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Binder Property

The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform

Cheng Chaw – 1st expert on this subject based on the ideXlab platform

  • Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.

  • mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.

Grace Loong Ting – 2nd expert on this subject based on the ideXlab platform

  • Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.

  • mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.

Yen Yee Chan – 3rd expert on this subject based on the ideXlab platform

  • Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.

  • mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
    Journal of Applied Polymer Science, 2019
    Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng Chaw

    Abstract:

    ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a
    mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol
    as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to
    modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution
    and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at
    isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good
    flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was
    because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s
    hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated
    matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had
    modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.