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I Iob - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Beta endorphin Beta Lipotropin immunoreactivity content in the csf of patients affected by deafferentation pain syndromes
Pharmacological Research, 1991Co-Authors: Stefano Govoni, G Salar, L Alessio, F Battaini, I IobAbstract:Beta-endorphin/Beta-Lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain problems. No statistically significant variation in BE/BLPH-IR levels were found between controls and subjects with different types of chronic pain.
Gunnar Knutsen - One of the best experts on this subject based on the ideXlab platform.
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elevated plasma Beta endorphin Beta Lipotropin concentration following a radius fracture
Scandinavian Journal of Clinical & Laboratory Investigation, 2004Co-Authors: Oddmund Johansen, J Winge, O Reikeras, T Jensen, Gunnar KnutsenAbstract:Plasma Beta-endorphin/Beta-Lipotropin concentration was assessed soon after a fracture. Blood samples from 14 patients with radius fractures were obtained from both arms soon after admission to the hospital (mean 245 min) after the accident. Follow-up samples were taken after healing of the fractures. Higher plasma Beta-endorphin/Beta-Lipotropin concentrations were found in blood samples taken soon after a fracture in both arms compared with the concentrations after healing of the fracture. At admission, mean Beta-endorphin/Beta-Lipotropin concentrations in the fractured and the contralateral arms were 12.7 pmol/L and 13.2 pmol/L, and after recovery 11.1 pmol/L and 11.5 pmol/L (p=0.012 and p=0.041), respectively. The pain decreased according to the visual analogue scale (VAS) (0-10) from 4.64 at admission to 0.58 after healing (p<0.001). In conclusion, this study showed that Beta-endorphin/Beta-Lipotropin concentrations are increased in both arms following a radius fracture compared to the level after ...
G Salar - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Beta endorphin Beta Lipotropin immunoreactivity content in the csf of patients affected by deafferentation pain syndromes
Pharmacological Research, 1991Co-Authors: Stefano Govoni, G Salar, L Alessio, F Battaini, I IobAbstract:Beta-endorphin/Beta-Lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain problems. No statistically significant variation in BE/BLPH-IR levels were found between controls and subjects with different types of chronic pain.
Huda Akil - One of the best experts on this subject based on the ideXlab platform.
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altered ratios of Beta endorphin Beta Lipotropin released from anterior lobe corticotropes with increased secretory drive ii repeated stress
Journal of Neuroendocrinology, 1993Co-Authors: Elizabeth A Young, Stanley J. Watson, R Day, Martin K H Schafer, Huda AkilAbstract:A number of stimuli including acute footshock and electrically-induced seizures lead to release of Beta-endorphin immunoreactivity from the anterior pituitary corticotropes. Gel filtration of this Beta-endorphin immunoreactivity indicates that approximately 3-fold more Beta-endorphin than Beta-Lipotropin is released into plasma following these acute stressors. A similar preponderance of Beta-endorphin over Beta-Lipotropin is seen in the media of short-term anterior lobe cell suspensions stimulated with ovine corticotropin-releasing hormone. Previous studies indicated that footshock stress, when administered repeatedly, can increase the biosynthesis of anterior lobe proopiomelanocortin (POMC) as indicated by increased steady state adrenocorticotropin/Beta-endorphin content as well as increased POMC mRNA levels and increased POMC biosynthesis and rate of processing as measured by pulse-labeling and pulse-chase studies. The goal of the present studies was to determine whether this increased biosynthetic drive results in an alteration in the end products secreted with repeated stress. Acute footshock in a rat which has received 14 days of chronic footshock releases proportionately more Beta-Lipotropin than is released in a naive rat. Chronic electrically-induced seizures, which also increase anterior lobe POMC derived peptide stores, lead to a similar shift in the ratio of Beta-Lipotropin:Beta-endorphin released following stress. These data suggest that chronic drive and the subsequent changes in POMC peptide stores may lead to a decrease in the proportion of Beta-endorphin size immunoreactivity in the releasable pool of the anterior lobe corticotrope, thus altering the hormonal signal from the anterior lobe corticotrope.
Stefano Govoni - One of the best experts on this subject based on the ideXlab platform.
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evaluation of Beta endorphin Beta Lipotropin immunoreactivity content in the csf of patients affected by deafferentation pain syndromes
Pharmacological Research, 1991Co-Authors: Stefano Govoni, G Salar, L Alessio, F Battaini, I IobAbstract:Beta-endorphin/Beta-Lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain problems. No statistically significant variation in BE/BLPH-IR levels were found between controls and subjects with different types of chronic pain.