The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Cheng Chaw - One of the best experts on this subject based on the ideXlab platform.
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Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
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mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
Grace Loong Ting - One of the best experts on this subject based on the ideXlab platform.
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Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
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mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
Yen Yee Chan - One of the best experts on this subject based on the ideXlab platform.
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Mixed solvent system as Binder for the production of silicified microcrystalline cellulose‐based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
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mixed solvent system as Binder for the production of silicified microcrystalline cellulose based pellets
Journal of Applied Polymer Science, 2019Co-Authors: Grace Loong Ting, Yen Yee Chan, Cheng ChawAbstract:ABSTRACT: Silicified microcrystalline cellulose pellets with hydroxypropyl methylcellullose (HPMC) as modifier were prepared using a mixed solvent as liquid Binder. Pellets were produced using extrusion-spheronization with a mixed solvent consisting of water and isopropanol as liquid Binder. The key spheronization aid was Prosolv® SMCC 90. Low viscosity grade HPMC was incorporated aiming to modify release of indometacin. Physical characteristics including breaking load, apparent density and flow properties, particle size distribution and shape were determined. Drug loaded pellets were also tested for dissolution profiles. By adjusting liquid Binder Property, at isopropanol to water ratio of 3.5 to 6.5, pellets of desirable size and shape with reasonable yields were obtained. Pellets exhibited good flow Property and they were mechanically strong. Pellet with higher HPMC content displayed a faster drug dissolution profile. This was because low viscosity grade HPMC was not enough to create strong gel. Instead hydration of HPMC molecules increased matrix’s hydrophilicity and weakened the structure of pellet faster. The release of indometacin was partly based on the erosion of hydrated matrix. The presence of HPMC in the pellets would require a mixed solvent to produce desirable shape. Incorporation of HPMC had modified drug release from the pellets without further coating. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47924.
Hua Li - One of the best experts on this subject based on the ideXlab platform.
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influence of Binder Property and mortar thickness on high temperature performance of cold recycled mixtures with asphalt emulsion
Materials, 2019Co-Authors: Zhanqi Wang, Junqiu Zheng, Hua LiAbstract:Four kinds of cold recycling (CR) mixtures with different asphalt emulsions were studied for their high-temperature performance in both Binder properties and internal structures aspects. Digital image processing was introduced to determine the thickness spectrum for the asphalt mortar of the CR mixtures from a mesoscopic perspective. The time–temperature sweep (TTS) test was conducted to obtain the rheological parameters of each corresponding emulsified residue and the permanent deformation performance of each CR mixture was measured by dynamic creep test. A principle component analysis (PCA) was used to compare the typical performance parameters of the CR mixtures and find the factors controlling the rutting resistance of CR mixtures. The results show that the high-temperature performance of the CR mixtures with a modified emulsified asphalt showed improvements relative to the nominal case. Including Marshall stability, several parameters from the rheological properties of Binder (G*/sinδ, flow number) and mortar thickness (max, range proportion 0–10 mm) could significantly influence the high-temperature performance and rutting resistance of the CR mixtures.
Ohsun Kwon - One of the best experts on this subject based on the ideXlab platform.
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Reliable Estimation of Binder Properties Using the Large Molecular Size (%) from Asphalt Mixtures
New Frontiers in Road and Airport Engineering, 2015Co-Authors: Ohsun KwonAbstract:In general, the Binder properties of asphalt mixture can be measured only when the Binder is recovered from the mixture. However, this study showed the method of estimating the Binder Property reliably using gel-permeation chromatograph (GPC) technique without Binder recovery from loose mixes, compacted specimens or field cores. The large molecular size (LMS) of asphalt can be measured by the GPC test directly from the asphalt mixture sample and then used to estimate necessary Property of the Binder. To show its applicability, this study estimated the service life plus four properties [the stiffness (G*/sinδ), absolute viscosity (AVS), penetration (PEN), and dynamic shear rheometer (DSR) pass/fail (P/F) temperature] based on the LMS. Many cores taken from 6 sites in Korean Expressways and a lab-prepared mixture were used. The regression analyses found that the AVS and P/F temperature showed very high correlations (R2 > 0.98) with LMS. The G*/sinδ, PEN, and service life had high correlations with LMS showing R2≒0.93, 0.92, and 0.88, respectively. Therefore, LMS is a good prediction tool for Binder’s physical properties. Therefore, it is possible to say that the LMS will be a reliable prediction medium of physical properties of asphalt Binder in the mix.
