The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform

Yi Deng - One of the best experts on this subject based on the ideXlab platform.

  • graphene oxide decorated microporous polyetheretherketone with superior antibacterial capability and in vitro osteogenesis for orthopedic Implant
    Macromolecular Bioscience, 2018
    Co-Authors: Ling Ouyang, Yi Deng, Lei Yang, Weizhong Yang, Zhigang Chen, Taosheng Dong
    Abstract:

    Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π-π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO-SPEEK exhibits excellent suppression toward Escherichia coli. In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real-time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO-SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast-like MG-63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO-SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO-SPEEK has a great potential as the Bioactive Implant material in bone tissue engineering.

  • preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

  • Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
    Colloids and surfaces. B Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

Shicheng Wei - One of the best experts on this subject based on the ideXlab platform.

  • preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

  • Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
    Colloids and surfaces. B Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

Ping Zhou - One of the best experts on this subject based on the ideXlab platform.

  • preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

  • Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
    Colloids and surfaces. B Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

Jie Wei - One of the best experts on this subject based on the ideXlab platform.

  • preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

  • Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
    Colloids and surfaces. B Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

Zhihui Tang - One of the best experts on this subject based on the ideXlab platform.

  • preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
    Colloids and Surfaces B: Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.

  • Preparation, characterization, cellular response and in vivo osseointegration of polyetheretherketone/nano-hydroxyapatite/carbon fiber ternary biocomposite.
    Colloids and surfaces. B Biointerfaces, 2015
    Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng Wei
    Abstract:

    As FDA-approved Implantable material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic Implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/orthopedic material. The present work aimed at developing a PEEK Bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite Implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as Bioactive Implant material in dental and orthopedic applications.