließen daraus, daß dieser Ausbruch von Infektionen durch einen einzigen Klon eines Betalaktamase-produzierenden K. pneumoniae -Stammes verursacht wurde, der sich über verschiedene Stationen verbreitete. Diese Ergebnisse signalisieren das Risiko von Therapiemißerfolgen in Deutschland bei empirischem Einsatz von Drittgenerations-Cephalosporinen bei Infektionen mit K. pneumoniae . The first outbreak of infections caused by an SHV-5 producing strain of Klebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistant K. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable to Escherichia coli . All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. The K. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone of K. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

E. Eberlein - One of the best experts on this subject based on the ideXlab platform.

  • Spread of Klebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients.
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, Rosenthal E, E. Eberlein, M. Holley, S. Schweighart
    Abstract:

    The first outbreak of infections caused by an SHV-5 producing strain ofKlebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistantK. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable toEscherichia coli. All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. TheK. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone ofK. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

  • Spread ofklebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, E. Eberlein, M. Holley, S. Schweighart, E. Rosenthal
    Abstract:

    Wir berichten über das in Deutschland erstmalig gehäufte Auftreten von Infektionen verursacht durch einen Stamm von Klebsiella pneumoniae , der die plasmidische Betalaktamase SHV-5 produziert. Innerhalb eines Beobachtungszeitraumes von einem Jahr und neun Monaten verursachte dieser Stamm bei 22 Patienten schwere nosokomiale Infektionen zumeist der tiefen Atemwege. Der Erreger war resistent gegenüber Penicillinen, Cephalosporinen der dritten Generation, Aztreonam, Chloramphenicol, Tetrazyklin und Co-trimoxazol. Die Resistenzdeterminanten waren auf Escherichia coli übertragbar. Alle Isolate produzierten eine Betalaktamase mit einem isoelektrischen Punkt von 8,2, die Ceftazidim hydrolysierte. Diese Merkmale zusammen mit dem Resistenz-Phänotyp sind identisch mit denen eines mitgeführten Referenzstammes, der die Betalaktamase SHV-5 produziert. Alle K. pneumoniae -Stämme waren identisch in ihrem Kapsel-Serotyp, ihrem Plasmidmuster und ihrem Plasmid-Fingerprint (nach Verdauen mit der Restriktionsendonuclease Dra I). Wir schließen daraus, daß dieser Ausbruch von Infektionen durch einen einzigen Klon eines Betalaktamase-produzierenden K. pneumoniae -Stammes verursacht wurde, der sich über verschiedene Stationen verbreitete. Diese Ergebnisse signalisieren das Risiko von Therapiemißerfolgen in Deutschland bei empirischem Einsatz von Drittgenerations-Cephalosporinen bei Infektionen mit K. pneumoniae . The first outbreak of infections caused by an SHV-5 producing strain of Klebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistant K. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable to Escherichia coli . All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. The K. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone of K. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

M. Holley - One of the best experts on this subject based on the ideXlab platform.

  • Spread of Klebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients.
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, Rosenthal E, E. Eberlein, M. Holley, S. Schweighart
    Abstract:

    The first outbreak of infections caused by an SHV-5 producing strain ofKlebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistantK. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable toEscherichia coli. All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. TheK. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone ofK. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.

  • Spread ofklebsiella pneumoniae producing SHV-5 Beta-Lactamase among hospitalized patients
    Infection, 1993
    Co-Authors: Adolf Bauernfeind, E. Eberlein, M. Holley, S. Schweighart, E. Rosenthal
    Abstract:

    Wir berichten über das in Deutschland erstmalig gehäufte Auftreten von Infektionen verursacht durch einen Stamm von Klebsiella pneumoniae , der die plasmidische Betalaktamase SHV-5 produziert. Innerhalb eines Beobachtungszeitraumes von einem Jahr und neun Monaten verursachte dieser Stamm bei 22 Patienten schwere nosokomiale Infektionen zumeist der tiefen Atemwege. Der Erreger war resistent gegenüber Penicillinen, Cephalosporinen der dritten Generation, Aztreonam, Chloramphenicol, Tetrazyklin und Co-trimoxazol. Die Resistenzdeterminanten waren auf Escherichia coli übertragbar. Alle Isolate produzierten eine Betalaktamase mit einem isoelektrischen Punkt von 8,2, die Ceftazidim hydrolysierte. Diese Merkmale zusammen mit dem Resistenz-Phänotyp sind identisch mit denen eines mitgeführten Referenzstammes, der die Betalaktamase SHV-5 produziert. Alle K. pneumoniae -Stämme waren identisch in ihrem Kapsel-Serotyp, ihrem Plasmidmuster und ihrem Plasmid-Fingerprint (nach Verdauen mit der Restriktionsendonuclease Dra I). Wir schließen daraus, daß dieser Ausbruch von Infektionen durch einen einzigen Klon eines Betalaktamase-produzierenden K. pneumoniae -Stammes verursacht wurde, der sich über verschiedene Stationen verbreitete. Diese Ergebnisse signalisieren das Risiko von Therapiemißerfolgen in Deutschland bei empirischem Einsatz von Drittgenerations-Cephalosporinen bei Infektionen mit K. pneumoniae . The first outbreak of infections caused by an SHV-5 producing strain of Klebsiella pneumoniae is reported. Within a period of 1 year and 9 months, multiresistant K. pneumoniae strains caused severe infections, mostly of the lower respiratory tract, in 22 patients. The strains were resistant to penicillins, third-generation cephalosporins, aztreonam, chloramphenicol, tetracycline and co-trimoxazole. The resistance determinants were transferable to Escherichia coli . All isolates produced a Beta-Lactamase with a pI of 8.2. Ceftazidime was hydrolyzed at this band. These characteristics, together with the resistance phenotype, are identical to those of a reference strain producing the Beta-Lactamase SHV-5. The K. pneumoniae strains of all patients were identical in their capsular serotype (K1), plasmid pattern and plasmid fingerprint after digestion with Dra I restriction endonuclease. We conclude that this outbreak was caused by the spread of one clone of K. pneumoniae producing SHV-5 Beta-Lactamase among patients of different wards. Our results indicate a real risk for failure of therapy by third-generation cephalosporins in intensive care patients due to SHV-5 producing pathogens.