The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform
Toshio Honda - One of the best experts on this subject based on the ideXlab platform.
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efficient formal synthesis of axamide 1 and axisonitrile 1 via an intramolecular hosomi sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
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Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
Kazunori Takahashi - One of the best experts on this subject based on the ideXlab platform.
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efficient formal synthesis of axamide 1 and axisonitrile 1 via an intramolecular hosomi sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
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Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
Kentaro Takeda - One of the best experts on this subject based on the ideXlab platform.
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efficient formal synthesis of axamide 1 and axisonitrile 1 via an intramolecular hosomi sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
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Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction
Tetrahedron Letters, 2010Co-Authors: Kazunori Takahashi, Kentaro Takeda, Toshio HondaAbstract:Abstract A formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 was achieved by using an intramolecular Hosomi–Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a Bicyclic Compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step.
Kousei Shimada - One of the best experts on this subject based on the ideXlab platform.
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discovery of a novel Bicyclic Compound ds54360155 as an orally potent analgesic without mu opioid receptor agonist activity
Bioorganic & Medicinal Chemistry Letters, 2019Co-Authors: Tsuyoshi Arita, Masayoshi Asano, Kazufumi Kubota, Yuki Domon, Nobuo Machinaga, Kousei ShimadaAbstract:Abstract We synthesized derivatives of a natural alkaloid, conolidine, and evaluated these derivatives in the acetic acid-induced writhing test and formalin test in ddY mice after oral administration. As a result, we identified (5S)-6-methyl-1,3,4,5,6,8-hexahydro-7H-2,5-methano[1,5]diazonino[7,8-b]indol-7-one sulfate salt, 15a (DS54360155), with a unique and original Bicyclic skeleton, as an analgesic more potent than conolidine. Moreover, 15a did not exhibit mu-opioid receptor agonist activity.
Seiji Shinkai - One of the best experts on this subject based on the ideXlab platform.
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allosteric function facilitates template assisted olefin metathesis
Chemical Communications, 2005Co-Authors: Rie Wakabayashi, Yohei Kubo, Osamu Hirata, Masayuki Takeuchi, Seiji ShinkaiAbstract:Template assisted olefin metathesis of an allosteric host 1b to give the corresponding Bicyclic Compound 1c was achieved and 1c can allosterically bind the template guest diamines, 2 and 3 with different affinity and cooperativity.